| Cat.No.: | EAb-1342 |
| Product Name: | ISG15 Polyclonal Antibody, FITC Conjugated |
| Antibody Type: | Polyclonal |
| Conjugate: | FITC |
| Host: | Rabbit |
| Isotype: | IgG |
| Purification: | Protein G Purified |
| Appearance: | Liquid |
| Formulation: | 0.03% Proclin 300, 50% Glycerol, 0.01M PBS, PH 7.4. |
| Applications: | ELISA |
| Species Reactivity: | Human |
| Storage: | -20°C |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Alternative Name: | G1P2, UCRP, ISG15, Interferon-induced 15 kDa protein Interferon-induced 17 kDa protein IP17 Ubiquitin cross-reactive protein hUCRP |
| Scientific Background: | Ubiquitin-like protein that is conjugated to intracellular target proteins after IFN-alpha or IFN-beta stimulation. Its enzymatic pathway is partially distinct from that of ubiquitin, differing in substrate specificity and interaction with ligating enzymes. ISG15 conjugation pathway uses a dedicated E1 enzyme, but seems to converge with the Ub conjugation pathway at the level of a specific E2 enzyme. Targets include STAT1, SERPINA3G/SPI2A, JAK1, MAPK3/ERK1, PLCG1, EIF2AK2/PKR, MX1/MxA, and RIG-1. Deconjugated by USP18/UBP43. Shows specific chemotactic activity towards neutrophils and activates them to induce release of eosinophil chemotactic factors. May serve as a trans-acting binding factor directing the association of ligated target proteins to intermediate filaments. May also be involved in autocrine, paracrine and endocrine mechanisms, as in cell-to-cell signaling, possibly partly by inducing IFN-gamma secretion by monocytes and macrophages. Seems to display antiviral activity during viral infections. Ref. 12 Ref. 13 Ref. 14 Ref. 15 Ref. 20 Ref. 21In response to IFN-tau secreted by the conceptus, may ligate to and regulate proteins involved in the release of prostaglandin F2-alpha (PGF), and thus prevent lysis of the corpus luteum and maintain the pregnancy |
| Product Types | ||
| ◆ Antibodies | ||
| EAb-1161 | ISG15 Polyclonal Antibody, HRP Conjugated | Inquiry |
| EAb-1342 | ISG15 Polyclonal Antibody, FITC Conjugated | Inquiry |
| EAb-1344 | ISG15 Polyclonal Antibody, Biotin Conjugated | Inquiry |
| EAb-1345 | ISG15 Polyclonal Antibody | Inquiry |
| Related Gene / Proteins | |||
| ISG15 | |||
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