USP5 Polyclonal Antibody, HRP Conjugated

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Cat.No.:  EAb-1483
Product Name:  USP5 Polyclonal Antibody, HRP Conjugated
Antibody Type:  Polyclonal
Conjugate:  HRP
Host:  Rabbit
Isotype:  IgG
Purification:  Protein G Purified
Appearance:  Liquid
Formulation:  0.03% Proclin 300, 50% Glycerol, 0.01M PBS, PH 7.4.
Applications:  ELISA
Species Reactivity:  Human
Storage:  -20°C
Warning:  For Research Use Only! Not For Use in Humans.
Alternative Name:  Ubiquitin carboxyl-terminal hydrolase 5, Deubiquitinating enzyme 5, Isopeptidase T, Ubiquitin thioesterase 5, Ubiquitin-specific-processing protease 5, USP5, ISOT
Scientific Background:  Cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. Involved in unanchored 'Lys-48'-linked polyubiquitin disassembly. Binds linear and 'Lys-63'-linked polyubiquitin with a lower affinity. Knock-down of USP5 causes the accumulation of p53/TP53 and an increase in p53/TP53 transcriptional activity because the unanchored polyubiquitin that accumulates is able to compete with ubiquitinated p53/TP53 but not with MDM2 for proteasomal recognition.

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For Research Use Only. Not for use in diagnostic or therapeutic procedures.
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