| Cat.No.: | EAb-1533 |
| Product Name: | Ubiquitin-Conjugating Enzyme E2 K Polyclonal Antibody, FITC Conjugated |
| Antibody Type: | Polyclonal |
| Conjugate: | FITC |
| Host: | Rabbit |
| Isotype: | IgG |
| Purification: | Protein G Purified |
| Appearance: | Liquid |
| Formulation: | 0.03% Proclin 300, 50% Glycerol, 0.01M PBS, PH 7.4. |
| Applications: | ELISA |
| Species Reactivity: | Human |
| Storage: | -20°C |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Alternative Name: | UBE2K, HIP2, LIG |
| Scientific Background: | Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro, in the presence or in the absence of BRCA1-BARD1 E3 ubiquitin-protein ligase complex, catalyzes the synthesis of 'Lys-48'-linked polyubiquitin chains. Does not transfer ubiquitin directly to but elongates monoubiquitinated substrate protein. Mediates the selective degradation of short-lived and abnormal proteins, such as the endoplasmic reticulum-associated degradation (ERAD) of misfolded lumenal proteins. Ubiquitinates huntingtin. May mediate foam cell formation by the suppression of apoptosis of lipid-bearing macrophages through ubiquitination and subsequence degradation of p53/TP53. Proposed to be involved in ubiquitination and proteolytic processing of NF-kappa-B; in vitro supports ubiquitination of NFKB1. In case of infection by cytomegaloviruses may be involved in the US11-dependent degradation of MHC class I heavy chains following their export from the ER to the cytosol. In case of viral infections may be involved in the HPV E7 protein-dependent degradation of RB1. |
| Product Types | ||
| ◆ Cell Lines | ||
| CL-0029 | Human E2F1 Knockout Cell Line 163bp insertion | Inquiry |
| ◆ Research Kits | ||
| EKIT-0042 | E2F4 Gene Knockdown Quantification Kit | Inquiry |
| ◆ Antibodies | ||
| EAb-1533 | Ubiquitin-Conjugating Enzyme E2 K Polyclonal Antibody, FITC Conjugated | Inquiry |
| EAb-1535 | Ubiquitin-Conjugating Enzyme E2 K Polyclonal Antibody, HRP Conjugated | Inquiry |
| EAb-1540 | Ubiquitin-Conjugating Enzyme E2 K Polyclonal Antibody, Biotin Conjugated | Inquiry |
| Related Gene / Proteins | |||
| E2 K | E2F1 | E2F4 | |
USA
Enter your email here to subscribe.
Follow us on
Easy access to products and services you need from our library via powerful searching tools
