| Cat.No.: | EAb-1855 |
| Product Name: | POLR2B Polyclonal Antibody |
| Antibody Type: | Polyclonal |
| Immunogen: | This antibody was raised against a peptide within the N-terminal region of human POLR2B. |
| Host: | Rabbit |
| Isotype: | IgG |
| Molecular Weight: | 135 kDa |
| Purification: | Affinity Purified |
| Appearance: | Liquid |
| Formulation: | Purified IgG in PBS with 30% glycerol and 0.035% sodium azide. |
| Applications: | IP: 5 - 10 µl per IP; WB: 1:500 - 1:1,000 dilution^Recommended dilutions/conditions may not be available for all applications. Specific conditions for reactivity should be optimized by the end user. |
| Species Reactivity: | Human |
| Storage: | -20°C |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Scientific Background: | POLR2B (polymerase (RNA) II (DNA directed) polypeptide B, 140 kDa) DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB2 is part of the core element with the central large cleft, the clamp element that moves to open and close the cleft and the jaws that are thought to grab the incoming DNA template. |
| Product Types | ||
| ◆ Bioactive Small Molecules | ||
| BSM-0194 | PFI-3 | Inquiry |
| ◆ Antibodies | ||
| EAb-0231 | Polycomb 2 Polyclonal Antibody | Inquiry |
| EAb-0232 | Polycomb 2 Polyclonal Antibody | Inquiry |
| ◆ Cell Lines | ||
| CL-0399 | Human POLB Knockout Cell Line 1bp deletion | Inquiry |
| CL-0407 | Human POLE Knockout Cell Line 2bp deletion | Inquiry |
| Related Gene / Proteins | |||
| POLB | POLE | POLE3 | POLE4 |
| POLG2 | POLH | POLI | POLK |
| POLL | POLM | POLN | POLQ |
| POLR2B | Polybromo 1 | Polycomb 2 | POMP |
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