| Cat.No.: | EAb-1986 |
| Product Name: | FTO Polyclonal Antibody |
| Antibody Type: | Polyclonal |
| Immunogen: | This antibody was raised against a peptide within the N-terminal region of human FTO. |
| Host: | Rabbit |
| Isotype: | IgG |
| Molecular Weight: | 60 kDa |
| Purification: | Affinity Purified |
| Appearance: | Liquid |
| Formulation: | Purified IgG in PBS with 30% glycerol and 0.035% sodium azide. |
| Applications: | WB: 1:500 - 1:2,000 dilution^Recommended dilutions/conditions may not be available for all applications. Specific conditions for reactivity should be optimized by the end user. |
| Species Reactivity: | Human |
| Storage: | -20°C |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Scientific Background: | FTO (fat mass and obesity associated) is a dioxygenase that repairs alkylated DNA and RNA by oxidative demethylation. This protein has high activity towards single-stranded RNA containing 3-methyluracil and single-stranded DNA containing 3-methylthymine. FTO has low demethylase activity towards single-stranded DNA containing 1-methyladenine or 3-methylcytosine and has no activity towards 1-methylguanine or double-stranded DNA. FTO contributes to the regulation of the global metabolic rate, energy expenditure, energy homeostasis, regulation of body size and body fat accumulation. FTO has recently been shown to have the highest activity towards demethylation of 6-methyladeninine in single-stranded RNA suggesting that FTO is involved in processing of nuclear RNAs and may play an important role in RNA epigenetics. |
| Product Types | ||
| ◆ Research Kits | ||
| EKIT-0554 | FTO Chemiluminescent Assay Kit | Inquiry |
| ◆ Proteins & Enzymes | ||
| PE-1797 | FTO, His-Tag (Sf9 derived) | Inquiry |
| PE-1800 | FTO , His-Tag (E. coli derived) | Inquiry |
| PE-2380 | Recombinant Human FTSJ3 protein | Inquiry |
| ◆ Antibodies | ||
| EAb-1986 | FTO Polyclonal Antibody | Inquiry |
| Related Gene / Proteins | |||
| FTO | FTSJ2 | FTSJ3 | FTSJD2 |
USA
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