| Cat.No.: | EAb-2147 |
| Product Name: | AATF / Che-1 Monoclonal Antibody |
| Antibody Type: | Monoclonal |
| Immunogen: | This antibody was raised against peptide comprising amino acids 1-39 of mouse AATF (Apoptosis-antagonizing transcription factor) (NP_062790). |
| Host: | Rat |
| Isotype: | IgG2a |
| Purification: | Protein A Chromatography |
| Appearance: | Liquid |
| Formulation: | Purified IgG in PBS with 30% glycerol and 0.035% sodium azide. |
| Applications: | WB: 2 - 4 µg/mlIF: 1:100 - 1:500^Recommended dilutions/conditions may not be available for all applications. Specific conditions for reactivity should be optimized by the end user. |
| Species Reactivity: | Human, Mouse |
| Storage: | -20°C |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Scientific Background: | AATF/Che-1, or Apoptosis-antagonizing Transcription Factor is a key regulator of apoptosis through its interaction with MAP3K12 (DLK), as well as regulation of gene transcription and cell profileration through interaction with RNA polymerase II. AATF/Che-1 may promote cell proliferation by acting as a competitor of histone deacetylase 1 (HDAC1) interaction with the growth inhibiting protein pRb. AATF / Che-1 binding to pRb may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. |
| Product Types | ||
| ◆ Extracts & Lysates | ||
| EL-0138 | Recombinant Human AAAS 293 Cell Lysate | Inquiry |
| ◆ Antibodies | ||
| EAb-2147 | AATF / Che-1 Monoclonal Antibody | Inquiry |
| Related Gene / Proteins | |||
| AAAS | AATF | ||
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