| Cat.No.: | EAb-2150 |
| Product Name: | WRN Monoclonal Antibody |
| Antibody Type: | Monoclonal |
| Immunogen: | This WRN antibody was raised against a recombinant protein corresponding to amino acids 1072 - 1432 of human WRN. |
| Host: | Mouse |
| Isotype: | IgG1 |
| Molecular Weight: | 162 kDa |
| Purification: | Protein G Chromatography |
| Appearance: | Liquid |
| Formulation: | Purified IgG in PBS with 30% glycerol and 0.035% sodium azide. |
| Applications: | ICC/IF: 0.5 µg/ml dilution; WB: 0.5 - 2 µg/ml dilution; IHC (paraffin)^Recommended dilutions/conditions may not be available for all applications. Specific conditions for reactivity should be optimized by the end user. |
| Species Reactivity: | Human |
| Storage: | -20°C |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Scientific Background: | WRN protein is a RECQ helicase that contains 3′ to 5′ helicase activity and DNA-dependent ATPase activity. WRN takes part in many processes, including DNA replication, recombination, repair, and telomere maintenance. Mutations in the gene encoding WRN cause an autosomal recessive segmental progeria called Werner syndrome (WS). WS patients prematurely develop atrophic skin, thin gray hair, osteoporosis, type II diabetes, cataracts, arteriosclerosis and cancer. |
| Product Types | ||
| ◆ Cell Lines | ||
| CL-0446 | Human WRN Knockout Cell Line 17bp deletion | Inquiry |
| CL-0447 | Human WRNIP1 Knockout Cell Line | Inquiry |
| ◆ Antibodies | ||
| EAb-2150 | WRN Monoclonal Antibody | Inquiry |
| ◆ Proteins & Enzymes | ||
| PE-3061 | WRAD2 | Inquiry |
| Related Gene / Proteins | |||
| WRAD2 | WRN | WRNIP1 | |
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