HDAC3 Monoclonal Antibody (Y415) - Azide and BSA free

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Cat.No.:  EAb-2494
Product Name:  HDAC3 Monoclonal Antibody (Y415) - Azide and BSA free
Product Overview:  Rabbit monoclonal (Y415) to detect HDAC3 - Azide and BSA free
Antibody Type:  Monoclonal
Clone Designation:  Y415
Immunogen:  Synthetic peptide corresponding to Human HDAC3 (C terminal).
Host:  Rabbit
Isotype:  IgG
Purification:  Protein A purified
Appearance:  Liquid
Formulation:  pH: 7.20, 59% PBS
Applications:  WB, IHC-P, ICC/IF, IP, Flow Cyt
Species Reactivity:  Mouse, Rat, Human
Storage:  -20°C.
Warning:  For Research Use Only! Not For Use in Humans.
Alternative Name:  HD3 antibody/HDAC 3 antibody/HDAC3 antibody
Scientific Background:  Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Probably participates in the regulation of transcription through its binding to the zinc-finger transcription factor YY1; increases YY1 repression activity. Required to repress transcription of the POU1F1 transcription factor. Acts as a molecular chaperone for shuttling phosphorylated NR2C1 to PML bodies for sumoylation.

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For Research Use Only. Not for use in diagnostic or therapeutic procedures.
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