| Cat.No.: | EAb-2634 |
| Product Name: | HDAC3 Monoclonal Antibody (3G6) (C-terminal) (HRP) |
| Product Overview: | Mouse monoclonal (3G6) to detect HDAC3 - C-terminal (HRP) |
| Antibody Type: | Monoclonal |
| Clone Designation: | 3G6 |
| Immunogen: | Recombinant fragment corresponding to Human HDAC3 aa 411-428 (C terminal). |
| Immunogen Sequence: | NEFYDGDHDNDKESDVE |
| Host: | Mouse |
| Isotype: | IgG2a |
| Purification: | Protein G purified |
| Appearance: | Liquid |
| Formulation: | 0.01% Thimerosal (merthiolate), 99% PBS |
| Applications: | IP, WB |
| Species Reactivity: | Mouse, Human |
| Storage: | +4°C. |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Accession: | O15379 |
| Alternative Name: | HD3 antibody/HDAC 3 antibody/HDAC3 antibody |
| Scientific Background: | Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Probably participates in the regulation of transcription through its binding to the zinc-finger transcription factor YY1; increases YY1 repression activity. Required to repress transcription of the POU1F1 transcription factor. Acts as a molecular chaperone for shuttling phosphorylated NR2C1 to PML bodies for sumoylation. |
| Product Types | ||
| ◆ Extracts & Lysates | ||
| EL-0006 | Recombinant Human HDAC1 293 Cell Lysate | Inquiry |
| EL-0007 | Recombinant Human HDAC2 293 Cell Lysate | Inquiry |
| EL-0008 | Recombinant Human HDAC3 Cell Lysate | Inquiry |
| EL-0009 | Recombinant Human HDAC4 Cell Lysate | Inquiry |
| ◆ Bioactive Small Molecules | ||
| BSM-0007 | Tubacin | Inquiry |
| Related Gene / Proteins | |||
| HDAC | HDAC1 | HDAC10 | HDAC11 |
| HDAC2 | HDAC3 | hdac4 | hdac5 |
| HDAC6 | hdac7 | HDAC8 | hdac9 |
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