| Cat.No.: | EAb-2820 |
| Product Name: | KDM3A/JHDM2A Polyclonal Antibody |
| Product Overview: | Rabbit polyclonal to detect KDM3A/JHDM2A |
| Antibody Type: | Polyclonal |
| Immunogen: | Recombinant fragment within Human KDM3A/ JHDM2A (internal sequence). |
| Host: | Rabbit |
| Isotype: | IgG |
| Purification: | Immunogen affinity purified |
| Appearance: | Liquid |
| Formulation: | pH: 7.00; 0.025% Proclin, PBS, 20% Glycerol |
| Applications: | WB, IP |
| Species Reactivity: | Human |
| Storage: | -20°C. |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Accession: | Q9Y4C1 |
| Alternative Name: | DKFZp686A24246 antibody/DKFZp686P07111 antibody/JHDM2A antibody |
| Scientific Background: | Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Preferentially demethylates mono- and dimethylated H3 'Lys-9' residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 'Lys-9'. Demethylation of Lys residue generates formaldehyde and succinate. Involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes, resulting in H3 'Lys-9' demethylation and transcriptional activation. Involved in spermatogenesis by regulating expression of target genes such as PRM1 and TMP1 which are required for packaging and condensation of sperm chromatin. Involved in obesity resistance through regulation of metabolic genes such as PPARA and UCP1. |
| Product Types | ||
| ◆ Cell Lines | ||
| CL-0015 | Human KDM5B Knockout Cell Line 14bp deletion | Inquiry |
| CL-0087 | Human KDM1A Knockout Cell Line 10bp deletion | Inquiry |
| CL-0088 | Human KDM1B Knockout Cell Line 13bp deletion | Inquiry |
| CL-0089 | Human KDM2B Knockout Cell Line 14bp deletion | Inquiry |
| ◆ Antibodies | ||
| EAb-0071 | KDM1B Polyclonal Antibody | Inquiry |
| Related Gene / Proteins | |||
| JHDM1A | JHDM1B | JHDM1D | JHDM2A |
| JHDM3A | KDM1 | KDM1A | KDM1B |
| KDM2 | KDM2A | KDM2B | KDM3A |
| KDM3B | KDM4 | KDM4A | KDM4B |
| KDM4C | KDM4D | KDM4E | KDM5 More > |
| KDM5A | KDM5B | KDM5C | KDM5D |
| KDM6A | KDM6B | KDM6C | KDM7 |
| KDM7A | KDM7B | KDM8 | |
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