Cat.No.: | PE-0013 |
Product Name: | Recombinant Human HDAC1, His-tagged |
Product Overview: | Recombinant Human HDAC1 fussed with His tag was expressed in insect cells. |
Description: | Human HDAC1 (HD1) was the first protein to be linked to histone deacetylase activity. It is homologous to the yeast protein Rpd31, a relationship which has since come to define the "class I HDACs". HDAC1 promotes transcriptional repression by deacetylating lysine ε-amino groups in histone N-terminal tails, a function frequently carried out in association with multi-protein transcription repression complexes such as NuRD3, Sin34 and CoREST6. Ubiquitously expressed in human tissues HDAC1-containing complexes appear to contribute the greater part of (at least class I) deacetylase activity in HeLa nuclear extracts. Aside from its interaction with co-repressors, HDAC1 activity may be regulated by post-translation modifications such as phosphorylation9 and sumoylation or binding to the inhibitor maspin, a tumor-suppressive serpin homolog. Although originally described as a "histone deacetylase", HDAC1 has been shown to catalyze the regulatory deacetylation of non-histone proteins, including p53. Overexpression of HDAC1 has been found in various cancer types. HDAC inhibitors (HDACi) have shown considerable promise as anti-cancer agents and HDACi compounds from multiple chemical classes are in stages of drug development ranging from preclinical to phase III trials. |
Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
Molecular Weight: | 55 kDa |
Species: | Human |
Formulation: | Liquid. In 50mM TRIS, pH 8.0, 138mM sodium chloride and 10% glycerol. |
Tag: | His |
Expression System: | Insect Cells |
Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Gene Name: | HDAC1 histone deacetylase 1 [ Homo sapiens ] |
Gene ID NCBI: | 3065 |
Synonyms: | HD1; RPD3; GON-10; RPD3L1; histone deacetylase 1; reduced potassium dependency, yeast homolog-like 1 |
mRNA Refseq: | NM004964 |
Protein Refseq: | NP_004955 |
MIM: | 601241 |
Chromosome Location: | 1p34 |
Function: | NAD-dependent histone deacetylase activity (H3-K14 specific); NAD-dependent histone deacetylase activity (H4-K16 specific); NF-kappaB binding |
Product Types | ||
◆ Extracts & Lysates | ||
EL-0006 | Recombinant Human HDAC1 293 Cell Lysate | Inquiry |
EL-0007 | Recombinant Human HDAC2 293 Cell Lysate | Inquiry |
EL-0008 | Recombinant Human HDAC3 Cell Lysate | Inquiry |
EL-0009 | Recombinant Human HDAC4 Cell Lysate | Inquiry |
◆ Bioactive Small Molecules | ||
BSM-0007 | Tubacin | Inquiry |
Related Gene / Proteins | |||
HDAC | HDAC1 | HDAC10 | HDAC11 |
HDAC2 | HDAC3 | hdac4 | hdac5 |
HDAC6 | hdac7 | HDAC8 | hdac9 |
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