Cat.No.: | PE-0055 |
Product Name: | Recombinant Human Distone Deacetylase 4, GST-tagged |
Product Overview: | Recombinant human HDAC4 (612-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. |
Description: | HDAC4 or Histone Deacetylase 4 belongs to class II of the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex that represses transcription when tethered to a promoter. HDAC4 does not bind DNA directly, but through transcription factors MEF2C and MEF2D. Binding of the N terminus of HDAC4 to MEF2C represses MEF2C transcription activity. |
Applications: | HDAC Assay; Western Blot |
Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
Molecular Weight: | 77 kDa |
Purity: | >95% |
Species: | Human |
Formulation: | Recombinant protein stored in 50 mM Tris-HCl, PH 7.5, 150 mM NaCI, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol. |
Tag: | GST |
Activity: | 60 RLU/min/ng |
Expression System: | Sf9 Insect Cells |
Protein Length: | 612-end |
Concentrations: | 0.1 ug/ul |
Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Gene Name: | HDAC4 histone deacetylase 4 [ Homo sapiens ] |
Gene ID NCBI: | 9759 |
Official Symbol: | HDAC4 |
Synonyms: | HDAC4; histone deacetylase 4; HD4; AHO3; BDMR; HDACA; HA6116; HDAC-4; HDAC-A; KIAA0288; histone deacetylase 4; OTTHUMP00000164483; histone deacetylase A |
mRNA Refseq: | NM_006037 |
Protein Refseq: | NP_006028 |
MIM: | 605314 |
UniProt ID: | P56524 |
Chromosome Location: | 2q37 |
Function: | NAD-dependent histone deacetylase activity (H3-K14 specific); NAD-dependent histone deacetylase activity (H3-K9 specific); NAD-dependent histone deacetylase activity (H4-K16 specific); histone deacetylase activity; histone deacetylase activity (H3-K16 specific); hydrolase activity; transcription factor binding; histone deacetylase binding; protein binding; protein deacetylase activity; repressing transcription factor binding; contributes_to sequence-specific DNA binding; contributes_to transcription regulatory region DNA binding; zinc ion binding |
Product Types | ||
◆ Extracts & Lysates | ||
EL-0006 | Recombinant Human HDAC1 293 Cell Lysate | Inquiry |
EL-0007 | Recombinant Human HDAC2 293 Cell Lysate | Inquiry |
EL-0008 | Recombinant Human HDAC3 Cell Lysate | Inquiry |
EL-0009 | Recombinant Human HDAC4 Cell Lysate | Inquiry |
◆ Bioactive Small Molecules | ||
BSM-0007 | Tubacin | Inquiry |
Related Gene / Proteins | |||
HDAC | HDAC1 | HDAC10 | HDAC11 |
HDAC2 | HDAC3 | hdac4 | hdac5 |
HDAC6 | hdac7 | HDAC8 | hdac9 |
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