| Cat.No.: | PE-0057 |
| Product Name: | Recombinant Human HDAC4, His-tagged |
| Product Overview: | Recombinant fragment, corresponding to amino acids 556-1084 of Human HDAC4 with a N terminal His tag; MWt 85 kDa: |
| Description: | Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3. |
| Tissue Specificity: | Ubiquitous. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Species: | Human |
| Formulation: | Lyophilised:reconstitution with 125 μl aqua dest. |
| Tag: | His |
| Amino Acid Sequence: | VQVKQEPIESDEEEAEPPREVEPGQRQPSEQELLFRQQAL LLEQQRIHQLRNYQASMEAAGIPVSFGGHRPLSRAQSS PASATFPVSVQEPPTKPRFTTGLVYDTLMLKHQCTCGS SSSHPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEEL QTVHSEAHTLLYGTNPLNRQKLDSKKLLGSLASVFVRL PCGGVGVDSDTIWNEVHSAGAARLAVGCVVELVFKVAT GELKNGFAVVRPPGHHAEESTPMGFCYFNSVAVAAKLL QQRLSVSKILIVDWDVHHGNGTQQAFYSDPSVLYMSLHRY DDGNFFPGSGAPDEVGTGPGVGFNVNMAFTGGLDPPMG DAEYLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPT PLGGYNLSARCFGYLTKQLMGLAGGRIVLALEGGHDLTAICDASEACVSALLGNELDPLPEKVLQQRPNANAVRSMEK VMEIHSKYWRCLQRTTSTAGRSLIEAQTCENEEAETVT AMASLSVGVKPAEKRPDEEPMEEEPPL |
| Sequence Similarities: | Belongs to the histone deacetylase family. HD type 2 subfamily. |
| Expression System: | E. coli |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Gene Name: | HDAC4 histone deacetylase 4 [ Homo sapiens ] |
| Gene ID NCBI: | 9759 |
| Official Symbol: | HDAC4 |
| Synonyms: | HDAC4; histone deacetylase 4; HA6116; HD4; HDAC 4; HDAC A; HDACA; KIAA0288; |
| mRNA Refseq: | NM_006037 |
| Protein Refseq: | NP_006028 |
| MIM: | 605314 |
| UniProt ID: | P56524 |
| Chromosome Location: | 2q37.3 |
| Function: | NAD-dependent histone deacetylase activity (H3-K14 specific); NAD-dependent histone deacetylase activity (H3-K9 specific); NAD-dependent histone deacetylase activity (H4-K16 specific); activating transcription factor binding; histone deacetylase activity; |
| Product Types | ||
| ◆ Extracts & Lysates | ||
| EL-0006 | Recombinant Human HDAC1 293 Cell Lysate | Inquiry |
| EL-0007 | Recombinant Human HDAC2 293 Cell Lysate | Inquiry |
| EL-0008 | Recombinant Human HDAC3 Cell Lysate | Inquiry |
| EL-0009 | Recombinant Human HDAC4 Cell Lysate | Inquiry |
| ◆ Bioactive Small Molecules | ||
| BSM-0007 | Tubacin | Inquiry |
| Related Gene / Proteins | |||
| HDAC | HDAC1 | HDAC10 | HDAC11 |
| HDAC2 | HDAC3 | hdac4 | hdac5 |
| HDAC6 | hdac7 | HDAC8 | hdac9 |
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