| Cat.No.: | PE-0058 |
| Product Name: | Recombinant Human HDAC4 (Active), GST-tagged |
| Product Overview: | Recombinant human HDAC4 (612-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. |
| Description: | HDAC4 or Histone Deacetylase 4 belongs to class II of the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex that represses transcription when tethered to a promoter. HDAC4 does not bind DNA directly, but through transcription factors MEF2C and MEF2D. Binding of the N terminus of HDAC4 to MEF2C represses MEF2C transcription activity. The catalytic domain of HDAC4 interacts with HDAC3 via the transcriptional corepressor NCOR2. Suppression of HDAC4 binding to NCOR2 and to HDAC3 results in loss of enzymatic activity associated with HDAC4. |
| Applications: | HDAC Assay, Western Blot |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Molecular Weight: | ~77 kDa |
| Purity: | >95% |
| Species: | Human |
| Formulation: | Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol. |
| Tag: | GST |
| Activity: | 60 RLU/min/ng |
| Expression System: | Sf9 Insect Cells |
| Protein Length: | 612 aa-end |
| Concentrations: | 0.1μg/μ |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Gene Name: | HDAC4 histone deacetylase 4 [ Homo sapiens ] |
| Gene ID NCBI: | 9759 |
| Synonyms: | HDAC4; histone deacetylase 4; HA6116; HD4; HDAC 4; HDAC A; HDACA; KIAA0288; histone deacetylase A; AHO3; BDMR; HDAC-4; HDAC-A; |
| mRNA Refseq: | NM_006037 |
| Protein Refseq: | NP_006028 |
| MIM: | 605314 |
| UniProt ID: | P56524 |
| Chromosome Location: | 2q37.3 |
| Function: | NAD-dependent histone deacetylase activity (H3-K14 specific); NAD-dependent histone deacetylase activity (H3-K9 specific); NAD-dependent histone deacetylase activity (H4-K16 specific); activating transcription factor binding; histone deacetylase activity; histone deacetylase activity; histone deacetylase activity (H3-K16 specific); histone deacetylase binding; hydrolase activity; potassium ion binding; protein binding; protein deacetylase activity; protein kinase binding; repressing transcription factor binding; contributes_to sequence-specific DNA binding; transcription factor binding; contributes_to transcription regulatory region DNA binding; zinc ion binding; |
| Product Types | ||
| ◆ Extracts & Lysates | ||
| EL-0006 | Recombinant Human HDAC1 293 Cell Lysate | Inquiry |
| EL-0007 | Recombinant Human HDAC2 293 Cell Lysate | Inquiry |
| EL-0008 | Recombinant Human HDAC3 Cell Lysate | Inquiry |
| EL-0009 | Recombinant Human HDAC4 Cell Lysate | Inquiry |
| ◆ Bioactive Small Molecules | ||
| BSM-0007 | Tubacin | Inquiry |
| Related Gene / Proteins | |||
| HDAC | HDAC1 | HDAC10 | HDAC11 |
| HDAC2 | HDAC3 | hdac4 | hdac5 |
| HDAC6 | hdac7 | HDAC8 | hdac9 |
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