| Cat.No.: | PE-0096 |
| Product Name: | Recombinant Human Histone Deacetylase 8, His-tagged |
| Product Overview: | Recombinant Human histone deacetylase 8 (HDAC8) was fused to at the C-terminus to a His•Tag sequence at and expressed in S. frugiperda insect cells using a baculovirus expression system. MW = 46400 Da. |
| Description: | HDAC8 phosphorylated in vivo by PKA results in decreased activity, which leads to the hyperacetylation of histones H3 and H4. HDAC8 may play a role in one of the most frequent types of acute myeloid leukemia (AML). The active deacetylase is useful in the study of HDAC8 regulation and for inhibitor screening. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Purity: | ≥90% by SDS-PAGE. |
| Species: | Human |
| Formulation: | Liquid. In 138 mM NaCl, 25 mM Tris-HCl, 10% glycerol, 0.05% TWEEN-20 detergent, pH 8.0. Please refer to vial label for lot-specific concentration. |
| Tag: | His |
| Activity: | ≥10 units/µg protein. |
| Expression System: | S. frugiperda |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Gene Name: | HDAC8 histone deacetylase 8 [ Homo sapiens ] |
| Gene ID NCBI: | 55869 |
| Synonyms: | HDAC8; histone deacetylase-like 1; RPD3; HDACL1; histone deacetylase 8; EC 3.5.1.98; HD8 |
| mRNA Refseq: | NM_018486 |
| Protein Refseq: | NP_060956 |
| MIM: | 300269 |
| UniProt ID: | Q9BY41 |
| Chromosome Location: | Xq13 |
| Function: | histone deacetylase activity; hydrolase activity; transcription factor binding |
| Product Types | ||
| ◆ Extracts & Lysates | ||
| EL-0006 | Recombinant Human HDAC1 293 Cell Lysate | Inquiry |
| EL-0007 | Recombinant Human HDAC2 293 Cell Lysate | Inquiry |
| EL-0008 | Recombinant Human HDAC3 Cell Lysate | Inquiry |
| EL-0009 | Recombinant Human HDAC4 Cell Lysate | Inquiry |
| ◆ Bioactive Small Molecules | ||
| BSM-0007 | Tubacin | Inquiry |
| Related Gene / Proteins | |||
| HDAC | HDAC1 | HDAC10 | HDAC11 |
| HDAC2 | HDAC3 | hdac4 | hdac5 |
| HDAC6 | hdac7 | HDAC8 | hdac9 |
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