| Cat.No.: | PE-0600 |
| Product Name: | Recombinant Human Tyrosine 3-monooxygenase/ Tryptophan 5-monooxygenase Activation Protein, Beta Polypeptide |
| Product Overview: | Recombinant human 14-3-3 beta was expressed in E.coli and purified by using conventional chromatography techniques (246 aa, 28 kDa). |
| Description: | The 14-3-3 family plays a key regulatory role in signal transduction, checkpoint control, apoptotic and nutrient-sensing pathways. 14-3-3 proteins are highly conserved and ubiquitously expressed. There are at least seven isoforms, β, γ, ε, σ, ζ, τ and η that have been identified in mammals. The 14-3-3 beta, a subtype of the 14-3-3 proteins, was found in B Cells, brain and liver etc. This 14-3-3 betahas been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Molecular Weight: | 28 kDa (246 aa). |
| Purity: | > 90% by SDS – PAGE. |
| Species: | Human |
| Formulation: | Liquid. In 20 mM Tris-HCl buffer (pH 8.0) containing 1 mM EDTA, 50 mM NaCl. |
| Amino Acid Sequence: | MTMDKSELVQ KAKLAEQAER YDDMAAAMKA VTEQGHELSN EERNLLSVAY KNVVGARRSS WRVISSIEQK TERNEKKQQM GKEYREKIEA ELQDICNDVL ELLDKYLIPN ATQPESKVFY LKMKGDYFRY LSEVASGDNK QTTVSNSQQA YQEAFEISKK EMQPTHPIRL GLALNFSVFY YEILNSPEKA CSLAKTAFDE AIAELDTLNE ESYKDSTLIM QLLRDNLTLW TSENQGDEGD AGEGEN |
| Expression System: | E. coli |
| Concentrations: | 1 mg/ml (determined by Bradford assay). |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Gene Name: | YWHAB |
| Gene ID NCBI: | 7529 |
| Synonyms: | YWHAB; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide; HS1; GW128; KCIP-1; Protein 1054; OTTHUMP00000031075; OTTHUMP00000031076; 14-3-3 protein beta/alpha; Protein kinase C inhibitor protein 1; protein kinase C inhibitor protein-1; brain protein 14-3-3, beta isoform; YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide. |
| mRNA Refseq: | NM_003404.3 |
| Protein Refseq: | NP_003395.1 |
| MIM: | 601289 |
| UniProt ID: | P31946 |
| Chromosome Location: | 20q13.1 |
| Function: | enzyme binding; protein domain specific binding. |
| Product Types | ||
| ◆ Extracts & Lysates | ||
| EL-0072 | Recombinant Human YWHAB 293 Cell Lysate | Inquiry |
| EL-0073 | Recombinant Human YWHAB 293 Cell Lysate | Inquiry |
| ◆ Proteins & Enzymes | ||
| PE-0600 | Recombinant Human Tyrosine 3-monooxygenase/ Tryptophan 5-monooxygenase Activation Protein, Beta Polypeptide | Inquiry |
| PE-0601 | Recombinant Human YWHAB, GST tagged | Inquiry |
| PE-0602 | Recombinant Human YWHAB, None tagged | Inquiry |
| Related Gene / Proteins | |||
| YWHAB | |||
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