| Cat.No.: | PE-0603 |
| Product Name: | Recombinant Human Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein, Beta Polypeptide, GST-tagged |
| Product Overview: | Recombinant full-length human YWHAB was expressed in E. coli cells using a N-terminal GST tag. |
| Description: | YWHAB is a member of the highly conserved 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. YWHAB protein has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery. YWHAB interacts with the TSC1-TSC2 dimer. The interaction required phosphorylation of TSC2 at Ser1210. Binding of YWHAB to TSC2 did not alter the interaction between TSC1 and TSC2, but it reduced the ability of the complex to inhibit phosphorylation of ribosomal protein S6 kinase impairing the ability of the complex to inhibit cell growth. |
| Applications: | Western Blot |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Molecular Weight: | 54kDa |
| Purity: | >90 % |
| Species: | Human |
| Formulation: | Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM PMSF, 25% glycerol. |
| Expression System: | E. coli |
| Protein Length: | Full-length |
| Concentrations: | 0.2ug/ul |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Gene Name: | YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide [ Homo sapiens ] |
| Gene ID NCBI: | 7529 |
| Synonyms: | YWHAB; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide; HS1; GW128; KCIP-1; Protein 1054; OTTHUMP00000031075; OTTHUMP00000031076; 14-3-3 protein beta/alpha; Protein kinase C inhibitor protein 1; protein kinase C inhibitor protein-1; brain protein 14-3-3, beta isoform; YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, alpha polypeptide |
| mRNA Refseq: | NM_003404 |
| Protein Refseq: | NP_003395 |
| MIM: | 601289 |
| UniProt ID: | P31946 |
| Chromosome Location: | 20q13.1 |
| Function: | enzyme binding; protein domain specific binding; histone deacetylase binding; monooxygenase activity; phosphoprotein binding; protein C-terminus binding; protein binding; transcription corepressor activity |
| Product Types | ||
| ◆ Extracts & Lysates | ||
| EL-0072 | Recombinant Human YWHAB 293 Cell Lysate | Inquiry |
| EL-0073 | Recombinant Human YWHAB 293 Cell Lysate | Inquiry |
| ◆ Proteins & Enzymes | ||
| PE-0600 | Recombinant Human Tyrosine 3-monooxygenase/ Tryptophan 5-monooxygenase Activation Protein, Beta Polypeptide | Inquiry |
| PE-0601 | Recombinant Human YWHAB, GST tagged | Inquiry |
| PE-0602 | Recombinant Human YWHAB, None tagged | Inquiry |
| Related Gene / Proteins | |||
| YWHAB | |||
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