| Cat.No.: | PE-0696 |
| Product Name: | Recombinant Human regulatory factor X-associated ankyrin-containing protein, His-tagged |
| Product Overview: | RFXANK, 1-237aa, Human, His tag, E.coli |
| Description: | RFXANK, along with regulatory factor X-associated protein and regulatory factor-5, forms a complex that binds to the X box motif of certain MHC class II gene promoters and activates their transcription. Once bound to the promoter, this complex associates with the non-DNA-binding factor MHC class II transactivator, which controls the cell type specificity and inducibility of MHC class II gene expression. This protein contains ankyrin repeats involved in protein-protein interactions. Mutations in this gene have been linked to bare lymphocyte syndrome type II, complementation group B. Two transcript variants encoding different isoforms have been described for this gene, with only one isoform showing activation activity. Recombinant human RFXANK protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Molecular Weight: | 28 kDa (260aa), confirmed by MALDI-TOF |
| Purity: | >85% by SDS - PAGE |
| Species: | Human |
| Formulation: | Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 20% glycerol. |
| Tag: | His |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMELTQPA EDLIQTQQTP ASELGDPEDP GEEAADGSDT VVLSLFPCTP EPVNPEPDAS VSSPQGSSLK HSTTLTNRQR GNEVSALPAT LDCDNLVNKP DERGFTPLIW ASAFGEIETV RFLLEWGADP HILAKERESA LSLASTGGYT DIVGLLLERD VDINIYDWNG GTPLLYAVRG NHVKCVEALL ARGADLTTEA DSGYTPMDLA VALGYRKVQQ VIENHILKLF QSNLVPADPE |
| Expression System: | E. coli |
| Concentrations: | 0.25 mg/ml (determined by Bradford assay) |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Gene Name: | RFXANK regulatory factor X-associated ankyrin-containing protein [ Homo sapiens ] |
| Gene ID NCBI: | 8625 |
| Synonyms: | RFXANK; regulatory factor X-associated ankyrin-containing protein; DNA-binding protein RFXANK; ANKRA1; ankyrin repeat containing regulatory factor X associated protein; BLS; DNA binding protein RFXANK; F14150_1; MGC138628; regulatory factor X subunit B; RFX B; RFX Bdelta4; RFX-Bdelta4; ankyrin repeat family A protein 1; ankyrin repeat-containing regulatory factor X-associated protein; RFX-B; |
| mRNA Refseq: | NM_003721 |
| Protein Refseq: | NP_003712 |
| MIM: | 603200 |
| UniProt ID: | O14593 |
| Chromosome Location: | 19p12 |
| Function: | DNA binding; histone deacetylase binding; sequence-specific DNA binding transcription factor activity; transcription cofactor activity; |
| Product Types | ||
| ◆ Extracts & Lysates | ||
| EL-0083 | Recombinant Human RFXANK 293 Cell Lysate | Inquiry |
| EL-0084 | Recombinant Human RFXANK 293 Cell Lysate | Inquiry |
| ◆ Cell Lines | ||
| CL-0147 | Human RFWD3 Knockout Cell Line 13bp deletion | Inquiry |
| ◆ Proteins & Enzymes | ||
| PE-0695 | Recombinant Human RFXANK, His-tagged | Inquiry |
| PE-0696 | Recombinant Human regulatory factor X-associated ankyrin-containing protein, His-tagged | Inquiry |
| Related Gene / Proteins | |||
| RFPL3 | RFWD3 | RFXANK | |
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