| Cat.No.: | PE-0759 |
| Product Name: | Recombinant Human X-Box Binding Protein 1, His-tagged |
| Product Overview: | Recombinant Human X-box binding protein 1 was expressed in E.Coli using an N-terminal His tag. MW=25 kDa. |
| Description: | X box binding protein 1 (XBP-1) is a key protein in the mammalian unfolded protein response (UPR) that protects the cell against the stress of malfolded proteins in the endoplasmic reticulum (ER). Upon sensing unfolded proteins, an ER transmembrane endonuclease and kinase termed IRE1p is activated and excises an intron from XBP-1 mRNA. The spliced XBP-1 mRNA results in a 371 amino acid protein (XBP-1s) which is then translocated to the nucleus where it binds to the regulatory elements of downstream genes. Together with other UPR transcription factors such as ATF6, XBP-1 stimulates the production of ER stress proteins including the ER resident protein chaperones glucose regulated protein (GRP) 78 and GRP94. |
| Applications: | This recombinant protein can be used for WB, ELISA, MS and neutralization assays. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Purity: | ~95%. |
| Species: | Human |
| Tag: | His |
| Expression System: | E. coli |
| Protein Length: | 2 - 160. |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Gene Name: | XBP1 X-box binding protein 1 [ Homo sapiens ] |
| Gene ID NCBI: | 7494 |
| Synonyms: | XBP1; X-box binding protein 1; XBP2; TREB5; X-box-binding protein 1; Tax-responsive element-binding protein 5; XBP-1 |
| mRNA Refseq: | NM_001079539 |
| Protein Refseq: | NP_001073007 |
| MIM: | 194355 |
| Chromosome Location: | 22q12.1 |
| Function: | protein dimerization activity; sequence-specific DNA binding; transcription factor activity |
| Product Types | ||
| ◆ Extracts & Lysates | ||
| EL-0095 | Recombinant Human XBP1 293 Cell Lysate | Inquiry |
| ◆ Research Kits | ||
| EKIT-0272 | XBP1 Nuclear Translocation Assay Kit | Inquiry |
| ◆ Proteins & Enzymes | ||
| PE-0759 | Recombinant Human X-Box Binding Protein 1, His-tagged | Inquiry |
| PE-0760 | Recombinant Human X-Box Binding Protein 1, T7-tagged | Inquiry |
| PE-0761 | Recombinant Human XBP1, T7 -tagged | Inquiry |
| Related Gene / Proteins | |||
| xbp1 | |||
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