Cat.No.: | PE-0814 |
Product Name: | Recombinant Human Proliferating Cell Nuclear Antigen |
Product Overview: | Recombinant human Proliferating Cell Nuclear Antigen, was expressed in E.coli and purified by conventional chromatography techniques. MW = 28 kDa (261 aa). |
Description: | PCNA (Proliferating Cell Nuclear Antigen) is found in the nucleus and is a cofactor of DNA polymerase delta. This protein is associated with DNA synthesis and repair. The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. It appears during late G1- phase, S-phase of mitosis and persists until the end of the M-phase because of its long biological half-life. PCNA may be induced by UV irradiation, growth factors and eventually by neighbouring tumours. |
Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
Purity: | > 95% by SDS - PAGE. |
Species: | Human |
Formulation: | Liquid. In 20 mM Tris-HCl buffer (pH 7.5) containing 2 mM EDTA 20% glycerol. |
Amino Acid Sequence: | MFEARLVQGS ILKKVLEALK DLINEACWDI SSSGVNLQSM DSSHVSLVQL TLR SEG FDTY RCDRNLAMGV NLTSMSKILK CAGNEDIITL RAEDNADTLA LVF EAP NQE K VSDYEMKLMD LDVEQLGIPE QEYSCVVKMP SGEFARICRD LSHIGDAVVI SCAKDGVKFS ASGELGNGNI KLSQTSNVDK EEEAVTIEMN EPVQLTFALR YLN FFTKATP LSSTVTLSMS ADVPLVVEYK IADMGHLKYY LAPKIEDEEG S. |
Expression System: | E. coli |
Concentrations: | 1 mg/ml (determined by Bradford assay). |
Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Gene Name: | PCNA proliferating cell nuclear antigen [ Homo sapiens ] |
Gene ID NCBI: | 5111 |
Synonyms: | MGC8367; PCNA; Proliferating cell nuclear antigen; Cyclin; proliferating cell nuclear antigen; cyclin; DNA polymerase delta auxiliary protein |
mRNA Refseq: | NM_002592 |
Protein Refseq: | NP_002583 |
MIM: | 176740 |
UniProt ID: | P12004 |
Chromosome Location: | 20pter-p12 |
Function: | DNA binding; DNA polymerase processivity factor activity; MutLalpha complex binding; dinucleotide insertion or deletion binding; protein binding; purine-specific mismatch base pair DNA N-glycosylase activity |
Product Types | ||
◆ Bioactive Small Molecules | ||
BSM-0039 | Embelin | Inquiry |
BSM-0108 | Curcumin, Curcuma longa (High Purity) | Inquiry |
BSM-0133 | Garcinol | Inquiry |
◆ Antibodies | ||
EAb-0060 | PCAF Polyclonal Antibody | Inquiry |
◆ Extracts & Lysates | ||
EL-0106 | Recombinant Human PCNA Cell Lysate | Inquiry |
Related Gene / Proteins | |||
PCAF | PCBP2 | PCBP3 | PCBP4 |
PCGF2 | PCGF6 | PCL2 | PCNA |
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