| Cat.No.: | PE-0834 |
| Product Name: | Recombinant Mouse Trp53 protein, His-tagged |
| Product Overview: | Recombinant Mouse Trp53 aa. (Thr134~Asp387) fused with N-terminal His tag was produced in E. coli cells. |
| Description: | This gene encodes tumor protein p53, which responds to diverse cellular stresses to regulate target genes that induce cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it's believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing transcription activation, DNA-binding, and oligomerization domains. It is postulated to bind to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Mice deficient for this gene are developmentally normal but are susceptible to spontaneous tumors. Evidence to date shows that this gene contains one promoter, in contrast to alternative promoters of the human gene, and transcribes a few of splice variants which encode different isoforms, although the biological validity or the full-length nature of some variants has not been determined. |
| Applications: | SDS-PAGE; WB; ELISA; IP; CoIP; Purification; Amine Reactive Labeling. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Appearance: | Freeze-dried powder |
| Molecular Weight: | 34kDa as determined by SDS-PAGE reducing conditions. |
| Purity: | >98% |
| Species: | Mouse |
| Tag: | His |
| Endotoxin: | <1.0EU per 1µg (determined by the LAL method) |
| Reconstitution: | Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex. |
| Expression System: | E. coli |
| Isoelectric Point: | The isoelectric point is 9. |
| Protein Length: | Thr134~Asp387 |
| Concentrations: | 200μg/mL |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Gene Name: | Trp53 transformation related protein 53 [ Mus musculus (house mouse) ] |
| Gene ID NCBI: | 22059 |
| Official Symbol: | Trp53 |
| Synonyms: | Trp53; transformation related protein 53; bbl; bfy; bhy; p44; p53; Tp53; cellular tumor antigen p53; mutant p53; p53 cellular tumor antigen; tumor suppressor p53; tumor supressor p53 |
| mRNA Refseq: | NM_001127233.1 |
| Protein Refseq: | NP_001120705.1 |
| UniProt ID: | P02340 |
| Product Types | ||
| ◆ Antibodies | ||
| EAb-0013 | TP2 Polyclonal Antibody | Inquiry |
| EAb-0623 | p53 Monoclonal Antibody | Inquiry |
| ◆ Bioactive Small Molecules | ||
| BSM-0053 | UNC-2170 | Inquiry |
| BSM-0324 | UNC2170 (maleate) | Inquiry |
| ◆ Cell Lines | ||
| CL-0438 | Human TP53BP1 Knockout Cell Line 40bp deletion | Inquiry |
| Related Gene / Proteins | |||
| TP2 | TP53BP1 | ||
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