| Cat.No.: | PE-1135 |
| Product Name: | Recombinant Human KDM1A |
| Product Overview: | Recombinant fragment corresponding to amino acids 158-852 of Human KDM1 / LSD1 with N-terminal proprietary tag, 103 kDa. |
| Description: | This gene encodes a nuclear protein containing a SWIRM domain, a FAD-binding motif, and an amine oxidase domain. This protein is a component of several histone deacetylase complexes, though it silences genes by functioning as a histone demethylase. Alternative splicing results in multiple transcript variants. |
| Tissue Specificity: | Ubiquitously expressed. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Appearance: | Liquid |
| Species: | Human |
| Sequence Similarities: | Belongs to the flavin monoamine oxidase family.Contains 1 SWIRM domain. |
| Activity: | Specific Activity: 0.82 pmole/min/μg.Assay buffer: 50 mM sodium phosphate, pH 7.4, 70 uM dimethylated H3-K4 peptide and 8 ng/ul recombinant KDM1 / LSD1, 30 min at 37℃. |
| Expression System: | E. coli |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Gene Name: | KDM1A lysine (K)-specific demethylase 1A [ Homo sapiens ] |
| Gene ID NCBI: | 23028 |
| Official Symbol: | KDM1A |
| Synonyms: | KDM1A; lysine (K)-specific demethylase 1A; amine oxidase (flavin containing) domain 2 , AOF2, KDM1, lysine (K) specific demethylase 1; lysine-specific histone demethylase 1A; BHC110; KIAA0601; LSD1; |
| mRNA Refseq: | NM_001009999 |
| Protein Refseq: | NP_001009999 |
| MIM: | 609132 |
| UniProt ID: | O60341 |
| Chromosome Location: | 1p36.12 |
| Function: | MyoD binding; androgen receptor binding; chromatin binding; demethylase activity; enzyme binding; |
| Product Types | ||
| ◆ Cell Lines | ||
| CL-0015 | Human KDM5B Knockout Cell Line 14bp deletion | Inquiry |
| CL-0087 | Human KDM1A Knockout Cell Line 10bp deletion | Inquiry |
| CL-0088 | Human KDM1B Knockout Cell Line 13bp deletion | Inquiry |
| CL-0089 | Human KDM2B Knockout Cell Line 14bp deletion | Inquiry |
| ◆ Antibodies | ||
| EAb-0071 | KDM1B Polyclonal Antibody | Inquiry |
| Related Gene / Proteins | |||
| KDM1 | KDM1A | KDM1B | KDM2 |
| KDM2A | KDM2B | KDM3A | KDM3B |
| KDM4 | KDM4A | KDM4B | KDM4C |
| KDM4D | KDM4E | KDM5 | KDM5A |
| KDM5B | KDM5C | KDM5D | KDM6A More > |
| KDM6B | KDM6C | KDM7 | KDM7A |
| KDM7B | KDM8 | ||
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