| Cat.No.: | PE-1888 |
| Product Name: | Gcn5 (human recombinant) |
| Description: | Gcn5 and PCAF are highly homologous members of the Gcn5-related N-acetyltransferase (GNAT) superfamily of N-acetyltransferases involved in histone acetylation. Gcn5 and PCAF contain a highly conserved central core with divergent N- and C-terminal ends. Gcn5/PCAF are enzymatic subunits that exist in a mutually exclusive manner as part of the mammalian SAGA and ATAC complexes. Recombinant Gcn5 preferentially acetylates lysine 14 on histone H3 in vitro. Recombinant Gcn5 alone is unable to acetylate nucleosomal core histone substrates. Acetylation of the nucleosomal histones requires that Gcn5 be a part of either the multisubunit SAGA or ATAC protein complexes. The multisubunit Gcn5/PCAF-containing complexes have a broad substrate specificity, including H3K9, H3K18, H4K8, and H4K16, as well as additional sites on histone H2B. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Molecular Weight: | 96.3 kDa |
| Purity: | ≥50 % (by SDS-PAGE) |
| Species: | human |
| Formulation: | 50 mM Tris-HCl, pH 8.0, containing 150 mM sodium chloride and 20% glycerol |
| Accession#: | Q92830 |
| Alternative Names: | General control of amino acid synthesis protein 5-like 2;KAT2A;Lysine acetyltransferase 2A;STAF97 |
| Tag: | His |
| Expression System: | Sf21 Insect Cells |
| Protein Length: | 2-837 (full-length) |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Product Types | ||
| ◆ Bioactive Small Molecules | ||
| BSM-0037 | CPTH2 | Inquiry |
| BSM-0298 | CPTH2 (hydrochloride) | Inquiry |
| BSM-0299 | Butyrolactone 3 | Inquiry |
| BSM-0354 | CPTH6 (hydrobromide) | Inquiry |
| ◆ Research Kits | ||
| EKIT-0188 | GCN5 Chemiluminescent Assay Kit | Inquiry |
| Related Gene / Proteins | |||
| GCN5 | |||
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