Cat.No.: | PE-2627 |
Product Name: | Recombinant Human MCM6 protein |
Background: | Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. |
Applications: | ELISA; SDS-PAGE; Western blot |
Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
Appearance: | Liquid |
Molecular Weight: | 116 kDa including tags |
Species: | Human |
Formulation: | pH: 8.00; Constituents: 0.3% Glutathione, 0.79% Tris HCl |
Accession#: | Q14566 |
Alternative Names: | DNA replication licensing factor MCM6/MCG40308/Mcm6 |
Amino Acid Sequence: | MDLAAAAEPGAGSQHLEVRDEVAEKCQKLFLDFLEEFQSSDGEIKYLQLA EELIRPERNTLVVSFVDLEQFNQQLSTTIQEEFYRVYPYLCRALKTFVKD RKEIPLAKDFYVAFQDLPTRHKIRELTSSRIGLLTRISGQVVRTHPVHPE LVSGTFLCLDCQTVIRDVEQQFKYTQPNICRNPVCANRRRFLLDTNKSRF VDFQKVRIQETQAELPRGSIPRSLEVILRAEAVESAQAGDKCDFTGTLIV VPDVSKLSTPGARAETNSRVSGVDGYETEGIRGLRALGVRDLSYRLVFLA CCVAPTNPRFGGKELRDEEQTAESIKNQMTVKEWEKVFEMSQDKNLYHNL CTSLFPTIHGNDEVKRGVLLMLFGGVPKTTGEGTSLRGDINVCIVGDPST AKSQFLKHVEEFSPRAVYTSGKASSAAGLTAAVVRDEESHEFVIEAGALM LADNGVCCIDEFDKMDVRDQVAIHEAMEQQTISITKAGVKATLNARTSIL AAANPISGHYDRSKSLKQNINLSAPIMSRFDLFFILVDECNEVTDYAIAR RIVDLHSRIEESIDRVYSLDDIRRYLLFARQFKPKISKESEDFIVEQYKH LRQRDGSGVTKSSWRITVRQLESMIRLSEAMARMHCCDEVQPKHVKEAFR LLNKSIIRVETPDVNLDQEEEIQMEVDEGAGGINGHADSPAPVNGINGYN EDINQESAPKASLRLGFSEYCRISNLIVLHLRKVEEEEDESALKRSELVN WYLKEIESEIDSEEELINKKRIIEKVIHRLTHYDHVLIELTQAGLKGSTE GSESYEEDPYLVVNPNYLLED |
Sequence Similarities: | Belongs to the MCM family.Contains 1 MCM domain. |
Expression System: | Wheat germ |
Post Translational Modifications: | Phosphorylated upon DNA damage, probably by ATM or ATR. |
Protein Length: | Full length protein; 1 to 821 |
Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Product Types | ||
◆ Cell Lines | ||
CL-0011 | Human MCF2L Knockout Cell Line | Inquiry |
◆ Antibodies | ||
EAb-0068 | MCAF Polyclonal Antibody | Inquiry |
EAb-0303 | MCM6 Polyclonal Antibody | Inquiry |
◆ Extracts & Lysates | ||
EL-0161 | Recombinant Human MCRS1 293 Cell Lysate | Inquiry |
◆ Proteins & Enzymes | ||
PE-1225 | Recombinant Human MCRS1, His-tagged | Inquiry |
Related Gene / Proteins | |||
MCAF1 | MCF2L | MCM6 | MCM8 |
MCRS1 |
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