| Cat.No.: | EKIT-0541 |
| Product Name: | PROTAC Optimization Kit for BET Bromodomain-Cereblon Binding |
| Size: | 384 reactions |
| Description: | The PROTAC Optimization Kit for BET Bromodomain-Cereblon Binding isdesigned for testing and profiling of PROTACs directed against BET Bromodomain family andCereblon complex. Cereblon (CRBN) is a Substrate recognition component of a DCX (DDB1-CUL44-Rbx1) E3 protein ligase complex that mediates the ubiquitination and subsequentproteasomal degradation of target proteins. The PROTAC Optimization Kit for BET Bromodomain-Cereblon Binding comes in a convenientAlphaLISA format, with dBET1 PROTAC, Immuno Buffer 1, and purified BRD3(BD2) and CRBNfor 384 reactions. (+)JQ1 is included as a control inhibitor of PROTAC binding to BRD3(BD2).With this kit, only three simple steps on a microtiter plate are required for PROTAC activitydetection. First, a sample containing PROTAC is incubated with CRBN and BRD3(BD2), one ofBET bromodomains. Next, acceptor beads are added, then donor beads, followed by reading theAlpha-counts. |
| Kit Components: | Great for search of proper PROTACs targeting BET family of bromodomains, design of novel molecules targeting CRBN, and comparison of activities of different PROTACs. |
| Warning: | For research use only, not for diagnostic use. |
USA
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