| Cat.No.: | BSM-0323 |
| Product Name: | BMS 345541 (trifluoroacetate salt) |
| Figure: |
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| Synonyms: | IKK Inhibitor III |
| Product Overview: | A selective inhibitor of IKKα and IKKβ |
| Description: | BMS 345541 is a cell permeable inhibitor of the IκB kinases IKKα and IKKβ (IC50s = 4 and 0.3 µM). It is without effect against a panel of other serine/threonine and tyrosine kinases at 100 µM. BMS 345541 inhibits signaling through nuclear factor-κB (NF-κB) both in cells and in vivo, showing excellent pharmacokinetics in mice. It blocks joint inflammation and damage in collagen-induced arthritis in mice and induces apoptosis in melanoma cells both in vitro and in vivo. BMS 345541 is used to explore novel roles for IKK phosphorylation and NF-κB signaling. |
| Appearance: | A crystalline solid |
| Molecular Weight: | 483.4 |
| Purity: | ≥98% |
| Storage: | -20°C |
| Targets: | IKKα and IKKβ |
| Molecular Formula: | C14H17N5 • 2CF3COOH |
| Chemical Name: | N1-(1,8-dimethylimidazo[1,2-a]quinoxalin-4-yl)-1,2-ethanediamine, trifluoroacetate salt |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Product Types | ||
| ◆ Cell Lines | ||
| CL-0052 | Human IKBKG Knockout Cell Line 269bp insertion | Inquiry |
| ◆ Bioactive Small Molecules | ||
| BSM-0323 | BMS 345541 (trifluoroacetate salt) | Inquiry |
| ◆ Antibodies | ||
| EAb-1951 | IKKγ Monoclonal Antibody | Inquiry |
| EAb-1952 | IKKi/IKKε Polyclonal Antibody | Inquiry |
| EAb-1953 | IKKβ Monoclonal Antibody | Inquiry |
| Related Gene / Proteins | |||
| Ikaros | IKBKG | IKK | |
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