| Cat.No.: | EAb-1951 |
| Product Name: | IKKγ Monoclonal Antibody |
| Antibody Type: | Monoclonal |
| Immunogen: | This IKKγ antibody was raised against a full-length protein corresponding to human IKKγ. |
| Host: | Mouse |
| Isotype: | IgG1 |
| Molecular Weight: | 48 kDa |
| Purification: | Affinity Purified |
| Appearance: | Liquid |
| Formulation: | PBS containing 0.02% sodium azide. |
| Applications: | WB: 1 - 2 µg/ml dilution^Recommended dilutions/conditions may not be available for all applications. Specific conditions for reactivity should be optimized by the end user. |
| Species Reactivity: | Human |
| Storage: | -20°C |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Scientific Background: | The IκB Kinase (IKK) complex is the key enzyme involved in the activation and translocation of NFκB (NFκB p50 & NFκB p65). The IKK complex is composed of two catalytic subunits (IKKα and IKKβ) and a regulatory subunit (IKKγ).NFκB signaling is negatively regulated by the sequestration of the NFκB complex in the cytoplasm by its association with the IκB family of inhibitory proteins. Upon its activation, the IKK complex phosphorylates IκBα at Ser32 and Ser36. This results ultimately in the degradation of IκB and the activation and nuclear translocation of NFκB. While both IKK-alpha and IKK-beta subunits are Ser/Thr kinases, IKK beta appears to be the principal kinase, as IKKα is not required for activation of the IKK complex and the subsequent degradation of IκBα. Once activated, IKKβ autophosphorylates, which decreases IKK activity, thereby preventing a prolonged activation of inflammation. |
| Product Types | ||
| ◆ Cell Lines | ||
| CL-0052 | Human IKBKG Knockout Cell Line 269bp insertion | Inquiry |
| ◆ Bioactive Small Molecules | ||
| BSM-0323 | BMS 345541 (trifluoroacetate salt) | Inquiry |
| ◆ Antibodies | ||
| EAb-1951 | IKKγ Monoclonal Antibody | Inquiry |
| EAb-1952 | IKKi/IKKε Polyclonal Antibody | Inquiry |
| EAb-1953 | IKKβ Monoclonal Antibody | Inquiry |
| Related Gene / Proteins | |||
| Ikaros | IKBKG | IKK | |
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