Cat.No.: | EL-0078 |
Product Name: | Recombinant Human PKN1 Cell Lysate |
Description: | The protein encoded by this gene belongs to the protein kinase C superfamily. This kinase is activated by Rho family of small G proteins and may mediate the Rho-dependent signaling pathway. This kinase can be activated by phospholipids and by limited proteolysis. The 3-phosphoinositide dependent protein kinase-1 (PDPK1/PDK1) is reported to phosphorylate this kinase, which may mediate insulin signals to the actin cytoskeleton. The proteolytic activation of this kinase by caspase-3 or related proteases during apoptosis suggests its role in signal transduction related to apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed. |
Species: | Human |
Warning: | For research use only, not for diagnostic or therapeutic use. |
Gene ID NCBI: | 5585 |
Official Symbol: | PKN1 |
Official Full Name: | protein kinase N1 |
Synonyms: | PKN1; protein kinase N1; PRKCL1, protein kinase C like 1; serine/threonine-protein kinase N1; DBK; MGC46204; PAK1; PKN; PRK1; protein kinase C-like 1; protein kinase PKN-alpha; protein kinase C-like PKN; serine-threonine kinase N; protease-activated kinase 1; protein kinase C-related kinase 1; protein-kinase C-related kinase 1; serine-threonine protein kinase N; serine/threonine protein kinase N; PAK-1; PRKCL1; PKN-ALPHA; |
mRNA Refseq: | NM_002741 |
Protein Refseq: | NP_002732 |
MIM: | 601032 |
UniProt ID: | Q16512 |
Chromosome Location: | 19p13.12 |
Function: | ATP binding; GTP-Rho binding; Rac GTPase binding; androgen receptor binding; chromatin binding; histone binding; histone deacetylase binding; histone kinase activity (H3-T11 specific); ligand-dependent nuclear receptor transcription coactivator activity; ligand-dependent nuclear receptor transcription coactivator activity; nucleotide binding; protein binding; protein kinase C activity; protein kinase C binding; protein kinase activity; protein serine/threonine kinase activity; |
Product Types | ||
◆ Antibodies | ||
EAb-0054 | PKC Polyclonal Antibody | Inquiry |
EAb-0183 | PKM Polyclonal Antibody | Inquiry |
◆ Extracts & Lysates | ||
EL-0078 | Recombinant Human PKN1 Cell Lysate | Inquiry |
EL-0086 | Recombinant Human PKN2 293 Cell Lysate | Inquiry |
◆ Bioactive Small Molecules | ||
BSM-0203 | Ro 31-8220 methanesulfonate | Inquiry |
Related Gene / Proteins | |||
PKC | PKM | PKM2 | PKN1 |
PKN2 |
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