| Cat.No.: | EL-0368 |
| Product Name: | MDA-MB-231 nuclear extract |
| Description: | MDA-MB-231 nuclear extract was prepared from cell cultures of the human breast adenocarcinoma MDA-MB-231 cell line. The MDA-MB-231 cell line was derived from a pleural effusion of a 51 year old Caucasian female with an intraductal carcinoma. Although MDA-MB-231 cells are epithelial in morphology, they display a mesenchymal-like/ER-negative/ERBB2-negative phenotype. These cells are characterized by the expression of epidermal growth factor receptor (EGFR) and transforming growth factor α receptor (TGFRα). EGFR and TGFR are receptors that are most commonly associated with human tumorigenesis. Interestingly, although MDA-MB-231 cells express EGFR, they lack a proliferative response to EGF. MDA-MB-231 cells are most frequently used in research as a model for breast adenocarcinoma. |
| Species: | Human |
| Source: | Human breast adenocarcinoma mammary gland |
| Components: | 200 µg of MDA-MB-231 nuclear extract at 6.8 µg/µl. |
| Extract Composition: | MDA-MB-231 nuclear extract is supplied in Dilution Buffer (20 mM Hepes (pH 7.9), 100 mM KCl, 1 mM MgCl2, 20% glycerol, 0.5 mM PMSF and 0.5 mM DTT). |
| Application Notes: | MDA-MB-231 nuclear extract is specifically recommended for breast cancer studies. |
| Storage: | Store at -80°C. Aliquot to avoid repeated freezing and thawing. |
| Warning: | For research use only, not for diagnostic or therapeutic use. |
| Product Types | ||
| ◆ Extracts & Lysates | ||
| EL-0001 | Recombinant Human MBD1 Cell Lysate | Inquiry |
| EL-0002 | Recombinant Human MBD3 Cell Lysate | Inquiry |
| EL-0003 | Recombinant Human MBD3L1 293 Cell Lysate | Inquiry |
| EL-0004 | Recombinant Human MBD4 Lysate | Inquiry |
| EL-0005 | Recombinant Human MBD5 Cell Lysate | Inquiry |
USA
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