| Cat.No.: | EAb-0046 |
| Product Name: | PTP1B Polyclonal Antibody |
| Antibody Type: | Polyclonal |
| Immunogen: | Recombinant protein encoding amino acids 1-321 of human PTP1B |
| Host: | Rabbit |
| Isotype: | IgG |
| Antibody Target: | PTP1B |
| Purification: | Affinity purified |
| Appearance: | Colorless liquid |
| Formulation: | 100 µg (0.25 mg/ml) purified rabbit Ig polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. |
| Applications: | ELISA, Western blot |
| Recommended Dilutions/Conditions: |
The antibody can be used for ELISA (0.25 µg/ml), Western blotting (0.5 – 2.5 µg/ml). Recommended dilutions/conditions may not be available for all applications. Specific conditions for reactivity should be optimized by the end user. |
| Species Reactivity: | Human, mouse |
| Shipping: | Gel Pack |
| Storage: | -20°C |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Accession: | P18031 |
| Scientific Background: | PTP1B is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation. |
| Product Types | ||
| ◆ Antibodies | ||
| EAb-0045 | PTP1B Monoclonal Antibody | Inquiry |
| EAb-0046 | PTP1B Polyclonal Antibody | Inquiry |
| EAb-0047 | PTP1B Polyclonal Antibody | Inquiry |
| EAb-0310 | PTBP1 Polyclonal Antibody | Inquiry |
| ◆ Cell Lines | ||
| CL-0196 | Human PTCHD2 Knockout Cell Line | Inquiry |
| Related Gene / Proteins | |||
| PTBP1 | PTBP2 | PTCHD2 | PTP1B |
USA
Enter your email here to subscribe.
Follow us on
Easy access to products and services you need from our library via powerful searching tools
