| Cat.No.: | EAb-0310 |
| Product Name: | PTBP1 Polyclonal Antibody |
| Antibody Type: | Polyclonal |
| Immunogen: | Recombinant protein of human PTBP1 |
| Host: | Rabbit |
| Isotype: | IgG |
| Purification: | Affinity purification |
| Appearance: | Liquid |
| Applications: | WB |
| Recommended Dilutions/Conditions: |
WB: 1:500 - 1:2000 Recommended dilutions/conditions may not be available for all applications. Specific conditions for reactivity should be optimized by the end user. |
| Species Reactivity: | Human, Mouse |
| Storage: | -20°C |
| Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Accession: | P26599 |
| Alternative Name: | 57 kDa RNA binding protein PPTB 1,57 kDa RNA-binding protein PPTB-1,Heterogeneous nuclear ribonucleoprotein I,Heterogeneous Nuclear Ribonucleoprotein Polypeptide I,hnRNP I,HNRNP-I,HNRNPI,HNRPI,MGC10830,MGC8461,Polypyrimidine tract binding protein (heterogeneous nuclear ribonucleoprotein I),Polypyrimidine Tract Binding Protein 1,Polypyrimidine tract binding protein,Polypyrimidine tract-binding protein 1,pPTB,PTB 1,PTB 2,PTB 3,PTB 4,PTB,PTB T,PTB1,PTB2,PTB3,PTB4,PTBP 1,PTBP1,PTBP1,PTBT,RNA Binding Protein |
| Scientific Background: | This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA-binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has four repeats of quasi-RNA recognition motif (RRM) domains that bind RNAs. This protein binds to the intronic polypyrimidine tracts that requires pre-mRNA splicing and acts via the protein degradation ubiquitin-proteasome pathway. It may also promote the binding of U2 snRNP to pre-mRNAs. This protein is localized in the nucleoplasm and it is also detected in the perinucleolar structure. Alternatively spliced transcript variants encoding different isoforms have been described. |
| Product Types | ||
| ◆ Antibodies | ||
| EAb-0045 | PTP1B Monoclonal Antibody | Inquiry |
| EAb-0046 | PTP1B Polyclonal Antibody | Inquiry |
| EAb-0047 | PTP1B Polyclonal Antibody | Inquiry |
| EAb-0310 | PTBP1 Polyclonal Antibody | Inquiry |
| ◆ Cell Lines | ||
| CL-0196 | Human PTCHD2 Knockout Cell Line | Inquiry |
| Related Gene / Proteins | |||
| PTBP1 | PTBP2 | PTCHD2 | PTP1B |
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