| Cat.No.: | EAb-0313 |
| Product Name: | RUNX2 Polyclonal Antibody |
| Antibody Type: | Polyclonal |
| Immunogen: | Recombinant protein of human RUNX2 |
| Host: | Rabbit |
| Isotype: | IgG |
| Purification: | Affinity purification |
| Appearance: | Liquid |
| Applications: | WB |
| Recommended Dilutions/Conditions: |
WB: 1:200 - 1:1000 Recommended dilutions/conditions may not be available for all applications. Specific conditions for reactivity should be optimized by the end user. |
| Species Reactivity: | Human, Mouse |
| Storage: | -20°C |
| Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Accession: | Q13950 |
| Alternative Name: | Acute myeloid leukemia 3 protein,Alpha subunit 1,AML3,CBF alpha 1,CBF-alpha-1,CBFA1,CCD,CCD1,Cleidocranial dysplasia 1,Core binding factor,Core binding factor runt domain alpha subunit 1,Core binding factor subunit alpha 1,Core-binding factor subunit alpha-1,MGC120022,MGC120023,Oncogene AML 3,Oncogene AML-3,OSF 2,OSF-2,OSF2,Osteoblast specific transcription factor 2,Osteoblast-specific transcription factor 2,OTTHUMP00000016533,PEA2 alpha A,PEA2-alpha A,PEA2aA,PEBP2 alpha A,PEBP2-alpha A,PEBP2A1,PEBP2A2,PEBP2aA,PEBP2aA1,Polyomavirus enhancer binding protein 2 alpha A subunit,Polyomavirus enhancer-binding protein 2 alpha A subunit,Runt domain,Runt related transcription factor 2,Runt-related transcription factor 2,RUNX2,RUNX2,SL3 3 enhancer factor 1 alpha A subunit,SL3-3 enhancer factor 1 alpha A subunit,SL3/AKV core binding factor alpha A subunit,SL3/AKV core-binding factor alpha A subunit |
| Scientific Background: | This gene is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Two regions of potential trinucleotide repeat expansions are present in the N-terminal region of the encoded protein, and these and other mutations in this gene have been associated with the bone development disorder cleidocranial dysplasia (CCD). Transcript variants that encode different protein isoforms result from the use of alternate promoters as well as alternate splicing. |
| Product Types | ||
| ◆ Antibodies | ||
| EAb-0042 | Runx1/AML1-ETO Polyclonal Antibody | Inquiry |
| EAb-0313 | RUNX2 Polyclonal Antibody | Inquiry |
| ◆ Extracts & Lysates | ||
| EL-0092 | Recombinant Human RUNX2 293 Cell Lysate | Inquiry |
| EL-0093 | Recombinant Human RUNX2 293 Cell Lysate | Inquiry |
| ◆ Proteins & Enzymes | ||
| PE-0746 | Recombinant Human RUNX2 | Inquiry |
| Related Gene / Proteins | |||
| Runx1 | RUNX2 | RUVB2 | RUVBL1 |
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