KEAP1 Polyclonal Antibody


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Cat.No.:  EAb-0320
Product Name:  KEAP1 Polyclonal Antibody
Antibody Type:  Polyclonal
Immunogen:  Recombinant protein of human KEAP1
Host:  Rabbit
Isotype:  IgG
Purification:  Affinity purification
Appearance:  Liquid
Applications:  WB, IHC, IF
Recommended Dilutions/Conditions:  WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:50 - 1:200
Recommended dilutions/conditions may not be available for all applications. Specific conditions for reactivity should be optimized by the end user.
Species Reactivity:  Human, Rat
Storage:  -20°C
Storage Buffer:  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Warning:  For Research Use Only! Not For Use in Humans.
Accession:  Q14145
Alternative Name:  Cytosolic inhibitor of Nrf2,INrf 2,INrf2,Keap 1,KEAP1,KEAP1,Kelch like ECH associated protein 1,Kelch like family member 19,Kelch like protein 19,Kelch-like ECH-associated protein 1,Kelch-like protein 19,KIAA0132,KLHL 19,KLHL19,MGC10630,MGC1114,MGC20887,MGC4407,MGC9454
Scientific Background:  This gene encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase. Two alternatively spliced transcript variants encoding the same isoform have been found for this gene.

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For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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