| Cat.No.: | PE-0587 |
| Product Name: | Recombinant Human TOP2A, GST-tagged |
| Product Overview: | Recombinant Human HTR2A encoding human TOP2Apartial ORF (1435 a.a. - 1531 a.a.) fused with a GST-tag at N-terminal was produced in Wheatgerm expression system. |
| Description: | This gene encodes a DNA topoisomerase, an enzyme thatcontrols and alters the topologic states of DNA during transcription. Thisnuclear enzyme is involved in processes such as chromosome condensation,chromatid separation, and the relief of torsional stress that occurs duringDNA transcription and replication. It catalyzes the transient breaking andrejoining of two strands of duplex DNA which allows the strands to passthrough one another, thus altering the topology of DNA. Two forms of thisenzyme exist as likely products of a gene duplication event. The geneencoding this form, alpha, is localized to chromosome 17 and the beta gene islocalized to chromosome 3. The gene encoding this enzyme functions as thetarget for several anticancer agents and a variety of mutations in this genehave been associated with the development of drug resistance. Reducedactivity of this enzyme may also play a role in ataxia-telangiectasia. |
| Applications: | ELISA; WB |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Molecular Weight: | 36.41kDa |
| Species: | Human |
| Tag: | GST |
| Expression System: | Wheat germ |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Gene Name: | TOP2A topoisomerase (DNA)II alpha 170kDa [ Homo sapiens ] |
| Gene ID NCBI: | 7153 |
| Synonyms: | TOP2A; topoisomerase (DNA) II alpha 170kDa; TOP2;TP2A; DNA topoisomerase 2-alpha; DNA gyrase; DNA topoisomerase II, 170 kD; DNAtopoisomerase (ATP-hydrolyzing); DNA topoisomerase II, alpha isozyme; OTTHUMP00000207108;EC 5.99.1.3 |
| mRNA Refseq: | NM_001067 |
| Protein Refseq: | NP_001058 |
| MIM: | 126430 |
| UniProt ID: | P11388 |
| Chromosome Location: | 17q21-q22 |
| Function: | ATP binding; enzymebinding; DNAtopoisomerase (ATP-hydrolyzing) activity |
| Product Types | ||
| ◆ Proteins & Enzymes | ||
| PE-0587 | Recombinant Human TOP2A, GST-tagged | Inquiry |
| PE-0588 | Recombinant Human TOP2A | Inquiry |
| PE-0589 | Recombinant Human TOP2A, GST-tagged | Inquiry |
| PE-0590 | Recombinant Chicken TOP2A | Inquiry |
| PE-0591 | Recombinant Zebrafish TOP2A | Inquiry |
| Related Gene / Proteins | |||
| TOP2A | TORC2 | TOX1 | TOX3 |
| TOX4 | |||
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