| Cat.No.: | PE-0595 |
| Product Name: | Recombinant Human TOP2A protein, His & T7-tagged |
| Product Overview: | Recombinant Human TOP2A aa. (Ile923~Arg1148 (Accession # P11388)) fused with N-terminal His & T7 tag was produced in E. coli cells. |
| Description: | This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. |
| Applications: | SDS-PAGE; WB; ELISA; IP. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Appearance: | Freeze-dried powder |
| Molecular Weight: | Predicted Molecular Mass: 30.3kDa |
| Purity: | >95% |
| Species: | Human |
| Tag: | His & T7 |
| Endotoxin: | <1.0EU per 1µg (determined by the LAL method) |
| Reconstitution: | Reconstitute in sterile ddH2O. |
| Expression System: | E. coli |
| Isoelectric Point: | The isoelectric point is 6.2. |
| Protein Length: | Ile923~Arg1148 (Accession # P11388) |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Gene Name: | TOP2A topoisomerase (DNA) II alpha [ Homo sapiens (human) ] |
| Gene ID NCBI: | 7153 |
| Official Symbol: | TOP2A |
| Synonyms: | TOP2; TP2A; DNA gyrase; DNA topoisomerase (ATP-hydrolyzing); DNA topoisomerase II, 170 kD; DNA topoisomerase II, alpha isozyme; topoisomerase (DNA) II alpha 170kDa; DNA topoisomerase 2-alpha |
| mRNA Refseq: | NM_001067.3 |
| Protein Refseq: | NP_001058.2 |
| UniProt ID: | P11388 |
| Product Types | ||
| ◆ Proteins & Enzymes | ||
| PE-0587 | Recombinant Human TOP2A, GST-tagged | Inquiry |
| PE-0588 | Recombinant Human TOP2A | Inquiry |
| PE-0589 | Recombinant Human TOP2A, GST-tagged | Inquiry |
| PE-0590 | Recombinant Chicken TOP2A | Inquiry |
| PE-0591 | Recombinant Zebrafish TOP2A | Inquiry |
| Related Gene / Proteins | |||
| TOP2A | TORC2 | TOX1 | TOX3 |
| TOX4 | |||
USA
Enter your email here to subscribe.
Follow us on
Easy access to products and services you need from our library via powerful searching tools
