| Cat.No.: | PE-1082 |
| Product Name: | Recombinant Human DOT1L |
| Product Overview: | Recombinant fragment, corresponding to amino acids 2-416 of Human KMT4 / Dot1L with N terminal proprietary tag, 73 kDa. |
| Description: | The protein encoded by this gene is a histone methyltransferase that methylates lysine-79 of histone H3. It is inactive against free core histones, but shows significant histone methyltransferase activity against nucleosomes. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Appearance: | Liquid |
| Species: | Human |
| Expression System: | E. coli |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Gene Name: | DOT1L DOT1-like, histone H3 methyltransferase (S. cerevisiae) [ Homo sapiens ] |
| Gene ID NCBI: | 84444 |
| Official Symbol: | DOT1L |
| Synonyms: | DOT1L; DOT1-like, histone H3 methyltransferase (S. cerevisiae); histone-lysine N-methyltransferase, H3 lysine-79 specific; DOT1; histone methyltransferase DOT1L; KIAA1814; KMT4; |
| mRNA Refseq: | NM_032482 |
| Protein Refseq: | NP_115871 |
| MIM: | 607375 |
| UniProt ID: | Q8TEK3 |
| Chromosome Location: | 19p13.3 |
| Function: | DNA binding; histone-lysine N-methyltransferase activity; methyltransferase activity; protein binding; transferase activity; |
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