The nucleosome is a complex composed of DNA and four pairs of histones (eight in total), including two groups of H2A and H2B dimers and two groups of H3 and H4 dimers. And the H1 is responsible for linking DNA between two nucleosomes.

At Creative BioMart, we offer a variety of native and recombinant nucleosomes. Whether it is with or without post-translational modifications (PTMs), or with histone variants, or with methylated DNA, you can find it here. We also can custom-produce according to your exact request if your target is not in our catalog. Our nucleosome products are suitable for use in enzyme kinetic studies, inhibitor screening, structural studies or as substrates for effector protein binding experiments and so on.

Advantages of Our Nucleosomes:

1. Reliable quality & Broad source: High-quality native nucleosomes purified from eukaryotic nuclei or ultra-pure recombinant nucleosomes assembled in vitro.
2. Extensive applications: Our nucleosome is an important tool for your in vitro chromatin assembly, the optimal choice for your epigenetic modifying enzyme assay and small-molecule inhibitor screening, and the ideal substrate to study structural changes induced by the histone variants and histone mutations.
3. Cost-effective: Creative BioMart saves you precious time and effort by providing pre-assembled nucleosomes with competitive prices.