| Cat.No.: | PE-0713 |
| Product Name: | Recombinant Human Geminin, DNA Replication Inhibitor, His-tagged |
| Product Overview: | Recombinant human GMNN protein expressed in E.coli, 27.6kDa (245aa). |
| Description: | Recombinant human, Geminin is a 25 kDa protein, which inhibits DNA replication and is degraded during the mitotic phase of the cell cycle. Geminin controls replication by binding to the licensing factor Cdt1, and is involved in neural differentiation. In addition, geminin directly interacts with Six3 and Hox homeodomain proteins during embryogenesis and inhibits their functions. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Purity: | > 95% by SDS - PAGE. |
| Species: | Human |
| Formulation: | Liquid. In 20 mM Tris-HCl buffer (pH 7.5) containing 100 mM NaCl, 5 mM DTT, 20% glycerol. |
| Tag: | His |
| Amino Acid Sequence: | MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSMNPS MKQK QE EIK E NIKNSSVPRR TLKMIQPSAS GSLVGRENEL SAGLSKRKHR NDHLTS T TSS PGVIVPESSE NKNLGGVTQE SFDLMIKENP SSQYWKEVAE KRRKALY EAL KENEKLHKEI EQKDNEIARL KKENKELAEV AEHVQYMAEL IERLNGEP LD NFESLDNQEF DSEEETVEDS LVEDSEIGTC AEGTVSSSTD AKPCI |
| Expression System: | E. coli |
| Concentrations: | 1 mg/ml (determined by Bradford assay) |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Gene Name: | GMNN geminin, DNA replication inhibitor [ Homo sapiens ] |
| Gene ID NCBI: | 51053 |
| Synonyms: | GMNN; Gem; RP3-369A17.3; geminin; OTTHUMP00000039393; geminin, DNA replication inhibitor. |
| mRNA Refseq: | NM_015895 |
| Protein Refseq: | NP_056979 |
| MIM: | 602842 |
| Chromosome Location: | 6p22.3 |
| Function: | protein binding |
| Product Types | ||
| ◆ Extracts & Lysates | ||
| EL-0088 | Recombinant Human GMNN 293 Cell Lysate | Inquiry |
| ◆ Proteins & Enzymes | ||
| PE-0713 | Recombinant Human Geminin, DNA Replication Inhibitor, His-tagged | Inquiry |
| PE-0714 | Recombinant Human GMNN protein, His-tagged | Inquiry |
| PE-0715 | Recombinant Human GMNN, His-tagged | Inquiry |
| PE-0716 | Recombinant Human GMNN, GST-tagged | Inquiry |
| Related Gene / Proteins | |||
| GMNN | |||
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