| Cat.No.: | PE-0715 |
| Product Name: | Recombinant Human GMNN, His-tagged |
| Product Overview: | Recombinant full length protein: Human Geminin fused to His-Tag at N-terminus. |
| Description: | This gene encodes a protein that plays a critical role in cell cycle regulation. The encoded protein inhibits DNA replication by binding to DNA replication factor Cdt1, preventing the incorporation of minichromosome maintenance proteins into the pre-replication complex. The encoded protein is expressed during the S and G2 phases of the cell cycle and is degraded by the anaphase-promoting complex during the metaphase-anaphase transition. Increased expression of this gene may play a role in several malignancies including colon, rectal and breast cancer. Alternatively spliced transcript variants have been observed for this gene, and two pseudogenes of this gene are located on the short arm of chromosome 16. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Appearance: | Liquid |
| Purity: | >95% by SDS-PAGE |
| Species: | Human |
| Tag: | His |
| Sequence Similarities: | Belongs to the geminin family. |
| Expression System: | E. coli |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Gene Name: | GMNN geminin, DNA replication inhibitor [ Homo sapiens ] |
| Gene ID NCBI: | 51053 |
| Official Symbol: | GMNN |
| Synonyms: | GMNN; geminin, DNA replication inhibitor; geminin; Gem; |
| mRNA Refseq: | NM_001251989 |
| Protein Refseq: | NP_001238918 |
| MIM: | 602842 |
| UniProt ID: | O75496 |
| Chromosome Location: | 6p21.32 |
| Function: | histone deacetylase binding; protein binding; repressing transcription factor binding; |
| Product Types | ||
| ◆ Extracts & Lysates | ||
| EL-0088 | Recombinant Human GMNN 293 Cell Lysate | Inquiry |
| ◆ Proteins & Enzymes | ||
| PE-0713 | Recombinant Human Geminin, DNA Replication Inhibitor, His-tagged | Inquiry |
| PE-0714 | Recombinant Human GMNN protein, His-tagged | Inquiry |
| PE-0715 | Recombinant Human GMNN, His-tagged | Inquiry |
| PE-0716 | Recombinant Human GMNN, GST-tagged | Inquiry |
| Related Gene / Proteins | |||
| GMNN | |||
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