| Cat.No.: | PE-0753 |
| Product Name: | Recombinant Human KPNA2, T7 -tagged |
| Product Overview: | Recombinant full length protein (Human).(T7 tag at N-terminus). |
| Description: | The import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear envelope and the second is an energy-dependent translocation through the nuclear pore complex. Imported proteins require a nuclear localization sequence (NLS) which generally consists of a short region of basic amino acids or 2 such regions spaced about 10 amino acids apart. Proteins involved in the first step of nuclear import have been identified in different systems. These include the Xenopus protein importin and its yeast homolog, SRP1 (a suppressor of certain temperature-sensitive mutations of RNA polymerase I in Saccharomyces cerevisiae), which bind to the NLS. KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. |
| Tissue Specificity: | Expressed ubiquitously. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Appearance: | Liquid |
| Purity: | >95% by SDS-PAGE |
| Species: | Human |
| Tag: | T7 |
| Sequence Similarities: | Belongs to the importin alpha family.Contains 10 ARM repeats.Contains 1 IBB domain. |
| Expression System: | E. coli |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Gene Name: | KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) [ Homo sapiens ] |
| Gene ID NCBI: | 3838 |
| Official Symbol: | KPNA2 |
| Synonyms: | KPNA2; karyopherin alpha 2 (RAG cohort 1, importin alpha 1); RCH1; importin subunit alpha-2; IPOA1; QIP2; SRP1alpha; |
| mRNA Refseq: | NM_002266 |
| Protein Refseq: | NP_002257 |
| MIM: | 600685 |
| UniProt ID: | P52292 |
| Chromosome Location: | 17q24.2 |
| Function: | histone deacetylase binding; nuclear localization sequence binding; protein binding; protein transporter activity; |
| Product Types | ||
| ◆ Extracts & Lysates | ||
| EL-0094 | Recombinant Human KPNA2 293 Cell Lysate | Inquiry |
| ◆ Proteins & Enzymes | ||
| PE-0751 | Recombinant Human KPNA2, His-tagged | Inquiry |
| PE-0752 | Recombinant Human KPNA2, T7-tagged | Inquiry |
| PE-0753 | Recombinant Human KPNA2, T7 -tagged | Inquiry |
| PE-0754 | Recombinant Human Karyopherin Alpha 2 (RAG cohort 1, importin alpha 1), His-tagged | Inquiry |
| Related Gene / Proteins | |||
| KPNA2 | |||
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