| Cat.No.: | PE-0754 |
| Product Name: | Recombinant Human Karyopherin Alpha 2 (RAG cohort 1, importin alpha 1), His-tagged |
| Product Overview: | Recombinant humanKPNA2 protein, fused to His-tag at N-terminus, was expressed in E. coli andpurified by using conventional chromatography. |
| Description: | Karyopherinalpha2 (KPNA2) is a member of the karyopherin alpha family. This proteinplays a key role in the nuclear import of proteins with a classical nuclearlocalization signal (NLS). KPNA2 bound in vitro specifically and directly tosubstrates containing either a simple or bipartite NLS motif. It promoteddocking of import substrates to the nuclear envelope and together withrecombinant human Ran reconstituted complete nuclear protein import. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Molecular Weight: | 60.5 kDa(553aa) |
| Purity: | > 90%by SDS - PAGE |
| Species: | Human |
| Formulation: | Liquid. 20mMTris-HCl buffer (pH8.0) containing 20% glycerol, 1mM DTT. |
| Tag: | His |
| Amino Acid Sequence: | MGSSHHHHHHSSGLVPRGSH MGSHMSTNEN ANTPAARLHR FKNKGKDSTE MRRRRIEVNV ELRKAKKDDQMLKRRNVSSF PDDATSPLQE NRNNQGTVNW SVDDIVKGIN SSNVENQLQA TQAARKLLSR EKQPPIDNIIRAGLIPKFVS FLGRTDCSPI QFESAWALTN IASGTSEQTK VVVDGGAIPA FISLLASPHA HISEQAVWALGNIAGDGSVF RDLVIKYGAV DPLLALLAVP DMSSLACGYL RNLTWTLSNL CRNKNPAPPI DAVEQILPTLVRLLHHDDPE VLADTCWAIS YLTDGPNERI GMVVKTGVVP QLVKLLGASE LPIVTPALRA IGNIVTGTDEQTQVVIDAGA LAVFPSLLTN PKTNIQKEAT WTMSNITAGR QDQIQQVVNH GLVPFLVSVL SKADFKTQKEAVWAVTNYTS GGTVEQIVYL VHCGIIEPLM NLLTAKDTKI ILVILDAISN IFQAAENLGE TEKLSIMIEECGGLDKIEAL QNHENESVYK ASLSLIEKYF SVEEEEDQNV VPETTSEGYT FQVQDGAPGT FNF |
| Expression System: | E. coli |
| Concentrations: | 1 mg/ml(determined by Bradford assay) |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Gene Name: | KPNA2 karyopherin alpha 2 (RAGcohort 1, importin alpha 1) [ Homo sapiens ] |
| Gene ID NCBI: | 3838 |
| Official Symbol: | KPNA2 |
| Synonyms: | KPNA2; karyopherin alpha 2 (RAG cohort 1,importin alpha 1); QIP2; RCH1; IPOA1; SRP1alpha; importin subunit alpha-2;pendulin; SRP1-alpha; RAG cohort 1; importin alpha 1; importin alpha 2;importin-alpha-P1; RAG cohort protein 1; karyopherin subunit alpha-2 |
| mRNA Refseq: | NM_002266 |
| Protein Refseq: | NP_002257 |
| MIM: | 600685 |
| UniProt ID: | P52292 |
| Chromosome Location: | 17q24.2 |
| Function: | histone deacetylase binding; nuclearlocalization sequence binding; protein binding; protein transporter activity |
| Product Types | ||
| ◆ Extracts & Lysates | ||
| EL-0094 | Recombinant Human KPNA2 293 Cell Lysate | Inquiry |
| ◆ Proteins & Enzymes | ||
| PE-0751 | Recombinant Human KPNA2, His-tagged | Inquiry |
| PE-0752 | Recombinant Human KPNA2, T7-tagged | Inquiry |
| PE-0753 | Recombinant Human KPNA2, T7 -tagged | Inquiry |
| PE-0754 | Recombinant Human Karyopherin Alpha 2 (RAG cohort 1, importin alpha 1), His-tagged | Inquiry |
| Related Gene / Proteins | |||
| KPNA2 | |||
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