agpat6
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  • Official Full Name
  • 1-acylglycerol-3-phosphate O-acyltransferase 6
  • Background
  • Lysophosphatidic acid acyltransferases (EC 2.3.1.51) catalyze the conversion of lysophosphatidic acid (LPA) to phosphatidic acid (PA). LPA and PA are involved in signal transduction and lipid biosynthesis.[supplied by OMIM, Apr 2004]
  • Synonyms
  • AGPAT6; 1-acylglycerol-3-phosphate O-acyltransferase 6; LPAATZ; TSARG7; 1-AGPAT 6; LPAAT-zeta; glycerol-3-phosphate acyltransferase 6; 1-AGP acyltransferase 6; lysophosphatidic acid acyltransferase zeta; testis spermatogenesis apoptosis-related protein 7; 1-acyl-sn-glycerol-3-phosphate acyltransferase zeta; 1-acylglycerol-3-phosphate O-acyltransferase 6 (lysophosphatidic acid acyltransferase, zeta);
Cat.#:AGPAT6-435HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human AGPAT6 Protein, GST-tagged
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Cat.#:AGPAT6-9478HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human AGPAT6, GST-tagged
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Cat.#:AGPAT6-1421MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse AGPAT6 Protein
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Cat.#:AGPAT6-3735ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish AGPAT6
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Cat.#:AGPAT6-37HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human AGPAT6 cell lysate
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Involved Pathway

AGPAT6 involved in several pathways and played different roles in them. We selected most pathways AGPAT6 participated on our site, such as CDP-diacylglycerol biosynthesis, Fatty acid, triacylglycerol, and ketone body metabolism, Glycerolipid metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with AGPAT6 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
CDP-diacylglycerol biosynthesis
GPAT2; CDS1; GK5; AGPAT2; AGPAT1; AGPAT6
Fatty acid, triacylglycerol, and ketone body metabolism
SREBF2; MED21; AGT; MED20; MMAA; SIN3B; MED29; SLC25A1; MED18; ACOT9.1
Glycerolipid metabolism
AKR1A1B; CELL; PPAP2A; PPAP2C; AKR1B1L; LPIN2; PNPLA2; PPAP2D; PNLIPRP2; AKR1B7
Glycerophospholipid biosynthesis
PLBD1; PITPNB; AGPAT6; PLD6; PHOSPHO1; AWAT2; PEMT; CEPT1A; PNPLA8; STIL
Glycerophospholipid metabolism
GPCPD1; PLA2G2F; PLA2G3; PNPLA7; LPIN3; LPIN1; TAZ; AGXT2L1; PPAP2CB; PLA2G4A
Metabolic pathways
PGAM1B; COQ5; ALDH18A1; CSGALNACT2; GCLC; NDUFS6; PLA2G2A; PYCR1B; CERS5; POLD2
Metabolism
HSD17B11; SLC25A1; CPTP; SLC26A1; DIO2; GYG1B; CTGF; NUDT4; Gpc2; SLCO1B1
Metabolism of lipids and lipoproteins
COQ7; SLC25A1; FAAH2; ACAD11; GLTPD1; ALOX5AP; CHAT; GLIPR1; TIAM2; TPTE

Protein Function

AGPAT6 has several biochemical functions, for example, NOT 1-acylglycerol-3-phosphate O-acyltransferase activity, glycerol-3-phosphate O-acyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by AGPAT6 itself. We selected most functions AGPAT6 had, and list some proteins which have the same functions with AGPAT6. You can find most of the proteins on our site.
Function
Related Protein
Function NOT 1-acylglycerol-3-phosphate O-acyltransferase activity
Related Protein AGPAT6
Function glycerol-3-phosphate O-acyltransferase activity
Related Protein AGPAT9; GPAM; AGPAT9L; GPAT2; AGPAT6

Interacting Protein

AGPAT6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AGPAT6 here. Most of them are supplied by our site. Hope this information will be useful for your research of AGPAT6.
HSD17B7; 1C

AGPAT6 Related Articles

Bunel, A; Jorssen, EP; et al. Individual bovine in vitro embryo production and cumulus cell transcriptomic analysis to distinguish cumulus-oocyte complexes with high or low developmental potential. THERIOGENOLOGY 83:228-237(2015).
Sankella, S; Garg, A; et al. Hepatic Gluconeogenesis Is Enhanced by Phosphatidic Acid Which Remains Uninhibited by Insulin in Lipodystrophic Agpat2 Mice*. JOURNAL OF BIOLOGICAL CHEMISTRY 289:4762-4777(2014).