SARS-CoV-2 Proteins and Their Target Proteins

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SARS-CoV-2 Proteins and Their Target Proteins

The COVID-19 outbreak has caused large numbers of death, as well as social and economic chaos worldwide. SARS-CoV-2 virus is the causative agent of this respiratory disease.

The scientific community has known that SARS-CoV-2 binds to host cell receptors through its surface spike (S) proteins and is endocytosed into cells through clathrin-mediated membrane fusion. The relationship and affinity between the host cell receptor and the virus surface protein determine the infectivity and cytophilic characteristics of the virus. The pathogenicity and invading of the virus are related to the type and function of the host cell. Crystal structure analysis confirmed that angiotensin-converting enzyme 2 (ACE2) is the receptor for SARS-CoV-2 S protein, and the affinity of the two is 10-20 times that of SARS-CoV and ACE2, which is the reason of SARS-CoV-2 super infectivity.

So far, no clinically available antiviral drugs have been developed for SARS-CoV, SARS-CoV-2, or MERS-CoV. Some studies used affinity purification-mass spectrometry analysis that have identified hundreds of protein interactions between SARS-CoV-2 proteins and human proteins, including DNA replication (Nsp1), epigenetic and gene expression regulators (Nsp5, Nsp8, Nsp13, E), vesicle trafficking (Nsp6, Nsp7, Nsp10, Nsp13, Nsp15, Orf3a, E, Orf8), lipid modification (Spike), RNA processing and regulation (Nsp8, N), ubiquitin ligases (Orf10), signaling (Nsp8, Nsp13, N, Orf9b), nuclear transport machinery (Nsp9, Nsp15, Orf6), cytoskeleton (Nsp1, Nsp13), mitochondria (Nsp4, Nsp8, Orf9c), and extracellular matrix (Nsp9). Results from data analysis suggested that the viral proteins connect to a wide array of biological processes, including protein trafficking, translation, transcription, and ubiquitination regulation.

A total of 332 high confidence SARS-CoV-2-human protein-protein interactions (PPIs) have been identified. Among these, using a combination of a systematic chemoinformatic drug search with a pathway centric analysis, researchers have uncovered 66 druggable human proteins or host factors targeted by close to 70 different drugs and compounds, including FDA approved drugs, compounds in clinical trials as well as preclinical compounds. Additionally, this proteomic/chemoinformatic analysis gives these potential therapeutic perturbations a mechanistic context.

Creative BioMart has collected many SARS-CoV-2 related proteins and druggable target proteins, which can help you discover antiviral therapies against SARS-CoV-2 and other deadly coronavirus strains.

For more protein product information or custom protein expression service, please feel free to contact us.

Featured Interaction Proteins

Cat.No.  Product Name Identity Species Source
ACE2-736H Recombinant Human ACE2, His-tagged ACE2-His Human HEK293
ACE2-68H Recombinant Human ACE2, Fc-tagged ACE2-hFc Human HEK293
ACE2-185H Recombinant Human ACE2, mouse IgG1 Fc-tagged ACE2-mFc Human HEK293
TMPRSS2-1856H Recombinant Human TMPRSS2 Protein (106-492 aa), His-tagged TMPRSS2-His Human Yeast
TMPRSS2-4899H Recombinant Human TMPRSS2, his-tagged TMPRSS2-His Human HEK293
ACE2-229H Recombinant Human ACE2 protein, His/Avi-tagged ACE2-His/Avi Human Mammalian cells

Druggable Targets

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