Experiment Consulting and Design Service

Creative BioMart offers a professional Experiment Consulting and Design Service aimed at supporting researchers in developing precise, efficient, and reproducible experimental strategies. Recognizing that high-quality experimental design is the cornerstone of successful scientific research, we provide customized support across various domains, including custom protein production, biopharmaceutical development, and protein profiling. With a team of experienced scientists, advanced technologies, and a customer-oriented approach, Creative BioMart transforms your research concepts into well-structured experiments—maximizing both scientific rigor and project efficiency.

Background: Why Strategic Experimental Design is Crucial in Protein Research

A carefully constructed experimental design is fundamental to the integrity and reproducibility of any scientific investigation. From the initial concept to data analysis, each stage of a research project is directly influenced by the underlying design strategy. The selection of experimental systems, methodologies, and protocols can significantly impact the quality, reliability, and interpretability of results.

At Creative BioMart, we recognize that scientific innovation depends on the ability to identify core research objectives and apply the most appropriate and effective methodologies to achieve them. Our extensive experience in protein science and life sciences research enables us to assist clients in making informed decisions about experimental approaches, thus improving success rates and research efficiency.

By maintaining close engagement with current scientific developments and leveraging state-of-the-art laboratory resources, Creative BioMart has consistently delivered high-quality experimental solutions for academic, biotech, and pharmaceutical clients worldwide. Our team is equipped to guide your project from idea to execution, providing insightful design, expert consultation, and ongoing technical support.

Custom Experimental Design and Consultation Services

Service Procedure

Service Details

Our consulting and design services cover (but are not limited to):

Custom Protein Services

Comprehensive design of protein expression, purification, and modification protocols.

Protein Analysis

Strategy development for quantification, stability testing, structural analysis, and interaction studies.

Protein Screening & Profiling

High-throughput and targeted designs for functional screening or biomarker discovery.

Biopharmaceutical Solutions

Experimental planning for preclinical assays, formulation testing, and bioactivity studies.

Food & Health Testing

Customized approaches for protein detection, allergen analysis, and bioactive component evaluation.

Benefits of Partnering with Us for Experiment Planning

Fully Customized Solutions: Each project is approached individually, with designs tailored specifically to the client’s research objectives, sample types, and budgetary considerations.

Experienced Scientific Team: Our team comprises specialists in protein science, molecular biology, and biotechnology, ensuring a high level of technical expertise in every consultation.

State-of-the-Art Technology: We apply the latest equipment, methodologies, and research tools to ensure modern, efficient, and scientifically sound experiment design.

Integrated One-Stop Support: From experimental planning to protein production and data analysis, Creative BioMart offers a comprehensive solution under one roof.

High Cost-Effectiveness: Our consultative approach reduces experimental redundancy and increases success rates, helping clients save time and resources.

Reliable Turnaround: We maintain a balance between timely delivery and scientific accuracy, enabling clients to meet critical research milestones.

Case Studies–Real-World Research Projects

* NOTE: We prioritize confidentiality to safeguard our clients’ technology and intellectual property. As an alternative, we present selected published research articles as representative case studies. For details on the assay services and products used in these studies, please refer to the relevant sections of the cited literature.

Case 1: Target-agnostic discovery of membrane receptor targets via phenotypic screening and thermal proteome profiling

Carnero Corrales et al., 2021. doi:10.1016/j.chembiol.2021.02.017

This study used a multi-tiered experimental design to identify membrane-bound protein targets of small molecules, focusing on autophagy inhibition. A high-content phenotypic screen in MCF7-eGFP-LC3 cells first identified indophagolin as a potent autophagy inhibitor. Thermal proteome profiling (TPP) and cellular thermal shift assays (CETSA) were employed to identify P2X4 as a membrane-bound target, validated by western blot and isothermal dose-response. Nano-LC-MS/MS with TMT labeling enabled proteomic quantification. Complementary assays, including immunoblotting, confocal microscopy, and calcium flux in P2X/P2Y-expressing cells, confirmed functional inhibition. The workflow demonstrates a target-agnostic approach for de novo identification of membrane receptor targets of bioactive compounds.

Figure 1. Study overview. (Carnero Corrales et al., 2021)

Case 2: Rapid protein quantification in oilseeds via modified whole-grain Kjeldahl method

Langyan et al., 2022. doi:10.3389/fnut.2022.892695

This study presents a modified Kjeldahl method for rapid and efficient protein quantification in oilseed crops, aiming to overcome limitations of traditional sample preparation. Instead of grinding oilseeds into fine flour—a time-consuming step prone to cross-contamination and oil loss—the method directly digests whole grains. A modified digestion mixture was also introduced to reduce frothing and shorten digestion time. The new approach was statistically validated (ANOVA, t-tests, Pearson correlation), showing no significant difference in protein content between whole grain and flour preparations across five oilseed types. This streamlined method enhances speed and reliability in protein analysis.

Figure 2. The modified sample preparation method with digestion mixture for protein analysis using Kejdhal method. (Langyan et al., 2022)

Researcher Feedback on Our Experimental Design Services

“We were struggling to optimize an expression system for a membrane-bound receptor protein involved in cancer signaling. Creative BioMart’s experiment design team helped us evaluate multiple constructs and suggested a mammalian expression platform with codon optimization. Their detailed experimental roadmap reduced our development time by at least a month and produced reproducible results across replicates. It was a game-changer for our screening assays.”

— Principal Investigator | Oncology Research Institute

“We needed to develop a reliable ELISA assay for quantifying a novel fusion protein in human plasma. Creative BioMart not only advised us on the best antigen preparation strategy but also designed a custom protein purification protocol that preserved the protein’s immunogenic epitopes. Their consulting service gave us a robust, high-sensitivity assay that passed internal validation on the first run.”

— R&D Manager | Biotech CRO

“For our nutraceutical formulation, we were tasked with screening plant-derived proteins for anti-inflammatory activity. Creative BioMart guided us through a customized screening workflow—from extraction to in vitro bioassays. Their deep knowledge of protein science and practical approach allowed us to identify two promising candidates ahead of schedule. Their input helped us save weeks of internal testing.”

— Senior Scientist | Functional Food Company

“We had a challenging protein aggregation issue during scale-up of a therapeutic enzyme. Creative BioMart conducted a comprehensive review of our protocol and redesigned our buffer system and purification steps. They also recommended an alternative refolding strategy that significantly improved solubility and activity. Their consulting support was instrumental in preparing our protein for preclinical testing.”

— Director of Protein Engineering | Biopharmaceutical Company

Frequently Asked Questions on Experiment Consulting and Design

• Q: What types of research projects do you support through your experiment consulting and design service?

  A: We support a broad range of life science research projects, including custom protein expression, protein analysis, biopharmaceutical development, protein screening and profiling, and food and health testing. Each project is handled with a tailored approach to meet specific scientific goals and technical requirements.

• Q: How is your experimental design service customized to my project?

  A: Our team collaborates closely with you to understand your research objectives, system preferences, and constraints. We then develop a customized experimental strategy—including method selection, control design, and protocol optimization—based on current technologies and best practices in your specific research area.

• Q: Do I need to have a complete project plan before reaching out?

  A: Not at all. You can contact us with just a basic research concept or question, and our scientific experts will help shape it into a fully developed and executable experimental design.

• Q: What makes your experiment consulting service different from others?

  A: We combine years of hands-on experience in protein science with cutting-edge experimental tools and a client-first mindset. Our solutions are fully customized, scientifically rigorous, and designed to deliver reproducible, high-quality results efficiently and cost-effectively.

• Q: Can I consult with your team during the execution of my experiments?

  A: Yes. Our service includes ongoing scientific support, allowing you to consult with our experts throughout your project to address troubleshooting, protocol adjustments, or optimization questions.

• Q: Do you offer support for scaling up experiments after initial design?

  A: Absolutely. We offer end-to-end support, including optimization for scale-up, transition to production, or preparation for regulatory studies in biopharmaceutical applications.

References:

1. Carnero Corrales MA, Zinken S, Konstantinidis G, et al . Thermal proteome profiling identifies the membrane-bound purinergic receptor P2X4 as a target of the autophagy inhibitor indophagolin. Cell Chemical Biology . 2021;28(12):1750-1757.e5. doi:10.1016/j.chembiol.2021.02.017
2. Langyan S, Bhardwaj R, Radhamani J, et al . A quick analysis method for protein quantification in oilseed crops: a comparison with standard protocol. Front Nutr . 2022;9:892695. doi:10.3389/fnut.2022.892695