Specially Designed Labeled Protein for Car-T Therapy

Specially Designed Labeled Protein for Car-T Therapy

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Specially Designed Labeled Protein for Car-T Therapy

For years, the foundations of cancer treatment were surgery, chemotherapy, and radiation therapy. But over the past several years, immunotherapy has emerged as what many in the cancer community now call the “fifth pillar” of cancer treatment.

CAR T-cell therapy is a type of immunotherapy that changes a patient’s own T cells so they are able to recognize and attack cancer. T cells are taken from a patient’s blood. Then the gene for a special receptor that binds to a certain protein on the patient’s cancer cells is added in the laboratory. 

One most import step of CAR-T cell therapy is T cell reengineering, which produce chimeric antigen receptors (CARs) on the surface of the cells. Then these reengineered T cell need to select and collected from others. This is often done by flow cytometry, using protein L, anti-Fab antibodies or target antigens as detection methods. Among these common choices, target antigens are widely considered to be the best option, because it offers high specificity and minimal background staining.

In order to avoid damage to healthy tissues caused by CAR-T cell therapy, the targets must be restricted to tumor cells. However, it is quite difficult to discover an ideal biomarker as an anti-tumor target, which highly expressed on tumor cell surface and rarely expressed on the healthy cell. In a more common situation, the chosen biomarkers express on both tumor cell and healthy ones, with a significant expression level discrimination.

Creative BioMart offers a variety of pre-fluorescent-conjugated and pre-biotinylated recombinant proteins, which are convenient for your cell separation. Featured products are listed below, please contact us for more details or more protein information. We could conjugate specific recombinant proteins according to your custom requirements.

Gene Cat.No. Products Name Source Species Tag
CD19 CD19-558H Recombinant Human CD19, His-tagged, Biotinylated Human Cell Human His
CD19-280H Recombinant Human CD19, Fc-tagged, Biotinylated HEK293 Human Fc
CD19-12H Recombinant Human CD19 protein, Fc-tagged, biotinylated HEK293 Human Fc
CD22 CD22-334H Recombinant Human CD22 Protein, Fc & Avi-tagged, Biotinylated HEK293 Human Avi|Fc
CD22-532H Recombinant Human CD22 Protein (Trp176-Arg687), His-tagged, Biotinylated Insect Cell Human His
CD22-560H Recombinant Human CD22, Fc-tagged, Biotinylated Human Cell Human Fc
CD22-559H Recombinant Human CD22, His-tagged, Biotinylated Human Cell Human His
CD274 CD274-1283H Recombinant Human CD274 protein, Avi & His-tagged, Biotinylated HEK293 Human Avi|His
CD274-1285M Recombinant Mouse CD274 protein, Avi & Fc-tagged, Biotinylated HEK293 Mouse Avi|Fc
CD274-1284H Recombinant Human CD274 protein, Avi & Fc-tagged, Biotinylated HEK293 Human Avi|Fc
CD274-365H Recombinant Human CD274 Protein, His & Fc & Avi-tagged, Biotinylated HEK293 Human His|Fc|Avi
CD274-339H Recombinant Human CD274 Protein (Met1-Thr239), HIgG1 Fc-tagged, Biotinylated HEK293 Human HIgG1 Fc
Cd274-721M Recombinant Mouse Cd274, Fc-tagged, Biotinylated Human Cell Mouse Fc
CD274-785H Recombinant Human CD274 protein, His-tagged, biotinylated HEK293 Human His
CD274-785M Recombinant Mouse CD274 Protein (Met1-Thr238), His-tagged, Biotinylated HEK293 Mouse His
CD274-8229H Recombinant Human CD274, Biotin-His-tagged HEK293 Human Biotin|His
CD274-8230H Recombinant Human CD274 protein, His/Fc-tagged, Biotinylated HEK293 Human His|Fc
CD274-256H Recombinant Human CD274, His-tagged, Biotinylated HEK293 Human His
Gene Cat.No. Products Name Source Species Tag
CD276 CD276-1286H Recombinant Human CD276 protein, Avi & His-tagged, Biotinylated HEK293 Human Avi|His
CD276-1287H Recombinant Human CD276 Protein, Fc-Avi-tagged, Biotinylated HEK293 Human Avi|Fc
CD276-502H Recombinant Human CD276 Protein (ECD) (Met1-Thr461), HIgG1 Fc-tagged, Biotinylated HEK293 Human HIgG1 Fc
CD276-543H Recombinant Human CD276, Fc-tagged, Biotinylated Human Cell Human Fc
CD276-4893H Recombinant Human CD276 protein, His-tagged, biotinylated HEK293 Human His
CD33 CD33-1081C Recombinant Cynomolgus CD33 Protein (Met1-Gly248), His-tagged, Biotinylated HEK293 Cynomolgus His
CD33-675H Recombinant Human CD33, Fc-tagged, Biotinylated Human Cell Human Fc
CD33-268H Recombinant Human CD33 Protein, His & Avi-tagged, Biotinylated HEK293 Human His|Avi
CD38 CD38-443H Recombinant Human CD38 Protein (Va43-Ile300), His-tagged, Biotinylated HEK293 Human His
CD38-573H Recombinant Human CD38, Fc-tagged, Biotinylated Human Cell Human Fc
CD38-1822H Recombinant Human CD38 protein, His & Avi-tagged, Biotinylated HEK293 Human His|Avi
Gene Cat.No. Products Name Source Species Tag
CD44 CD44-578H Recombinant Human CD44, Fc-tagged, Biotinylated Human Cell Human Fc
CD70 CD70-892H Recombinant Human CD70 Protein, Fc-Avi-tagged, Biotinylated HEK293 Human Avi|Fc
EGFR EGFR-288H Recombinant Human EGFR Protein, His-Avi-tagged, Biotinylated HEK293 Human His|Avi
EGFR-341H Recombinant Human EGFRvIII Protein, His & Avi-tagged, Biotinylated HEK293 Human His|Avi
EGFR-285H Recombinant Human EGFR, His&Avi-tagged, Biotinylated HEK293 Human His|Avi
EGFR-43H Recombinant Human EGFR(T790M/L858R) protein, Flag-tagged, Biotinylated Insect Cell Human Flag
EGFR-284H Recombinant Human EGFR, His-tagged, Biotinylated HEK293 Human His
EGFR-602H Recombinant Human EGFR, Fc-tagged, Biotinylated Human Cell Human Fc
EGFR-42H Recombinant Human EGFR protein, Flag-tagged, Biotinylated Insect Cell Human Flag
EGFR-287H Recombinant Human EGFR protein, Avi/His-tagged, Biotinylated HEK293 Human Avi|His
Gene Cat.No. Products Name Source Species Tag
CEACAM5 CEACAM5-495H Recombinant Human CEACAM5 Protein (Met1-Ala685), His-tagged, Biotinylated HEK293 Human His
EPCAM EPCAM-572H Recombinant Human EPCAM Protein, Fc-Avi-tagged, Biotinylated HEK293 Human Avi|Fc
EPCAM-350H Recombinant Human EPCAM Protein, His & Avi-tagged, Biotinylated HEK293 Human His|Avi
EPCAM-7818H Recombinant Human EPCAM Protein, Fc-Avi-tagged, Biotinylated HEK293 Human Avi|Fc
EPCAM-571H Recombinant Human EPCAM, Fc-tagged, Biotinylated Human Cell Human Fc
EPCAM-418H Recombinant Human EPCAM Protein (Met1-Lys265), HIgG1 Fc-tagged, Biotinylated Insect Cell Human HIgG1 Fc
EPCAM-276H Recombinant Human EPCAM, His-tagged, Biotinylated HEK293 Human His
Gene Cat.No. Products Name Source Species Tag
ERBB2 ERBB2-360H Recombinant Human ERBB2 Protein, His & Avi-tagged, Biotinylated HEK293 Human His|Avi
ERBB2-183H Recombinant Human ERBB2 Protein, His-Avi-tagged, Biotinylated HEK293 Human His|Avi
ERBB2-182H Recombinant Human ERBB2, His-tagged, Biotinylated HEK293 Human His
ERBB2-1110H Recombinant Human ERBB2 Protein (Met1-Thr652), HlgG1 Fc-tagged, Biotinylated HEK293 Human HlgG1 Fc
FOLR1 FOLR1-031H Recombinant Human FOLR1 Protein, His-Avi-tagged, Biotinylated HEK293 Human His|Avi
FOLR1-317M Recombinant Mouse FOLR1 Protein, His & Avi-tagged, Biotinylated HEK293 Mouse His|Avi
Folr1-0630M Recombinant Mouse Folr1 protein, His-tagged, Biotinylated HEK293 Mouse His
GPC3 GPC3-2247H Recombinant Human GPC3 Protein, His-Avi-tagged, Biotinylated HEK293 Human His|Avi
GPC3-619H Recombinant Human GPC3, Fc-tagged, Biotinylated Human Cell Human Fc
Gene Cat.No. Products Name Source Species Tag
IL1RAP IL1RAP-628H Recombinant Human IL1RAP, Fc-tagged, Biotinylated Human Cell Human Fc
KDR KDR-632H Recombinant Human KDR Protein, His-Avi-tagged, Biotinylated HEK293 Human His|Avi
KDR-630H Recombinant Human KDR, His-tagged, Biotinylated Human Cell Human His
KDR-631H Recombinant Human KDR, Fc-tagged, Biotinylated Human Cell Human Fc
KDR-6967H Recombinant Human KDR Protein, His & Avi-tagged, Biotinylated HEK293 Human His|Avi
KDR-58H Recombinant Human KDR protein, Flag-tagged, Biotinylated Insect Cell Human Flag
MET MET-195H Recombinant Human MET Protein, His & Avi-tagged, Biotinylated HEK293 Human His|Avi
MET-64H Recombinant Human MET protein, Flag-tagged, Biotinylated Insect Cell Human Flag
Gene Cat.No. Products Name Source Species Tag
MS4A1 MS4A1-470H Recombinant Human MS4A1 Protein (Ile141-Ser188), TrxA-tagged, Biotinylated E.coli Human TrxA
MS4A1-826H Recombinant Human MS4A1, Biotin-Fc-tagged HEK293 Human Biotin|Fc
MSLN MSLN-303H Recombinant Human MSLN Protein, His-Avi-tagged, Biotinylated HEK293 Human His|Avi
MSLN-304H Recombinant Human MSLN Protein, Fc-Avi-tagged, Biotinylated HEK293 Human Avi|Fc
MSLN-266H Recombinant Human MSLN Protein, His-tagged, Biotinylated HEK293 Cells Human His
MSLN-10623H Recombinant Human MSLN protein, His-tagged, Biotin Labeled. HEK293 Human His
MSLN-642H Recombinant Human MSLN, His-tagged, Biotinylated Human Cell Human His
MSLN-2967H Recombinant Human MSLN, Fc Tagged, Biotinylated Human Cell Human Fc
PDCD1 PDCD1-258H Recombinant Human PDCD1 Protein, Fc-Avi-His-tagged, Biotinylated HEK293 Human Avi|Fc|His
PDCD1-260H Recombinant Human PDCD1 Protein, Fc-Avi-tagged, Biotinylated HEK293 Human Avi|Fc
PDCD1-259H Recombinant Human PDCD1 Protein, His-Avi-tagged, Biotinylated HEK293 Human His|Avi
Pdcd1-206M Recombinant Mouse Pdcd1 Protein, Fc-Avi-tagged, Biotinylated HEK293 Mouse Avi|Fc
PDCD1-384H Recombinant Human PDCD1 Protein (Met1-Gln167), His-Fc-tagged, Biotinylated HEK293 Human His|Fc
PDCD1-1003C Recombinant Cynomolgus PDCD1 Protein (Met1-Gln167), AVI-Fc-tagged, Biotinylated HEK293 Cynomolgus Avi|Fc
PDCD1-370M Recombinant Mouse PDCD1 Protein, Fc & Avi-tagged, Biotinylated HEK293 Mouse Avi|Fc
Pdcd1-205M Recombinant Mouse Pdcd1, Fc tagged, Biotinylated HEK293 Mouse Fc
PDCD1-257H Recombinant Human PDCD1, His-tagged, Biotinylated HEK293 Human His
Gene Cat.No. Products Name Source Species Tag
ROR1 ROR1-1810H Recombinant Human ROR1 Protein, His-Avi-tagged, Biotinylated HEK293 Human His|Avi
ROR1-312H Recombinant Human ROR1 Protein (Gln 30 - Glu 403), Avi-tagged, Biotinylated HEK293 Human Avi
ROR1-595H Recombinant Human ROR1 Protein (Met1-Glu403), Biotinylated HEK293 Human N/A
ROR1-1811H Recombinant Human ROR1 protein, Fc & Avi-tagged, Biotinylated HEK293 Human Avi|Fc
ROR1-666H Recombinant Human ROR1, Fc-tagged, Biotinylated Human Cell Human Fc
SLAMF7 SLAMF7-187H Recombinant Human SLAMF7 Protein, His-Avi-tagged, Biotinylated HEK293 Human His|Avi
SLAMF7-688H Recombinant Human SLAMF7, Fc-tagged, Biotinylated Human Cell Human Fc
Gene Cat.No. Products Name Source Species Tag
TNFRSF17 Tnfrsf17-882M Recombinant Mouse TNFRSF17 Protein, Fc-Avi-tagged, Biotinylated HEK293 Mouse Avi|Fc
TNFRSF17-240H Recombinant Human TNFRSF17 Protein, His-Avi-tagged, Biotinylated HEK293 Human His|Avi
TNFRSF17-409H Recombinant Human TNFRSF17 Protein (Met1-Ala54), His-Fc-tagged, Biotinylated HEK293 Human His|Fc
TNFRSF17-984R Recombinant Rhesus TNFRSF17 Protein (Met1-Ala53), AVI-Fc-tagged, Biotinylated HEK293 Rhesus Avi|Fc
TNFRSF17-1827C Recombinant Cynomolgus TNFRSF17 protein, Fc & Avi-tagged, Biotinylated HEK293 Cynomolgus Avi|Fc
TNFRSF17-552H Recombinant Human TNFRSF17, Fc-tagged, Biotinylated Human Cell Human Fc
TNFRSF17-238H Recombinant Human TNFRSF17 Protein, Fc & Avi-tagged, Biotinylated HEK293 Human Avi|Fc
TNFRSF8 TNFRSF8-434H Recombinant Human TNFRSF8 Protein (Met1-Lys379), His-tagged, Biotinylated HEK293 Human His
TNFRSF8-1821H Recombinant Human TNFRSF8 protein, His & Avi-tagged, Biotinylated HEK293 Human His|Avi
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