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Official Full Name CD3d molecule, delta (CD3-TCR complex)
Background CD4 is a single chain transmembraneous glycoprotein (59 kDa) which belongs to the immunoglobulin superfamily. CD4 is present on a subset of T lymphocytes ("helper/inducer" T cells) and is also expressed at a lower level on monocytes, tissue macrophages and granulocytes. The antigen is involved in binding to MHC class II molecules. The intracellular domain of the antigen is associated with p56lck protein tyrosine kinase. T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits: CD3 gamma, CD3 delta, CD3 epsilon and CD3 zeta. These CD3 subunits are structurally related members of the immunoglobulins super family encoded by closely linked genes on human chromosome 11. The CD3 components have long cytoplasmic tails that associate with cytoplasmic signal transduction molecules. This association is mediated at least in part by a double tyrosine based motif present in a single copy in the CD3 subunits. CD3 may play a role in TCR induced growth arrest, cell survival and proliferation. The CD3 antigen is present on 68-82% of normal peripheral blood lymphocytes, 65-85% of thymocytes and Purkinje cells in the cerebellum. It is never expressed on B or NK cells. Decreased percentages of T lymphocytes may be observed in some autoimmune diseases.
Synonyms CD3D; CD3d molecule, delta (CD3-TCR complex); CD3d antigen, delta polypeptide (TiT3 complex) , T3D; T-cell surface glycoprotein CD3 delta chain; CD3 delta; OKT3, delta chain; CD3 antigen, delta subunit; T-cell receptor T3 delta chain; CD3d antigen, delta
    • Species :
    • Canine
    • Cattle
    • Chicken
    • Cynomolgus
    • Cynomolgus Monkey
    • Human
    • Mouse
    • Pig
    • Rat
    • Sheep
    • Source :
    • E.coli
    • HEK293
    • Human Cell
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • Fc
    • His
    • Flag
    • GST
    • S
    • His-Avi
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CD3D & CD3E-1714HCL Recombinant Human CD3D & CD3E cell lysate Human Cell N/A
    Human CD3D & CD3E-944HCL Recombinant Human CD3D & CD3E cell lysate Human Cell N/A
    Human CD3D-015H Recombinant Human CD3D protein, His-tagged HEK293 His
    Human CD3D-0799H Recombinant Human CD3D Protein Wheat Germ N/A
    Human CD3D-0800H Recombinant Human CD3D Protein, GST-Tagged Wheat Germ GST
    Human CD3D-10951H Recombinant Human CD3D, His-tagged E.coli His
    Human CD3D-1274HCL Recombinant Human CD3D cell lysate Human Cell N/A
    Human CD3D-163H Rcombinant Human CD3D, flag-tagged Human Cell Flag
    Human CD3D-1902H Recombinant Human CD3D protein, His & S-tagged E.coli His/S
    Human CD3D-2193H Recombinant Human CD3D, His tagged Human Cell His
    Human CD3D-464H Recombinant Human CD3D Protein (Met1-Ala105), Flag-Fc-tagged, Biotinylated HEK293 Flag/Fc
    Human CD3D-8542H Recombinant Human CD3D, Fc-His tagged Human Cell Fc/His
    Human CD3E & CD3D-375H Recombinant Human CD3E & CD3D protein, His & Flag-tagged, Biotinylated HEK293 His/Flag
    Human CD3E & CD3D-376H Recombinant Human CD3E & CD3D protein, His-tagged HEK293 His
    Human CD3E & CD3D-377H Recombinant Human CD3E & CD3D Protein, His-Avi-tagged, Biotinylated HEK293 His-Avi
    Human CD3E&CD3D-182H Recombinant Human CD3E&CD3D, His-Fc&Flag-Fc tagged HEK293 Flag/Fc/His
    Human CD3E&CD3D-219H Recombinant Human CD3E&CD3D, His&flag-tagged HEK293 His/Flag
    Mouse CD3D & CD3E-1076MCL Recombinant Mouse CD3D & CD3E cell lysate Human Cell N/A
    Mouse CD3D & CD3E-1726MCL Recombinant Mouse CD3D & CD3E cell lysate Human Cell N/A
    Mouse CD3D-1381MCL Recombinant Mouse CD3D cell lysate Human Cell N/A
    Mouse Cd3d-1903M Recombinant Mouse Cd3d protein, His-tagged E.coli His
    Mouse CD3D-865M Recombinant Mouse CD3D Protein, Fc-tagged HEK293 Fc
    Rat CD3D-1250R Recombinant Rat CD3D Protein Mammalian Cell His
    Rat Cd3d-1906R Recombinant Rat Cd3d protein, His-tagged E.coli His
    Cynomolgus Monkey CD3D & CD3E-1179CCL Recombinant Cynomolgus CD3D & CD3E cell lysate Human Cell N/A
    Cynomolgus Monkey CD3D-1182C Recombinant Cynomolgus CD3D Protein, Fc-tagged HEK293 Fc
    Cynomolgus CD3D-1183C Recombinant Cynomolgus CD3D protein, His-tagged HEK293 His
    Cynomolgus Monkey CD3D-1466CCL Recombinant Cynomolgus CD3D cell lysate Human Cell N/A
    Cynomolgus Monkey CD3D-389C Recombinant Cynomolgus CD3D Protein, His-tagged Mammalian Cell His
    Cynomolgus Monkey CD3E&CD3D-187C Recombinant Cynomolgus CD3E&CD3D, His & flag-tagged HEK293 His/Flag
    Cynomolgus Monkey CD3E&CD3D-209C Recombinant Cynomolgus CD3E&CD3D, His-Fc & flag-Fc-tagged HEK293 Flag/Fc/His
    Cynomolgus Monkey CD3E&CD3D-220C Recombinant Cynomolgus CD3E&CD3D, His-Fc&Flag-Fc tagged HEK293 Flag/Fc/His
    Cynomolgus Monkey CD3E-306C Recombinant Cynomolgus CD3D & CD3E, His-Fc & Flag-Fc tagged Human Cell Fc
    Canine CD3D-1056C Recombinant Canine CD3D Protein, Fc-tagged HEK293 Fc
    Chicken CD3D-7061C Recombinant Chicken CD3D Mammalian Cell His
    Cattle CD3D-1901C Recombinant Cattle CD3D protein, His & GST-tagged E.coli His/GST
    Sheep CD3D-1904S Recombinant Sheep CD3D protein, His-tagged E.coli His
    Pig CD3D-1905P Recombinant Pig CD3D protein, His-tagged E.coli His

    cd3d involved in several pathways and played different roles in them. We selected most pathways cd3d participated on our site, such as Hematopoietic cell lineage, T cell receptor signaling pathway, Chagas disease (American trypanosomiasis), which may be useful for your reference. Also, other proteins which involved in the same pathway with cd3d were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Hematopoietic cell lineage HLA-DRA; ITGAM; CD5; ITGA2B; CD22; ITGB3; CD3E; ITGA5; Fcer2a; GM-CSF
    T cell receptor signaling pathway PAK1; IKBKG; PPP3CC; OXSR1A; MAP2K7; Il2; SLA1; VAV3; CD4; SHB
    Chagas disease (American trypanosomiasis) NFKB1; MAPK12; PIK3CD; IKBKB; NFKBIA; FOS; PPP2R1A; MAPK10; MAPK13; IFNGR1
    HTLV-I infection WNT7B; ELK4; CD40; HLA-DQB1; HLA-C; ELK1; DVL3; IL6; HLA-DOA; APC2
    Primary i IL7R; TAP2; CD8B; RFX5; UNG; CD3E; CD79A; BLNK; RAG1; TNFRSF13B
    nodeficiency CD40LG; CD4; RFXANK; CD19; TAP1; CD8B; IL7R; BTK; BLNK; RFX5

    cd3d has several biochemical functions, for example, protein heterodimerization activity, transcription coactivator activity, transmembrane signaling receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by cd3d itself. We selected most functions cd3d had, and list some proteins which have the same functions with cd3d. You can find most of the proteins on our site.

    Function Related Protein
    protein heterodimerization activity TLR2; PVALB; SEPHS1; SPNA1; SUPT4H1; CENPA; NEFL; PDSS1; HIST1H2AL; NOTCH1
    transcription coactivator activity PMF1; HSF2; MMS19; HTATIP2; CDK7; GMEB2; SUPT3H; DDX17; NPAT; RXRA
    transmembrane signaling receptor activity EBP; NPR2; NPC1; CD5; EDAR; GHRHRA; TLR2-2; GHRHRL; SLAMF1; CLDN4

    cd3d has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with cd3d here. Most of them are supplied by our site. Hope this information will be useful for your research of cd3d.

    NR3C1; CANX; FYN; CD3E

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