CD3D

  • Official Full Name

    CD3d molecule, delta (CD3-TCR complex)

  • Overview

    CD4 is a single chain transmembraneous glycoprotein (59 kDa) which belongs to the immunoglobulin superfamily. CD4 is present on a subset of T lymphocytes ("helper/inducer" T cells) and is also expressed at a lower level on monocytes, tissue macrophages and granulocytes. The antigen is involved in binding to MHC class II molecules. The intracellular domain of the antigen is associated with p56lck protein tyrosine kinase. T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits: CD3 gamma, CD3 delta, CD3 epsilon and CD3 zeta. These CD3 subunits are structurally related members of the immunoglobulins super family encoded by closely linked genes on human chromosome 11. The CD3 components have long cytoplasmic tails that associate with cytoplasmic signal transduction molecules. This association is mediated at least in part by a double tyrosine based motif present in a single copy in the CD3 subunits. CD3 may play a role in TCR induced growth arrest, cell survival and proliferation. The CD3 antigen is present on 68-82% of normal peripheral blood lymphocytes, 65-85% of thymocytes and Purkinje cells in the cerebellum. It is never expressed on B or NK cells. Decreased percentages of T lymphocytes may be observed in some autoimmune diseases.
  • Synonyms

    CD3D; CD3d molecule, delta (CD3-TCR complex); CD3d antigen, delta polypeptide (TiT3 complex) , T3D; T-cell surface glycoprotein CD3 delta chain; CD3 delta; OKT3, delta chain; CD3 antigen, delta subunit; T-cell receptor T3 delta chain; CD3d antigen, delta;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Canine
  • Cattle
  • Chicken
  • Cynomolgus
  • Cynomolgus monkey
  • Cynomolgus Monkey
  • Dog
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Ovis aries (Sheep)
  • Pig
  • Rat
  • Rattus norvegicus (Rat)
  • Sheep
  • E.coli
  • E.coli expression system
  • HEK293
  • Human Cell
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • C
  • Fc
  • hFc
  • FLAG
  • His
  • Fc|His
  • Flag
  • Flag|Fc
  • Flag|Fc|His
  • GST
  • His (Fc)
  • Avi
  • flag
  • His|Flag
  • His|GST
  • His|S
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CD3E&CD3D-182H Active Recombinant Human CD3E&CD3D, His-Fc&Flag-Fc tagged HEK293 Flag/Fc/His
Human CD3E & CD3D-375H Active Recombinant Human CD3E & CD3D protein, His & Flag-tagged, Biotinylated HEK293 His & Flag Asp 23 - Asp 126 (CD3E) & Phe 22 - Ala 105 (CD3D)
Human CD3E & CD3D-376H Active Recombinant Human CD3E & CD3D protein, His-tagged HEK293 His Asp 23 - Asp 126 (CD3E) & Phe 22 - Ala 105 (CD3D)
Human CD3E & CD3D-377H Active Recombinant Human CD3E & CD3D Protein, His-Avi-tagged, Biotinylated HEK293 His-Avi Asp 23-Asp 126(CD3E) & Phe 22-Ala 105(CD3D)
Human CD3E&CD3D-219H Active Recombinant Human CD3E&CD3D, His&flag-tagged HEK293 His&flag Met1-Ala105&Met1-Asp126
Human CD3D-2193H Recombinant Human CD3D protein, His-tagged HEK293 His Met1-Ala105
Human CD3D-163H Rcombinant Human CD3D, flag-tagged Human Cell Flag
Human CD3D-015H Recombinant Human CD3D protein, His-tagged HEK293 His Phe22-Ala105
Human CD3D-0799H Recombinant Human CD3D Protein Wheat Germ N/A
Human CD3D-10951H Recombinant Human CD3D, His-tagged E.coli His 22-171a.a.
Human CD3D-0800H Recombinant Human CD3D Protein, GST-Tagged Wheat Germ GST
Human CD3D-8542H Recombinant Human CD3D, Fc-His tagged Human Cell Fc/His
Human CD3D-1902H Recombinant Human CD3D protein, His & S-tagged E.coli His/S Gln18~Ile113 (Accession # P04234)
Human CD3D-1274HCL Recombinant Human CD3D cell lysate Human Cell N/A
Human CD3D & CD3E-944HCL Recombinant Human CD3D & CD3E cell lysate Human Cell N/A
Human CD3D & CD3E-1714HCL Recombinant Human CD3D & CD3E cell lysate Human Cell N/A
Human CD3D-5283H Recombinant Human CD3D Protein (Met1-Ala105), C-His tagged Mammalian cells C-His Met1-Ala105
Human CD3D-3173HF Recombinant Full Length Human CD3D Protein, GST-tagged In Vitro Cell Free System GST 171 amino acids
Human CD3D-464H Recombinant Human CD3D Protein (Met1-Ala105), Flag-Fc-tagged, Biotinylated HEK293 Flag/Fc Met1-Ala105
Human CD3D-3172HF Recombinant Full Length Human CD3D Protein In Vitro Cell Free System 597 amino acids
Human CD3D-5284H Recombinant Human CD3D Protein (Met1-Ala105), C-Fc tagged Mammalian cells C-Fc Met1-Ala105
Human CD3D-28H Active Recombinant Human CD3D Protein (Phe22-Ala105), C-Fc-tagged HEK293 C-Fc Phe22-Ala105
Human CD3D-1293H Recombinant Human CD3D protein(Met1-Ala105), hFc&FLAG-tagged HEK293 C-hFc&FLAG Met1-Ala105
Human CD3D-137H Recombinant Human CD3D Protein, His-tagged HEK293 His 171
Human CD3D-1458H Recombinant Human CD3D Protein (Phe22-Ala105), N-His tagged E.coli N-His Phe22-Ala105
Mouse Cd3d-1903M Recombinant Mouse Cd3d protein, His-tagged E.coli His Phe22~Met104 (Accession # P04235)
Mouse CD3D-865M Recombinant Mouse CD3D Protein, Fc-tagged HEK293 Fc
Mouse CD3D & CD3E-1076MCL Recombinant Mouse CD3D & CD3E cell lysate Human Cell N/A
Mouse CD3D & CD3E-1726MCL Recombinant Mouse CD3D & CD3E cell lysate Human Cell N/A
Mouse CD3D-1381MCL Recombinant Mouse CD3D cell lysate Human Cell N/A
Rat CD3D-1250R Recombinant Rat CD3D Protein Mammalian Cell His
Rat Cd3d-1906R Recombinant Rat Cd3d protein, His-tagged E.coli His Phe22~Gly106
Rat CD3D-908R Recombinant Rat CD3D Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat CD3D-908R-B Recombinant Rat CD3D Protein Pre-coupled Magnetic Beads HEK293
Dog CD3D-673D Recombinant Dog CD3D Protein, His-tagged E.coli N-His Phe45-Lys194
Canine CD3D-1056C Recombinant Canine CD3D Protein, Fc-tagged HEK293 Fc
Cattle CD3D-1901C Recombinant Cattle CD3D protein, His & GST-tagged E.coli His/GST Val19~Ala102 (Accession # Q28072)
Cynomolgus CD3D-1182C Recombinant Cynomolgus CD3D protein, hFc-tagged HEK293 hFc Met1-Ala105
Cynomolgus CD3D-1183C Recombinant Cynomolgus CD3D protein, His-tagged HEK293 His Phe22-Ala105
Cynomolgus CD3E&CD3D-209C Recombinant Cynomolgus CD3E&CD3D protein, FLAG-Fc-tagged HEK293 FLAG-Fc Met1-Ala105&Met1-Asp117
Cynomolgus Monkey CD3E-306C Recombinant Cynomolgus CD3D & CD3E, His-Fc & Flag-Fc tagged Human Cell Fc
Cynomolgus Monkey CD3D-389C Recombinant Cynomolgus CD3D Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey CD3E&CD3D-220C Recombinant Cynomolgus CD3E&CD3D, His-Fc&Flag-Fc tagged HEK293 Flag/Fc/His
Cynomolgus Monkey CD3E&CD3D-187C Recombinant Cynomolgus CD3E&CD3D, His & flag-tagged HEK293 His/Flag
Cynomolgus Monkey CD3D & CD3E-1179CCL Recombinant Cynomolgus CD3D & CD3E cell lysate Human Cell N/A
Cynomolgus Monkey CD3D-1466CCL Recombinant Cynomolgus CD3D cell lysate Human Cell N/A
Cynomolgus Monkey CD3D-137C-B Recombinant Cynomolgus Monkey CD3D Protein Pre-coupled Magnetic Beads HEK293
Cynomolgus Monkey CD3D-137C Recombinant Cynomolgus Monkey CD3D Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cynomolgus monkey CD3D-136C Recombinant Cynomolgus monkey CD3D Protein, His-tagged HEK293 His 171
Homo sapiens (Human) RFL12764HF Recombinant Full Length Human T-Cell Surface Glycoprotein Cd3 Delta Chain(Cd3D) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (22-171)
Mus musculus (Mouse) RFL6965MF Recombinant Full Length Mouse T-Cell Surface Glycoprotein Cd3 Delta Chain(Cd3D) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (22-173)
Ovis aries (Sheep) RFL34411OF Recombinant Full Length Sheep T-Cell Surface Glycoprotein Cd3 Delta Chain(Cd3D) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (22-167)
Rattus norvegicus (Rat) RFL11357RF Recombinant Full Length Rat T-Cell Surface Glycoprotein Cd3 Delta Chain(Cd3D) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (22-173)
Sheep CD3D-1904S Recombinant Sheep CD3D protein, His-tagged E.coli His Val19~Thr99 (Accession # P18438)
Pig CD3D-1905P Recombinant Pig CD3D protein, His-tagged E.coli His Tyr22~Thr103 (Accession # Q764N2)
Chicken CD3D-7061C Recombinant Chicken CD3D Mammalian Cell His
Chicken CD3D-672C Recombinant Chicken CD3D Protein, His-tagged E.coli N-His Leu26-Lys175
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

CD3D involved in several pathways and played different roles in them. We selected most pathways CD3D participated on our site, such as Hematopoietic cell lineage, T cell receptor signaling pathway, Chagas disease (American trypanosomiasis), which may be useful for your reference. Also, other proteins which involved in the same pathway with CD3D were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Hematopoietic cell lineageCD1D;CD8B1;IL3RA;FLT3;HLA-DRB3;ITGA6;CD9;CD59A;CD1d1
T cell receptor signaling pathwayNFATC2;CDC42;CD40LG;PIK3R1;PPP3R1;NCK1;RELA;PIK3CB;CD8A
Chagas disease (American trypanosomiasis)FAS;TRAF6;CD3E;C1QA;IL6;CALR;AKT2;Ccl12;MAPK3
MeaslesIL4;HSPA2;EIF2AK1;IFNA1;CD3G;CD3E;HSPA6;Cd209g;RELA
HTLV-I infectionCCND3;WNT2B;GPS2;VDAC2;POLD1;PIK3R1;WNT2;Fzd4;MRAS
Primary iAICDA;DCLRE1C;TAP2;PTPRC;IKBKG;IL2RG;BLNK;BTK;CD3D
nodeficiencyRFXAP;CD8B1;ORAI1;DCLRE1C;ICOS;IL7R;IKBKG;IGLL1;CD4

CD3D has several biochemical functions, for example, protein heterodimerization activity, transcription coactivator activity, transmembrane signaling receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CD3D itself. We selected most functions CD3D had, and list some proteins which have the same functions with CD3D. You can find most of the proteins on our site.

Function Related Protein
protein heterodimerization activitySOX5;MYF5;FZD1;KCNIP1;MCL1A;ODZ4;JDP2;SRI;GUCY1A3
transcription coactivator activityTDRD3;CBFB;TAF5L;CITED4;JUNB;CRSP7;ENY2;TCERG1;PRRX1
transmembrane signaling receptor activityTLR5;LILRB3;NRXN3;GABRQ;GPR182;VIPR1B;GP1BB;P2RX5;P2RX6

CD3D has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CD3D here. Most of them are supplied by our site. Hope this information will be useful for your research of CD3D.

NR3C1; CANX; FYN; CD3E

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