CD3D
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Official Full Name
CD3d molecule, delta (CD3-TCR complex)
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Overview
CD4 is a single chain transmembraneous glycoprotein (59 kDa) which belongs to the immunoglobulin superfamily. CD4 is present on a subset of T lymphocytes ("helper/inducer" T cells) and is also expressed at a lower level on monocytes, tissue macrophages and granulocytes. The antigen is involved in binding to MHC class II molecules. The intracellular domain of the antigen is associated with p56lck protein tyrosine kinase. T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits: CD3 gamma, CD3 delta, CD3 epsilon and CD3 zeta. These CD3 subunits are structurally related members of the immunoglobulins super family encoded by closely linked genes on human chromosome 11. The CD3 components have long cytoplasmic tails that associate with cytoplasmic signal transduction molecules. This association is mediated at least in part by a double tyrosine based motif present in a single copy in the CD3 subunits. CD3 may play a role in TCR induced growth arrest, cell survival and proliferation. The CD3 antigen is present on 68-82% of normal peripheral blood lymphocytes, 65-85% of thymocytes and Purkinje cells in the cerebellum. It is never expressed on B or NK cells. Decreased percentages of T lymphocytes may be observed in some autoimmune diseases. -
Synonyms
CD3D; CD3d molecule, delta (CD3-TCR complex); CD3d antigen, delta polypeptide (TiT3 complex) , T3D; T-cell surface glycoprotein CD3 delta chain; CD3 delta; OKT3, delta chain; CD3 antigen, delta subunit; T-cell receptor T3 delta chain; CD3d antigen, delta;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Canine
- Cattle
- Chicken
- Cynomolgus
- Cynomolgus monkey
- Cynomolgus Monkey
- Dog
- Homo sapiens (Human)
- Human
- Mouse
- Mus musculus (Mouse)
- Ovis aries (Sheep)
- Pig
- Rat
- Rattus norvegicus (Rat)
- Sheep
- E.coli
- E.coli expression system
- HEK293
- Human Cell
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- C
- hFc
- FLAG
- Fc
- Flag
- GST
- His
- Avi
- S
- Non
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
---|---|---|---|---|---|---|
Human | CD3E&CD3D-182H | Active Recombinant Human CD3E&CD3D, His-Fc&Flag-Fc tagged | HEK293 | His&Fc&Flag | Asp23-Asp126;Phe22-Ala105 | |
Human | CD3E & CD3D-375H | Active Recombinant Human CD3E & CD3D protein, His & Flag-tagged, Biotinylated | HEK293 | His&Flag | Asp 23 - Asp 126 (CD3E) & Phe 22 - Ala 105 (CD3D) | |
Human | CD3E & CD3D-376H | Active Recombinant Human CD3E & CD3D protein, His-tagged | HEK293 | His | Asp 23 - Asp 126 (CD3E) & Phe 22 - Ala 105 (CD3D) | |
Human | CD3E & CD3D-377H | Active Recombinant Human CD3E & CD3D Protein, His-Avi-tagged, Biotinylated | HEK293 | His&Avi | Asp 23-Asp 126(CD3E) & Phe 22-Ala 105(CD3D) | |
Human | CD3E&CD3D-219H | Active Recombinant Human CD3E&CD3D, His&flag-tagged | HEK293 | His&Flag | Met1-Ala105&Met1-Asp126 | |
Human | CD3D-2193H | Recombinant Human CD3D protein, His-tagged | HEK293 | His | Met1-Ala105 | |
Human | CD3D-163H | Rcombinant Human CD3D, flag-tagged | Human Cell | Flag | Met1-Ala105 | |
Human | CD3D-015H | Recombinant Human CD3D protein, His-tagged | HEK293 | His | Phe22-Ala105 | |
Human | CD3D-0799H | Recombinant Human CD3D Protein | Wheat Germ | Non | ||
Human | CD3D-10951H | Recombinant Human CD3D, His-tagged | E.coli | His | 22-171a.a. | |
Human | CD3D-0800H | Recombinant Human CD3D Protein, GST-Tagged | Wheat Germ | GST | ||
Human | CD3D-8542H | Recombinant Human CD3D, Fc-His tagged | Human Cell | His&Fc | Met1-Ala105 | |
Human | CD3D-1902H | Recombinant Human CD3D protein, His & S-tagged | E.coli | His&S | Gln18~Ile113 | |
Human | CD3D-1274HCL | Recombinant Human CD3D cell lysate | Human Cell | Non | ||
Human | CD3D & CD3E-944HCL | Recombinant Human CD3D & CD3E cell lysate | Human Cell | Non | ||
Human | CD3D & CD3E-1714HCL | Recombinant Human CD3D & CD3E cell lysate | Human Cell | Non | ||
Human | CD3D-5283H | Recombinant Human CD3D Protein (Met1-Ala105), C-His tagged | Mammalian cells | His | Met1-Ala105 | |
Human | CD3D-3173HF | Recombinant Full Length Human CD3D Protein, GST-tagged | In Vitro Cell Free System | GST | 171 amino acids | |
Human | CD3D-464H | Recombinant Human CD3D Protein (Met1-Ala105), Flag-Fc-tagged, Biotinylated | HEK293 | Fc&Flag | Met1-Ala105 | |
Human | CD3D-3172HF | Recombinant Full Length Human CD3D Protein | In Vitro Cell Free System | 597 amino acids | ||
Human | CD3D-5284H | Recombinant Human CD3D Protein (Met1-Ala105), C-Fc tagged | Mammalian cells | Fc | Met1-Ala105 | |
Human | CD3D-28H | Active Recombinant Human CD3D Protein (Phe22-Ala105), C-Fc-tagged | HEK293 | Fc | Phe22-Ala105 | |
Human | CD3D-1293H | Recombinant Human CD3D protein(Met1-Ala105), hFc&FLAG-tagged | HEK293 | C-hFc&FLAG | Met1-Ala105 | |
Human | CD3D-137H | Recombinant Human CD3D Protein, His-tagged | HEK293 | His | 171 | |
Human | CD3D-1458H | Recombinant Human CD3D Protein (Phe22-Ala105), N-His tagged | E.coli | His | Phe22-Ala105 | |
Mouse | Cd3d-1903M | Recombinant Mouse Cd3d protein, His-tagged | E.coli | His | Phe22~Met104 | |
Mouse | CD3D-865M | Recombinant Mouse CD3D Protein, Fc-tagged | HEK293 | Fc | Met1-Ala105 | |
Mouse | CD3D & CD3E-1076MCL | Recombinant Mouse CD3D & CD3E cell lysate | Human Cell | Non | ||
Mouse | CD3D & CD3E-1726MCL | Recombinant Mouse CD3D & CD3E cell lysate | Human Cell | Non | ||
Mouse | CD3D-1381MCL | Recombinant Mouse CD3D cell lysate | Human Cell | Non | ||
Rat | CD3D-1250R | Recombinant Rat CD3D Protein | Mammalian Cell | His | ||
Rat | Cd3d-1906R | Recombinant Rat Cd3d protein, His-tagged | E.coli | His | Phe22~Gly106 | |
Rat | CD3D-908R | Recombinant Rat CD3D Protein, His (Fc)-Avi-tagged | HEK293 | His&Fc&Avi | ||
Rat | CD3D-908R-B | Recombinant Rat CD3D Protein Pre-coupled Magnetic Beads | HEK293 | |||
Dog | CD3D-673D | Recombinant Dog CD3D Protein, His-tagged | E.coli | His | Phe45-Lys194 | |
Canine | CD3D-1056C | Recombinant Canine CD3D Protein, Fc-tagged | HEK293 | Fc | Met1-Thr103 | |
Cattle | CD3D-1901C | Recombinant Cattle CD3D protein, His & GST-tagged | E.coli | His&GST | Val19~Ala102 | |
Cynomolgus | CD3D-1182C | Recombinant Cynomolgus CD3D protein, hFc-tagged | HEK293 | Fc | Met1-Ala105 | |
Cynomolgus | CD3D-1183C | Recombinant Cynomolgus CD3D protein, His-tagged | HEK293 | His | Phe22-Ala105 | |
Cynomolgus | CD3E&CD3D-209C | Recombinant Cynomolgus CD3E&CD3D protein, FLAG-Fc-tagged | HEK293 | Fc&Flag | Met1-Ala105&Met1-Asp117 | |
Cynomolgus Monkey | CD3E-306C | Recombinant Cynomolgus CD3D & CD3E, His-Fc & Flag-Fc tagged | Human Cell | Fc | Met1-Asp117;Met1-Ala105 | |
Cynomolgus Monkey | CD3D-389C | Recombinant Cynomolgus CD3D Protein, His-tagged | Mammalian Cell | His | ||
Cynomolgus Monkey | CD3E&CD3D-220C | Recombinant Cynomolgus CD3E&CD3D, His-Fc&Flag-Fc tagged | HEK293 | His&Fc&Flag | Gln22-Asp117 | |
Cynomolgus Monkey | CD3E&CD3D-187C | Recombinant Cynomolgus CD3E&CD3D, His & flag-tagged | HEK293 | His&Flag | Gln22-Asp117;Phe22-Ala105 | |
Cynomolgus Monkey | CD3D & CD3E-1179CCL | Recombinant Cynomolgus CD3D & CD3E cell lysate | Human Cell | Non | ||
Cynomolgus Monkey | CD3D-1466CCL | Recombinant Cynomolgus CD3D cell lysate | Human Cell | Non | ||
Cynomolgus Monkey | CD3D-137C-B | Recombinant Cynomolgus Monkey CD3D Protein Pre-coupled Magnetic Beads | HEK293 | |||
Cynomolgus Monkey | CD3D-137C | Recombinant Cynomolgus Monkey CD3D Protein, His (Fc)-Avi-tagged | HEK293 | His&Fc&Avi | ||
Cynomolgus monkey | CD3D-136C | Recombinant Cynomolgus monkey CD3D Protein, His-tagged | HEK293 | His | 171 | |
Homo sapiens (Human) | RFL12764HF | Recombinant Full Length Human T-Cell Surface Glycoprotein Cd3 Delta Chain(Cd3D) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (22-171) | |
Mus musculus (Mouse) | RFL6965MF | Recombinant Full Length Mouse T-Cell Surface Glycoprotein Cd3 Delta Chain(Cd3D) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (22-173) | |
Ovis aries (Sheep) | RFL34411OF | Recombinant Full Length Sheep T-Cell Surface Glycoprotein Cd3 Delta Chain(Cd3D) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (22-167) | |
Rattus norvegicus (Rat) | RFL11357RF | Recombinant Full Length Rat T-Cell Surface Glycoprotein Cd3 Delta Chain(Cd3D) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (22-173) | |
Sheep | CD3D-1904S | Recombinant Sheep CD3D protein, His-tagged | E.coli | His | Val19~Thr99 | |
Pig | CD3D-1905P | Recombinant Pig CD3D protein, His-tagged | E.coli | His | Tyr22~Thr103 | |
Chicken | CD3D-7061C | Recombinant Chicken CD3D | Mammalian Cell | His | ||
Chicken | CD3D-672C | Recombinant Chicken CD3D Protein, His-tagged | E.coli | His | Leu26-Lys175 |
- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
CD3D involved in several pathways and played different roles in them. We selected most pathways CD3D participated on our site, such as Hematopoietic cell lineage, T cell receptor signaling pathway, Chagas disease (American trypanosomiasis), which may be useful for your reference. Also, other proteins which involved in the same pathway with CD3D were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Hematopoietic cell lineage | IL3RA;CD1B;GYPA;IL11;Il6ra;Cd24a;CD9;CD59;GP5 |
T cell receptor signaling pathway | TEC;EVLB;FYN;CABIN1;RAF1;CD40LG;SLA1;HRAS;CD3G |
Chagas disease (American trypanosomiasis) | FOS;PIK3CA;GNAL;FAS;MAPK13;Fasl;GNA11;TLR2;PPP2CB |
Measles | GSK3B;Ifna15;PIK3CA;CD3E; CD3D;TRAF6;CCNE2;CD28;SH2D1A;DOK1 |
HTLV-I infection | VDAC1;PIK3CB;CDC20;ATM;CD3E;HLA-B;RANBP1;PIK3R2;ELK1 |
Primary i | CD4;IKBKG;PTPRC;ZAP70;CD40LG;CD3E;ICOS;TAP2;IL7R |
nodeficiency | RFXANK;TAP1;Cd79a, Cd79b;RAG1;IGLL1;BLNK;CD19;ICOS;CD8B |
CD3D has several biochemical functions, for example, protein heterodimerization activity, transcription coactivator activity, transmembrane signaling receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CD3D itself. We selected most functions CD3D had, and list some proteins which have the same functions with CD3D. You can find most of the proteins on our site.
Function | Related Protein |
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protein heterodimerization activity | TYR;CRLF1;POLE3;HIST2H4A;PDGFA;MAP3K7;CUL3;VOX;WHRN |
transcription coactivator activity | GRIP1;SRA1;GATA3;TADA2B;MAML2;MED26;CITED4;USP22;TADA3 |
transmembrane signaling receptor activity | EMR4;TLR18;KIR2DS2;P2RX5;THBD;OR115-6;PTH1RB;KLRD1;CLEC2H |
CD3D has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CD3D here. Most of them are supplied by our site. Hope this information will be useful for your research of CD3D.
NR3C1; CANX; FYN; CD3E
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