Cd19

  • Official Full Name

    CD19 molecule

  • Overview

    Lymphocytes proliferate and differentiate in response to various concentrations of different antigens. The ability of the B cell to respond in a specific, yet sensitive manner to the various antigens is achieved with the use of low-affinity antigen receptors. This gene encodes a cell surface molecule which assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation.
  • Synonyms

    B4; CVID3; MGC12802; CD19; B-lymphocyte antigen CD19; OTTHUMP00000122551; differentiation antigen CD19; T-cell surface antigen Leu-12; B-lymphocyte surface antigen B4;

  • Recombinant Proteins
  • GMP Proteins
  • Cell & Tissue Lysates
  • Chromatography Reagents
  • Protein Pre-coupled Magnetic Beads
  • 314-556 aa
  • Canine
  • Cynomolgus
  • Cynomolgus/Rhesus
  • Cynomolgus/Rhesus macaque
  • Gln21-Trp291
  • Human
  • Monkey
  • Mouse
  • Mus musculus (Mouse)
  • Rabbit
  • Rat
  • Rhesus macaque
  • Baculovirus-Insect Cells
  • C-His
  • CHO
  • CHO cells
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293 Stable Cells
  • HEK293T
  • Human Cell
  • Human cells
  • In Vitro Cell Free System
  • Mammalian cells
  • N-His
  • Wheat Germ
  • C
  • His
  • Fc
  • Avi
  • Flag
  • GST
  • Myc
  • T7
  • lIgG2b
  • mFc
  • DDK
  • Non
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CD19-3307H Active Recombinant Human CD19 protein, Fc-tagged HEK293 Fc Pro 20 - Pro 278
Human CD19-3309H Active Recombinant Human CD19 protein, His-tagged HEK293 His Pro 20 - Lys 291
Human CD19-3309HP Active Recombinant Human CD19 protein, His-tagged, R-PE labeled HEK293 His Met1-Lys291
Human CD19-12H Active Recombinant Human CD19 protein, Fc-tagged, biotinylated HEK293 Fc Pro20-Val279
Human CD19-3308H Active Recombinant Human CD19, Fc tagged HEK293 Fc Pro20-Lys291
Human CD19-07H Active Recombinant Human CD19 Protein, Fc-tagged, Atto 488 conjugated CHO Fc Glu21-Lys291
Human CD19-3309HA Active Recombinant Human CD19 protein, His-tagged, APC labeled HEK293 His Met1-Lys291
Human CD19-06H Active Recombinant Human CD19 Protein, Fc-tagged, Alexa Fluor® 647 conjugated CHO Fc Glu21-Lys291
Human CD19-3308HAF555 Active Recombinant Human CD19 Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Fc Pro20-Lys291
Human CD19-08H Active Recombinant Human CD19 Protein, Fc-tagged, Atto 647N conjugated CHO Fc Glu21-Lys291
Human CD19-051H Active Recombinant Human CD19 protein, Fc/Avi-tagged, Biotinylated CHO cells Fc&Avi Glu21- Lys291
Human CD19-3308HAF488 Active Recombinant Human CD19 Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Fc Pro20-Lys291
Human CD19-3307HAF647 Active Recombinant Human CD19 Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Fc Pro20-Pro278
Human CD19-3307HAF555 Active Recombinant Human CD19 Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Fc Pro20-Pro278
Human CD19-3308HF Active Recombinant Human CD19 Protein, Fc-tagged, FITC conjugated HEK293 Fc Pro20-Lys291
Human CD19-3308HAF647 Active Recombinant Human CD19 Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Fc Pro20-Lys291
Human CD19-559H Active Recombinant Human CD19 Protein, His-Avi-tagged, Biotinylated HEK293 His&Avi Pro 20 - Lys 291
Human CD19-3307HF Active Recombinant Human CD19 Protein, Fc-tagged, FITC conjugated HEK293 Fc Pro20-Pro278
Human CD19-307HG Active GMP Recombinant Human CD19 protein HEK293 DNA sequence encoding Human CD19 (UniProtKB/Swiss-Prot: P15391.6) was expressed with His tag at the C-terminal.
Human CD19-05H Active Recombinant Human CD19 Protein, Fc-tagged, Alexa Fluor® 488 conjugated CHO Fc Glu21-Lys291
Human CD19-3307HAF488 Active Recombinant Human CD19 Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Fc Pro20-Pro278
Human CD19-3307HP Recombinant Human CD19 protein, Fc-tagged, R-PE labeled HEK293 Fc
Human CD19-558H Active Recombinant Human CD19, His-tagged, Biotinylated HEK293 His Met1-Lys291
Human CD19-409H Recombinant Human CD19 Protein, DDK/His-tagged HEK293 His&Flag Pro20 – Lys291
Human CD19-280H Recombinant Human CD19, Fc-tagged, Biotinylated HEK293 Fc Pro20-Lys291
Human CD19-27864TH Recombinant Human CD19 Wheat Germ Non 90 amino acids
Human CD19-25H Recombinant Human CD19 protein, His-tagged HEK293 His Pro20-Val279
Human CD19-150H Active Recombinant Human CD19 protein, His-tagged HEK293 His Met1-Lys291
Human CD19-0732H Recombinant Human CD19 Protein, GST-Tagged Wheat Germ GST
Human CD19-408H Recombinant Human CD19 Protein, Fc-tagged HEK293 Fc
Human CD19-1907H Recombinant Human CD19 protein, His & GST-tagged E.coli His&GST Ala160~Lys258
Human CD19-2005HCL Recombinant Human CD19 cell lysate Human Cell Non
Human CD19-342H Active Recombinant Human CD19 protein, His-tagged, FITC-labeled HEK293 His Pro 20 - Lys 291
Human CD19-3308HP Recombinant Human CD19 protein, Fc-tagged, R-PE labeled HEK293 Fc
Human CD19-3043H Recombinant Human CD19 Protein, MYC/DDK-tagged HEK293 Myc&DDK
Human CD19-4994H Recombinant Human CD19 protein, His&Myc-tagged HEK293 His&Myc 20-291aa
Human CD19-408HAF488 Recombinant Human CD19 Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Fc
Human CD19-408HP Recombinant Human CD19 protein, Fc-tagged, R-PE labeled HEK293 Fc
Human CD19-3307HA Recombinant Human CD19 protein, Fc-tagged, APC labeled HEK293 Fc
Human CD19-3309HAF555 Recombinant Human CD19 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His Pro 20 - Lys 291
Human CD19-809H Recombinant Human CD19 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc&DDK
Human CD19-281H Recombinant Human CD19 Protein, Fc-Avi-tagged, Biotinylated HEK293 Fc&Avi Pro 20 - Lys 291
Human CD19-3308HA Recombinant Human CD19 protein, Fc-tagged, APC labeled HEK293 Fc
Human CD19-408HAF555 Recombinant Human CD19 Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Fc
Human CD19-15H Recombinant Human CD19 protein (Glu21-Arg277), His-tagged Baculovirus-Insect Cells His Glu21-Arg277
Human CD19-3309HB Recombinant Human CD19 protein, His-tagged, Biotinylated HEK293 His Met1-Lys291
Human CD19-408HA Recombinant Human CD19 protein, Fc-tagged, APC labeled HEK293 Fc
Human CD19-3309HAF647 Recombinant Human CD19 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His 283
Human CD19-32HFL Recombinant Full Length Human CD19 Protein, C-Flag-tagged Mammalian cells Flag
Human CD19-765H Recombinant Human CD19 Protein, DYKDDDDK-tagged Human cells Flag
Human CD19-340H Active Recombinant Human CD19 Protein, LIgG2b Fc-tagged, low endotoxin HEK293 lIgG2b Pro 20 - Lys 291
Human CD19-408HAF647 Recombinant Human CD19 Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Fc
Human CD19-130H Recombinant Human CD19 Protein, Fc-tagged HEK293 Fc 556
Human CD19-2359H Recombinant Human CD19 protein, His-tagged E.coli His 20-291aa
Human CD19-341H Recombinant Human CD19 Protein (Pro 20 - Lys 291), Fc-tagged, FITC-Labeled HEK293 Fc Pro 20 - Lys 291
Human CD19-3309HF Recombinant Human CD19 Protein, His-tagged, FITC conjugated HEK293 His 283
Human CD19-4661H Recombinant Human CD19 Protein, His-tagged, APC-Labeled HEK293 His Pro 20 - Lys 291
Human CD19-2991HF Recombinant Full Length Human CD19 Protein, GST-tagged In Vitro Cell Free System GST 556 amino acids
Human CD19-301184H Recombinant Human CD19 protein, GST-tagged E.coli GST Glu21-Lys291
Human CD19-408HF Recombinant Human CD19 Protein, Fc-tagged, FITC conjugated HEK293 Fc
Human CD19-8686M Whole Blood CD19 protein-coupled magnetic MicroBeads
Human CD19-26H Recombinant Human CD19 Protein (20-291), C-His-tagged CHO His 20-291
Human CD19-2358H Recombinant Human CD19 protein, His-tagged E.coli His 20-291aa
Human CD19-3063H Recombinant Human CD19 protein, His-tagged, Alexa Fluor 488-Labeled HEK293 His Pro 20-Lys 291
Human CD19-5749M LRSC CD19 protein-coupled magnetic MicroBeads
Human CD19-127H Recombinant Human CD19 Protein, Fc-tagged, Biotinylated HEK293 Fc 556
Human CD19-3309HAF488 Recombinant Human CD19 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His 283
Human CD19-3064H Recombinant Human CD19 protein, His-tagged, Alexa Fluor 647-Labeled HEK293 His Pro 20-Lys 291
Human CD19-4923M Whole Blood REAlease CD19 protein-coupled magnetic MicroBeads
Human CD19-129H Recombinant Human CD19 Protein, His-tagged HEK293 His 556
Human CD19-534H Recombinant Human CD19 Protein, His (Fc)-Avi-tagged HEK293 His&Fc&Avi
Human CD19-0726H Recombinant Human CD19 Protein (Pro20-Lys291), His tagged E.coli His Pro20-Lys291
Human CD19-2947H Recombinant Human CD19 protein, His-tagged, Site-Specific AF 488-Labeled HEK293 Stable Cells C-His Met1-Lys291
Human CD19-7098M Active CD19 protein-coupled magnetic Beads HEK293 Pro 20 - Lys 291
Human CD19-128H Recombinant Human CD19 Protein, Fc-tagged HEK293 Fc 556
Human CD19-4669H Active Recombinant Human CD19 protein, His-tagged, Site-specific PE-Labeled HEK293 C-His Pro 20 - Lys 291
Human CD19-2948H Recombinant Human CD19 protein, His-tagged, Site-Specific AF 647-Labeled HEK293 Stable Cells C-His Met1-Lys291
Human CD19-005M CD19 protein-coupled magnetic beads
Human CD19-534H-B Recombinant Human CD19 Protein Pre-coupled Magnetic Beads HEK293
Human CD19-3069H Active Recombinant Human CD19 protein, mFc-tagged HEK293 mFc Pro 20-Lys 291
Human CD19-1602H Recombinant Human CD19 Protein (Met1-Trp290), C-His tagged Mammalian cells His Met1-Trp290
Human CD19-4660H Active Recombinant Human CD19 protein, His-tagged, Site-specific APC-Labeled HEK293 C-His Pro 20 - Lys 291
Human CD19-711M CD19 protein-coupled magnetic MicroBeads
Human CD19-5315H Recombinant Human CD19 Protein (Met1-Lys291), C-His tagged Mammalian cells His Met1-Lys291
Human CD19-3042M Buffy Coat CD19 protein-coupled magnetic MicroBeads
Human CD19-754M Leukopak CD19 protein-coupled magnetic MicroBeads
Mouse CD19-01M Active Recombinant Mouse CD19 Chimera Protein CHO
Mouse Cd19-3308MAF488 Active Recombinant Mouse Cd19 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His Met1-Gly287, 282
Mouse Cd19-3308MF Active Recombinant Mouse Cd19 Protein, His-tagged, FITC conjugated HEK293 His Met1-Gly287, 282
Mouse Cd19-3308MAF647 Active Recombinant Mouse Cd19 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His Met1-Gly287, 282
Mouse Cd19-3308MAF555 Active Recombinant Mouse Cd19 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His Met1-Gly287, 282
Mouse Cd19-1908M Recombinant Mouse Cd19 protein, His & T7-tagged E.coli His&T7 Arg19~Gly287
Mouse Cd19-3308M Recombinant Mouse Cd19 protein, His-tagged HEK293 His Met1-Gly287
Mouse CD19-2164MCL Recombinant Mouse CD19 cell lysate Human Cell Non
Mouse CD19-2913M Spleen CD19 protein-coupled magnetic MicroBeads
Mouse Cd19-828M Recombinant Mouse Cd19 Protein, MYC/DDK-tagged HEK293T Myc&DDK
Mouse CD19-5078M CD19 protein-coupled magnetic MicroBeads
Mouse Cd19-3308MB Active Recombinant Mouse Cd19 protein, His-tagged, Biotinylated HEK293 His Met1-Gly287
Rat Cd19-1909R Recombinant Rat Cd19 protein, His & GST-tagged E.coli His&GST Arg19~Gly287
Rat CD19-3065R Recombinant Rat CD19 protein, His-tagged HEK293 His Arg 19-Gly 287
Monkey CD19-159CF Recombinant Monkey CD19 Protein, Fc-tagged, FITC conjugated HEK293 Fc Pro20-Lys292
Monkey CD19-315CF Recombinant Monkey CD19 Protein, Fc-tagged, FITC conjugated HEK293 Fc Met1-Lys292, 513
Monkey CD19-315CAF647 Recombinant Monkey CD19 Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Fc Met1-Lys292, 513
Monkey CD19-159CAF488 Recombinant Monkey CD19 Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Fc Pro20-Lys292
Monkey CD19-159CAF555 Recombinant Monkey CD19 Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Fc Pro20-Lys292
Monkey CD19-159CAF647 Recombinant Monkey CD19 Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Fc Pro20-Lys292
Monkey CD19-315CAF488 Recombinant Monkey CD19 Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Fc Met1-Lys292, 513
Monkey CD19-315CAF555 Recombinant Monkey CD19 Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Fc Met1-Lys292, 513
Rabbit CD19-3067R Recombinant Rabbit CD19 protein, His-tagged HEK293 His Gln 21-Gly 278
314-556 aa CD19-3083H Recombinant Human CD19 protein, His-tagged N-His 314-556 aa
Canine CD19-3066C Recombinant Canine CD19 protein, His-tagged HEK293 His Gln 21-Gly 297
Cynomolgus CD19-315C Recombinant Cynomolgus CD19 Protein, Fc-tagged HEK293 Fc Met1-Lys292
Cynomolgus CD19-1075C Recombinant Cynomolgus CD19 Protein (Met1-Lys292), His-tagged HEK293 His Met1-Lys292
Cynomolgus/Rhesus CD19-1086C Recombinant Cynomolgus/Rhesus CD19 protein, His-tagged, Biotinylated HEK293 His Met1-Lys292
Cynomolgus/Rhesus macaque CD19-3068C Recombinant Cynomolgus/Rhesus macaque CD19 protein, His-tagged HEK293 His Pro 20-Lys 292
Gln21-Trp291 CD19-1489C Recombinant Cynomolgus CD19 protein, His-tagged C-His Gln21-Trp291
Mus musculus (Mouse) RFL30464MF Recombinant Full Length Mouse B-Lymphocyte Antigen Cd19(Cd19) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (19-547)
Rhesus macaque CD19-159C Recombinant Rhesus macaque CD19 protein, Fc-tagged HEK293 Fc Pro 20 - Lys 292
Rhesus macaque CD19-131R Recombinant Rhesus macaque CD19 Protein, Fc-tagged HEK293 Fc 557
Rhesus macaque CD19-159CP Recombinant Rhesus macaque CD19 protein, Fc-tagged, R-PE labeled HEK293 Fc
Rhesus macaque CD19-159CA Recombinant Rhesus macaque CD19 protein, Fc-tagged, APC labeled HEK293 Fc
  • Background
  • Quality Guarantee
  • Case Study
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource
CD19-7.jpg

Fig1. CD19 molecular structure. (Kemeng Wang, 2012)

What is CD19 protein?

CD19 gene (CD19 molecule) is a protein coding gene which situated on the short arm of chromosome 16 at locus 16p11. This gene encodes a member of the immunoglobulin gene superfamily. Expression of this cell surface protein is restricted to B cell lymphocytes. This protein is a reliable marker for pre-B cells but its expression diminishes during terminal B cell differentiation in antibody secreting plasma cells. This protein forms a complex with several membrane proteins including complement receptor type 2 (CD21) and tetraspanin (CD81) and this complex reduces the threshold for antigen-initiated B cell activation. Activation of this B-cell antigen receptor complex activates the phosphatidylinositol 3-kinase signalling pathway and the subsequent release of intracellular stores of calcium ions. This protein is a target of chimeric antigen receptor (CAR) T-cells used in the treatment of lymphoblastic leukemia. The CD19 protein is consisted of 556 amino acids and CD19 molecular weight is approximately 61.1 kDa.

What is the function of CD19 protein?

CD19 belongs to the immunoglobulin superfamily and is a type I transmembrane protein with a single transmembrane domain, cytoplasmic C-terminal and extracellular N-terminal. As the main signaling component of a multimolecular complex, CD19 acts together with complement receptor CD21, quadritransmembrane protein CD81 (TAPA-1) and CD225 on the surface of mature B cells to increase the sensitivity of B cells to antigens and promote the proliferation and differentiation of B cells. In addition, CD19 plays a crucial role in the development, maturation and immune response of B cells by interacting with intracellular signaling kinases to enhance BCR-activated signaling and is essential for the expansion and humoral immune response of B cells. CD19, whose expression begins in pre-B cells until it finally differentiates into plasma cells, is one of the most reliable surface biomarkers for B cells.

CD19 related signaling pathway

CD19 regulates the activation, proliferation, and differentiation of B cells by forming multimolecular complexes with BCR and other surface molecules such as CD21, CD81, and CD225. CD19 plays a critical role in the maturation and survival of B cells by enhancing BCR-induced signaling, lowering the signaling threshold required for B cell activation, and amplifies BCR signaling by recruiting and activating downstream protein kinases such as SrC-family kinases, Ras family kinases, Abl, Btk, Vav, Grb2, and PI3K. In addition, CD19 is involved in signaling independent of BCR, for example by binding to CD21 in response to activation of the complement fragment C3d.

CD19 related diseases

CD19 is a B-cell surface marker that has been associated with a variety of diseases, especially B-cell-associated blood tumors. Expression of CD19 is highly conserved in most acute lymphoblastic leukemias (ALL), chronic lymphoblastic leukemias (CLL), and B-cell lymphomas, making it a therapeutic target for these diseases. For example, CAR T-cell therapies targeting CD19 have been approved to treat certain types of B-cell malignancies, such as relapsed or refractory diffuse large B-cell lymphoma (DLBCL). In addition, CD19-targeted therapies also include monoclonal antibodies, immunotoxins, bisspecific antibodies and antibody drug conjugations, and are being evaluated in clinical trials for their potential and efficacy in the treatment of B-cell-related diseases.

Bioapplications of CD19

CAR-T cell therapies targeting CD19, such as axicabtagene ciloleucel (axi-cel) and tisagenlecleucel (Kymriah), have been approved for the treatment of certain types of B-cell malignancies and are continuing to expand their indications. CD19 targeting therapy also includes monoclonal antibodies, such as rituximab; Bisspecific antibodies, such as blinatumomab, promote the killing of tumor cells by T cells by simultaneously binding to CD19 and CD3 molecules. Antibody drug conjugators (ADCs) technology also involves CD19 targeted therapy, which enables precise killing of tumor cells by coupling cytotoxic drugs to anti-CD19 antibodies via specific linkers.

High Purity

SDS-PAGE (CD19-12H).jpg

Fig1. SDS-PAGE (CD19-12H)

.

SDS-PAGE (CD19-07H).jpg

Fig2. SDS-PAGE (CD19-07H)

Case Study 1: Asen Bagashev, 2018

To distinguish between epitope loss and surface localization defects, researchers used retrovirus transduction and gene editing techniques to create cell lines expressing the CD19 exon 2 variant (CD19ex2vs) with vesicular stomatitis virus G protein (VSVg) tag. These cell lines were negative in live cell flow cytometry using anti-VSVG antibodies and were resistant to killing by VSVG-directed antibody drug conjugators (ADCs), indicating a defect in surface localization. In fact, pulse-tracking and α-mannosidase inhibitor experiments showed that all CD19ex2vs acquired high mannose-type sugars specific to the ER, but not complex sugar chains synthesized in the Golgi. When fusing with green fluorescent protein (GFP), CD19ex2vs (including mutants lacking relevant disulfide bonds) co-localised with ER markers, suggesting a misalignment of the protein. Mass spectrometry analysis of CD19 interacting proteins revealed that CD19ex2vs failed to bind to the key quad-transmembrane protein CD81, but instead interacted with endoplasmic reticulum resident molecular chaperones such as calnexin and ER transporters involved in antigen presentation.

CD19-1.jpg

Fig1. Western blot with anti-CD19 or antiactin antibody of protein extracts from the transduced Nalm6 cell lines after treatment with DMSO or swainsonine.

CD19-2.jpg

Fig2. Live-cell flow cytometry for empty (black), CD19-FL (blue), CD19-Δex2 (green), and CD19-105R (red).

Case Study 2: Xiaocui He, 2018

BCR is essential for the development and maturation of B cells, and many B-cell lymphomas, such as Burkitt Lymphoma (BL), rely on sustained BCR signaling to promote tumor growth, a process driven by the immune receptor tyrosine activation motif (ITAM) and PI3 kinase (PI3K) signaling pathways. In this study, researchers used CRISPR/Cas9 technology to knock out the BCR and B cell co-receptor genes in the human BL cell line Ramos. The study found that Ramos B cells require the expression of the BCR signaling component Igβ (CD79b) and co-receptor CD19 to maintain their adaptive and competitive growth. In addition, even in the absence of any other BCR component, Igβ can still be expressed on the surface of B cells and is close to CD19, transmitting signals in an ITAM-dependent manner.

CD19-3.jpg

Fig3. The expression of CD19 on the surface of different Ramos KO cells was determined by flow cytometry.

CD19-4.jpg

Fig4. Measurement of the Igβ:CD19 proximity by Fab-PLA.

Cd19 involved in several pathways and played different roles in them. We selected most pathways Cd19 participated on our site, such as PIK-Akt signaling pathway, Hematopoietic cell lineage, B cell receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Cd19 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
PIK-Akt signaling pathwayMTOR;LAMB2;YWHAH;GYS1;Il6ra;LAMC1;IFNAR1;BCL2L1;EPO
Hematopoietic cell lineageCD2;Fcer2a;CSF1;CD37;ITGA2;CD1C;CD1D2;Kitl;IL1R1
B cell receptor signaling pathwayMAPK4;AKT1;LYN;TTC6;CRKL;NFKBIE;DOK1;RAC3;PIK3CA
Epstein-Barr virus infectionHLA-A;EIF2AK4;AKAP8L;CCNA1;CD19;PSMD13;GTF2B;MAP2K7;HDAC5
Primary iCD40;IKBKG;IL7R;ICOS;UNG;PTPRC;RAG1;Cd79a, Cd79b;AICDA
nodeficiencyDCLRE1C;CD40;CD40LG;LCK;CD3E;TAP1;AIRE;CD4;CD8B1

Cd19 has several biochemical functions, for example, protein binding, receptor signaling protein activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Cd19 itself. We selected most functions Cd19 had, and list some proteins which have the same functions with Cd19. You can find most of the proteins on our site.

Function Related Protein
protein bindingRBCK1;NR2F2;AAGAB;CCNB2;LOC149950;CXCL2;KCNJ15;EGLN3;SCFD1
receptor signaling protein activityGNAZ;cgr2b;BAG4;KLK1B3;BAG1;FCAR;RGS14A;Siglece;FLRT2

Cd19 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Cd19 here. Most of them are supplied by our site. Hope this information will be useful for your research of Cd19.

IGHM; IGHD; CD82; PIK3R3; CD9; PIK3R1; BTK; ARID3A

Research Area

Related articles

Xu, ZS; Zhang, JS; et al. Constitutive activation of NF-kappa B signaling by NOTCH1 mutations in chronic lymphocytic leukemia. ONCOLOGY REPORTS 33:1609-1614(2015).
Strauss, V; Kolle, SN; et al. Immunophenotyping does not improve predictivity of the local lymph node assay in mice. JOURNAL OF APPLIED TOXICOLOGY 35:434-445(2015).
  • Reviews
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Customer Reviews (3)

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Reviews
01/02/2023

    The manufacturer of CD19 protein has consistently provided outstanding technical support that has surpassed my expectations.

    08/18/2022

      This protein demonstrates remarkable purity, stability, and specificity, ensuring utmost accuracy and reproducibility in my research endeavors.

      06/29/2016

        Their dedication to customer satisfaction has been instrumental in overcoming obstacles and achieving successful results in my experiments.

        Q&As (5)

        Ask a question
        How does CAR-T cell therapy work to combat CD19-expressing cancers? 02/11/2023

        CAR-T cells are engineered to express a receptor that recognizes CD19 on the surface of cancerous B cells. When they encounter these cells, they destroy them.

        Are there any diseases associated with CD19 dysfunction? 12/07/2022

        CD19 deficiencies can lead to primary immunodeficiencies, making individuals more susceptible to infections.

        What are the potential side effects of CAR-T cell therapy targeting CD19? 01/26/2022

        Side effects may include cytokine release syndrome (CRS), neurologic toxicity, and long-term B-cell aplasia.

        What are some CD19-expressing malignancies that CAR-T cell therapy can target? 07/17/2021

        CAR-T cell therapy is used to treat B-cell malignancies such as acute lymphoblastic leukemia (ALL) and certain types of non-Hodgkin lymphoma.

        How effective is CAR-T cell therapy in treating CD19-expressing cancers? 08/26/2019

        CAR-T cell therapy has shown remarkable effectiveness in inducing remissions in patients with CD19-positive malignancies, particularly in those who have relapsed or failed conventional treatments.

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