CD79B

  • Official Full Name

    CD79b molecule, immunoglobulin-associated beta

  • Overview

    CD79 is a heterodimeric molecule comprised of an alpha-chain (CD79a) and beta-chain (CD79b). A 37-39 kD type I integral membrane protein CD79b is non-covalently associated with CD79a and cell surface IgM to form the B-cell receptor (BCR) complex. CD79b is
  • Synonyms

    CD79B; CD79b molecule, immunoglobulin-associated beta; CD79B antigen (immunoglobulin associated beta) , IGB; B-cell antigen receptor complex-associated protein beta chain; B29; Ig-beta; B-cell-specific glycoprotein B29; immunoglobulin-associated B29 protein; CD79b antigen (immunoglobulin-associated beta); IGB; AGM6;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Cynomolgus
  • Cynomolgus/ Rhesus
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Rat
  • Rhesus Macaque
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293F
  • HEK293T
  • Human Cell
  • Human Cells
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • C
  • His
  • DYKDDDDK
  • Fc
  • Flag
  • GST
  • hFc
  • His (Fc)
  • Avi
  • His|T7
  • human|IgG1|Fc
  • Myc
  • DDK
  • MYC
  • Myc|DDK
  • N/A
  • N
  • T7|His
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CD79B-27508TH Recombinant Human CD79B Wheat Germ N/A 229 amino acids
Human CD79B-143H Active Recombinant Human CD79B protein, His-tagged HEK293 His Ala 29 - Asp 159
Human CD79B-10976H Recombinant Human CD79B, GST-tagged E.coli GST C-term-201a.a.
Human CD79B-0858H Recombinant Human CD79B Protein, GST-Tagged Wheat Germ GST
Human CD79B-238H Recombinant Human CD79B protein, His-tagged HEK293 His Met1-Asp159
Human CD79B-239H Recombinant Human CD79B protein, Fc-tagged HEK293 human/IgG1/Fc 131
Human CD79B-397H Recombinant Human CD79b molecule, immunoglobulin-associated beta, His-tagged E.coli His
Human CD79B-89H Recombinant Human CD79B protein, T7/His-tagged E.coli T7/His
Human CD79B-239HP Recombinant Human CD79B protein, Fc-tagged, R-PE labeled HEK293 Fc
Human CD79B-3113H Recombinant Human CD79B Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human CD79B-912H Recombinant Human CD79B protein, His-Avi-tagged HEK293 His-Avi It contains Ala 29 - Asp 159.
Human CD79B-239HA Recombinant Human CD79B protein, Fc-tagged, APC labeled HEK293 Fc
Human CD79B-239HAF488 Recombinant Human CD79B Protein, hFc-tagged, Alexa Fluor 488 conjugated HEK293 hFc 131
Human CD79B-259HB Recombinant Human ICOSLG protein, His-Avi-tagged, Biotinylated HEK293 His-Avi Ala 29 - Asp 159
Human CD79B-239HAF647 Recombinant Human CD79B Protein, hFc-tagged, Alexa Fluor 647 conjugated HEK293 hFc 131
Human CD79B-239HAF555 Recombinant Human CD79B Protein, hFc-tagged, Alexa Fluor 555 conjugated HEK293 hFc 131
Human CD79B-209H Recombinant Human CD79B Protein, C-His-tagged E.coli C-His
Human CD79A & CD79B-212H Recombinant Human CD79A & CD79B protein, Flag & His-tagged HEK293 Flag/His
Human CD79B-0742H Recombinant Human CD79B Protein (Asn37-Pro226), N-His tagged E.coli N-His Asn37-Pro226
Human CD79B-239HF Recombinant Human CD79B Protein, hFc-tagged, FITC conjugated HEK293 hFc 131
Human CD79B-5372H Recombinant Human CD79B Protein (Met1-Asp159), C-His tagged Mammalian cells C-His Met1-Asp159
Human CD79B-3806H Recombinant Human CD79B protein, His-tagged E.coli His 29-229 aa
Human CD79B-4667H Recombinant Human CD79B Protein, His-tagged, PE-Labeled HEK293 His Ala 29 - Asp 159
Human CD79B-699H Recombinant Human CD79B Protein, His-tagged HEK293F N-His Ala29-Asp159
Human CD79B-2995H Active Recombinant Human CD79B protein, Fc-tagged HEK293 Fc Ala 29-Asp 159
Human CD79B-3296H Recombinant Human CD79B Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human CD79B-151H Recombinant Human CD79B Protein, DYKDDDDK-tagged Human Cells DYKDDDDK
Human CD79B-66HF Recombinant Full Length Human CD79B Protein In Vitro Cell Free System 229 amino acids
Human CD79B-3059HF Recombinant Full Length Human CD79B Protein, GST-tagged In Vitro Cell Free System GST 229 amino acids
Human CD79B-171H Recombinant Human CD79B Protein, Fc-tagged HEK293 Fc 229
Mouse Cd79b-6889M Recombinant Mouse Cd79b protein, His & T7-tagged E.coli His/T7 Val26~Pro225 (Accession # P15530)
Mouse Cd79b-6897M Recombinant Mouse Cd79b protein, His-tagged HEK293 His Val 26 - Asp 158
Mouse Cd79a & Cd79b-487M Recombinant Mouse Cd79a & Cd79b protein, His-tagged HEK293 His (Met1-Arg137) & Cd79b(Met1-Asp158)
Mouse CD79B-1827MCL Recombinant Mouse CD79B cell lysate Human Cell N/A
Mouse Cd79b-1222M Recombinant Mouse Cd79b Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse Cd79b-6898M Recombinant Mouse Cd79b(Val26-Asp158) Protein, C-Fc-tagged HEK293 Fc
Rat Cd79b-7487R Recombinant Rat Cd79b, Fc-tagged Human Cell Fc
Rat Cd79b-8776R Recombinant Rat Cd79b protein(Met1-Asp158), His-tagged HEK293 C-His Met1-Asp158
Rat CD79B-1323RCL Recombinant Rat CD79B cell lysate Human Cell N/A
Cynomolgus CD79B-2990C Recombinant Cynomolgus CD79B protein, His-Avi-tagged, Biotinylated HEK293 His-Avi Ala 30-Asp 161
Cynomolgus/ Rhesus CD79B-992C Recombinant Cynomolgus/Rhesus CD79B Protein (Met1-Asp161), His-tagged HEK293 His Met1-Asp161
Homo sapiens (Human) RFL17115HF Recombinant Full Length Human B-Cell Antigen Receptor Complex-Associated Protein Beta Chain(Cd79B) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (29-229)
Mus musculus (Mouse) RFL21867MF Recombinant Full Length Mouse B-Cell Antigen Receptor Complex-Associated Protein Beta Chain(Cd79B) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (26-228)
Rhesus Macaque CD79B-748R Recombinant Rhesus monkey CD79B Protein, His-tagged Mammalian Cell His
Rhesus Macaque CD79B-749R Recombinant Rhesus Macaque CD79B(Ala30-Asp161) Protein, C-Fc-tagged HEK293 Fc
Rhesus Macaque CD79B-750R Recombinant Rhesus Macaque CD79B(Ala30-Asp161) Protein, C-6*His-tagged HEK293 His
Rhesus Macaque CD79B-574R-B Recombinant Rhesus Macaque CD79B Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque CD79B-574R Recombinant Rhesus Macaque CD79B Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Chicken CD79B-1472C Recombinant Chicken CD79B Mammalian Cell His
  • Background
  • Quality Guarantee
  • Case Study
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

What is CD79B protein?

CD79B protein, also known as B-cell antigen receptor complex-associated protein beta chain, is a protein that is involved in B-cell receptor signaling. It is a component of the B-cell receptor (BCR) complex, which plays a crucial role in the activation and function of B cells in the immune system.

CD79B protein is specifically expressed in B cells and is responsible for transducing signals from the BCR to downstream signaling pathways upon antigen recognition. It forms a heterodimer with CD79A protein to form the B-cell antigen receptor complex, which is composed of a membrane-bound immunoglobulin (Ig) molecule and associated CD79A/CD79B heterodimers. This complex is required for the surface expression and signaling of the BCR.

What is the function of CD79B protein?

The main function of CD79B is to transduce signals from the BCR upon antigen recognition. It contains immunoreceptor tyrosine-based activation motifs (ITAMs) in its cytoplasmic tail. Upon binding of antigens to the BCR, CD79B is phosphorylated by the Src family kinases. This phosphorylation leads to the recruitment and activation of downstream signaling molecules, such as Bruton's tyrosine kinase (BTK), which ultimately triggers a cascade of intracellular signaling events necessary for B-cell activation, proliferation, and antibody production.

CD79B related signaling pathway

The CD79B protein is involved in the activation of several signaling pathways, including the BCR signaling pathway, which plays a critical role in B cell development, differentiation, and immune responses. This pathway involves the recruitment and activation of various intracellular signaling molecules, ultimately leading to the activation of transcription factors and gene expression necessary for B cell proliferation, survival, and antibody production.

CD79B Related Diseases

  •  B Cell Lymphomas: CD79B is a key component of the B cell receptor (BCR) complex, which plays a crucial role in B cell activation and survival. Mutations or dysregulation of CD79B can contribute to the development of B cell lymphomas, such as diffuse large B cell lymphoma (DLBCL) and Burkitt lymphoma.
  •  Agammaglobulinemia: CD79B mutations can also lead to a rare genetic disorder known as X-linked agammaglobulinemia (XLA). XLA is characterized by a severe deficiency in B cells, resulting in a lack of antibody production and increased susceptibility to infections.
  •  Autoimmune Diseases: Dysregulation of CD79B signaling has been implicated in the development of autoimmune diseases, such as systemic lupus erythematosus (SLE) and rheumatoid arthritis. Abnormal activation of B cells through the BCR complex, including CD79B, can contribute to the production of autoantibodies and the breakdown of self-tolerance.
  •  B-cell lymphomas: Alterations in CD79B expression or mutations in the CD79B gene have been found in different types of B-cell lymphomas, including diffuse large B-cell lymphoma (DLBCL) and Burkitt lymphoma. These abnormalities can lead to constitutive BCR signaling and contribute to the growth and survival of lymphoma cells.
  •  Autoimmune diseases: CD79B has been implicated in the pathogenesis of autoimmune diseases, such as systemic lupus erythematosus (SLE) and rheumatoid arthritis. Dysregulated BCR signaling mediated by CD79B can result in the production of autoantibodies and immune dysregulation.
  •  B-cell lymphomas: Alterations in CD79B expression or mutations in the CD79B gene have been found in different types of B-cell lymphomas, including diffuse large B-cell lymphoma (DLBCL) and Burkitt lymphoma. These abnormalities can lead to constitutive BCR signaling and contribute to the growth and survival of lymphoma cells.
  •  Autoimmune diseases: CD79B has been implicated in the pathogenesis of autoimmune diseases, such as systemic lupus erythematosus (SLE) and rheumatoid arthritis. Dysregulated BCR signaling mediated by CD79B can result in the production of autoantibodies and immune dysregulation.

High Purity

SDS-PAGE CD79B-0858H.jpg

Fig1. SDS-PAGE (Cat. No.: CD79B-0858H)

High Bioactivity & Detection Sensitivity

CD79B bioactive.jpg

Fig2. CD79B is a 36-40 kDa member of the Ig-Superfamily. It is required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation.

different degrees of CD79b peptide sensitivity.jpg

(Lokenz jahn, 2017)

Fig3. pMHC tetramer CD8+ T cells exhibit different degrees of CD79b peptide sensitivity and specificity. T cells were clonally expanded by single-cell sorting of CD8+ T cells binding to pMHC tetramers containing CD79b peptides. (A) Shown are pMHC-tetramer staining of 5 representative clones (K110, K64, K68, K116, and K308) isolated using pMHC tetramer CD79b173:A2. Control includes clone HSS12 specific for USP11-derived peptide FTWEGLYNV bound to HLA-A2. Shown are CD8+ cells.

DS-PAGE analysis of CD79a-CD79b complex.jpg

(Ben K. Seon, 2024)

Fig4. SDS-PAGE analysis of CD79a/CD79b complex or CD79a and CD79b molecules that are generated by reduction of the disulfide bonds between CD79a and CD79b molecules. Data in Section A are those of SDS-PAGE analysis of the immunoprecipitates from Experiment 1 of Table 1, whereas data in Section B are those of SDS-PAGE analysis of the immunoprecipitates from Experiment 2 of Table 1.

CD79B involved in several pathways and played different roles in them. We selected most pathways CD79B participated on our site, such as B cell receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CD79B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
B cell receptor signaling pathwayCd79a, Cd79b;VAV1;ARPC3;CARD11;RAC2;LCP2A;HRAS;BANK1;SOS1

CD79B has several biochemical functions, for example, protein binding, transmembrane signaling receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CD79B itself. We selected most functions CD79B had, and list some proteins which have the same functions with CD79B. You can find most of the proteins on our site.

Function Related Protein
protein bindingDNAJA1;PTRH2;LCOR;STXBP3;ARAP1;SIK3;STK36;ATP6V1F;ACY3
transmembrane signaling receptor activitySLC22A17;GHRHRL;GHRHRA;TLR18;OR103-4;LGR4;EBP;IL1R1;FZD7A

CD79B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CD79B here. Most of them are supplied by our site. Hope this information will be useful for your research of CD79B.

SGTA; q8ckf8_yerpe

Research Area

Related articles

Lu, D; Jin, JY; et al. POPULATION PHARMACOKINETICS AND EXPOSURE-RESPONSE ASSESSMENT OF ANTI-CD79B ANTIBODY DRUG CONJUGATE IN PATIENTS: INTERIM ANALYSIS RESULTS.. CLINICAL PHARMACOLOGY & THERAPEUTICS 97:S88-S89(2015).
Chang, CH; Wang, Y; et al. Extensive crosslinking of CD22 by epratuzumab triggers BCR signaling and caspase-dependent apoptosis in human lymphoma cells. MABS 7:199-211(2015).
  • Q&As
  • Reviews

Q&As (5)

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How does CD79B-targeted immunotherapy differ from traditional chemotherapy in treating B cell malignancies? 03/27/2021

CD79B-targeted immunotherapy aims to specifically target B cells, potentially reducing side effects compared to non-specific chemotherapy.

How does CD79B contribute to the development of personalized treatment strategies for B cell diseases? 01/12/2021

Analyzing CD79B expression helps tailor treatment plans, allowing for more personalized and effective approaches.

Can CD79B be used as a biomarker for minimal residual disease in B cell malignancies? 05/13/2018

Yes, monitoring CD79B levels can aid in detecting minimal residual disease, providing insights into treatment response.

Are there any challenges or limitations associated with relying on CD79B as a diagnostic marker? 03/02/2017

Variability in CD79B expression among different B cell disorders may pose challenges in its use as a standalone diagnostic marker.

Are there any clinical trials investigating the therapeutic potential of CD79B-targeted drugs? 01/22/2016

Yes, several clinical trials are exploring the efficacy of CD79B-targeted drugs in various B cell disorders.

Customer Reviews (3)

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Reviews
04/26/2023

    Renowned for its reliability and consistency, this protein offers researchers the confidence to achieve accurate and reproducible results in their studies.

    11/16/2021

      The CD79B protein comes highly recommended for its outstanding performance in ELISA assays.

      10/26/2018

        One notable advantage of the CD79B protein is the excellent technical support provided by its manufacturer.

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