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HLA-G

Official Full Name

major histocompatibility complex, class I, G
Overview

HLA-G is a nonclassical MHC class I (MHC-Ib) molecule structurally related to MHC class Ia (HLA-A,B, C). There are seven isoforms of this molecule, including membrane bound HLA-G1, -G2, -G3 and -G4 and soluble HLA-G5, -G6, and -G7. HLA-G is primarily expr
Synonyms

HLA-G; major histocompatibility complex, class I, G; HLA G histocompatibility antigen, class I, G; HLA class I histocompatibility antigen, alpha chain G; b2 microglobulin; HLA G antigen; HLA class I molecule; MHC class I antigen G; HLA-G histocompatibility antigen, class I, G; MHC-G;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Cynomolgus
Human
Rhesus macaque

Source

E. coli
E.coli
HEK293
HEK293T
In Vitro Cell Free System
Mamanlian cells
Mammalian cells
Wheat Germ
Yeast

Tag

Flag
GST
His
Avi
B2M
Fc
SUMO
Myc
DDK
Non

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	HLA-G-501H	Active Recombinant Human HLA-G protein, His-Avi-tagged	HEK293	His&Avi	It contains Gly25-Thr305(HLA-G),Ile21-Met119(B2M) and RIIPRHLQL peptide.	Inquiry
Human	HLA-G-505HP	Active Recombinant Human HLA-G complex Protein (tetramer), His-Avi-tagged, PE-Labeled	HEK293	His&Avi	Gly25-Thr305(HLA-G),Ile21-Met119(B2M) and RIIPRHLQL peptide	Inquiry
Human	HLA-G-4305H	Recombinant Human HLA-G protein, His-B2M-tagged	E.coli	His&B2M	25-308aa	$498 / 20μg
Human	HLA-G-312H	Recombinant Human HLA-G Protein, His-Avi-tagged	HEK293	His&Avi	It contains Gly25-Thr305 (HLA-G), Ile21-Met119 (B2M) and RIIPRHLQL peptide.	$319 / 25μg
Human	HLA-G-26H	Recombinant Human HLA-G protein, MYC/DDK-tagged	HEK293	Myc&DDK		Inquiry
Human	HLA-G-1241H	Recombinant Human HLA-G Protein, His-tagged	HEK293	His		$1,380 / 100μg
Human	HLA-G-13828H	Recombinant Human HLA-G, GST-tagged	E.coli	GST	26-308a.a.	$319 / 25μg
Human	HLA-G-27H	Recombinant Human HLA-G protein, GST-tagged	Wheat Germ	GST		$398 / 2μg $998 / 10μg
Human	HLA-G-38H	Recombinant Human HLA-G protein, His-tagged	E.coli	His		Inquiry
Human	HLA-G-5493HCL	Recombinant Human HLA 293 Cell Lysate	HEK293	Non		Inquiry
Human	HLA-G-033H	Recombinant Human HLA-G Protein, His-tagged	E.coli	His	26-308 aa	$319 / 25μg
Human	HLA-G-39H	Recombinant Human HLA-G protein, His/SUMO-tagged	E.coli	His&SUMO	314	$786 / 50µg
Human	HLA-G-2243H	Recombinant Human HLA-G Protein, His-tagged	E.coli	His	Gly25-Ile308	Inquiry
Human	HLA-G-3036H	Recombinant Human HLA-G protein, His-SUMO-tagged	E.coli	His&SUMO	25-308aa	Inquiry
Human	HLA-G-2792HFL	Recombinant Full Length Human HLA-G protein, Flag-tagged	Mamanlian cells	Flag		Inquiry
Human	HLA-G-001H	Active Recombinant Human HLA-G Protein, Myc/DDK-tagged	HEK293T	Myc&DDK		$699 / 20μg $3,398 / 100μg
Human	HLA-G-5426H	Recombinant Human HLA-G protein, His-sumostar-tagged	Yeast	His&SUMO	25-338aa	Inquiry
Human	HLA-G-502H	Recombinant Human HLA-G protein(Gly25-Thr305(C66S)), His-Avi-tagged	E. coli	His&Avi	Gly25-Thr305(C66S)	Inquiry
Human	HLA-G-1077H	Recombinant Human HLA-G Protein, His (Fc)-Avi-tagged	HEK293	His&Fc&Avi		Inquiry
Human	HLA-G-1718HFL	Recombinant Full Length Human HLA-G Protein, C-Flag-tagged	Mammalian cells	Flag		Inquiry
Human	HLA-G-651HF	Recombinant Full Length Human HLA-G Protein, GST-tagged	In Vitro Cell Free System	GST	338 amino acids	Inquiry
Human	HLA-G-503H	Recombinant Human HLA-G protein, His-Avi-tagged, Biotinylated	HEK293	His&Avi	It contains Gly25-Thr305(HLA-G),Ile21-Met119(B2M) and RIIPRHLQL peptide.	Inquiry
Human	HLA-G-3075H	Recombinant Human HLA-G Protein (Met29-His117), N-GST tagged	E.coli	GST	Met29-His117	Inquiry
Human	HLA-G-1077H-B	Recombinant Human HLA-G Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Human	HLA-G-504H	Recombinant Human HLA-G protein, His-Avi-tagged, Biotinylated	HEK293	His&Avi	It contains Gly25-Thr305(HLA-G),Ile21-Met119(B2M) and RIIPRHLQL peptide.	Inquiry
Cynomolgus	HLA-G-505C	Recombinant Cynomolgus HLA-G Tetramer protein, His-Avi-tagged	HEK293	His&Avi	Gly25-Thr305(HLA-G)&Ile21-Met119(B2M)	Inquiry
Cynomolgus	HLA-G-503C	Recombinant Cynomolgus HLA-G protein, His-Avi-tagged	HEK293	His&Avi	Gly25-Thr305(HLA-G),Ile21-Met119(B2M) and RIIPRHLQL peptide	Inquiry
Cynomolgus	HLA-G-503CB	Recombinant Cynomolgus HLA-G protein, His-Avi-tagged, Biotinylated	HEK293	His&Avi	Gly25-Thr305(HLA-G),Ile21-Met119(B2M) and RIIPRHLQL peptide	Inquiry
Rhesus macaque	HLA-G-506R	Recombinant Rhesus macaque HLA-G protein, His-Avi-tagged	HEK293	His&Avi	It contains Gly25-Thr305(HLA-G),Ile21-Met119(B2M) and RIIPRHLQL peptide.	Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource

HLA-G involved in several pathways and played different roles in them. We selected most pathways HLA-G participated on our site, such as Endocytosis, Phagosome, Cell adhesion molecules (CAMs), which may be useful for your reference. Also, other proteins which involved in the same pathway with HLA-G were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Endocytosis	TGFB3;TGFBR1A;SH3GL3B;WASLA;HLA-G;CXCR4;EPS15;KIF5B;ERBB3B
Phagosome	NOS1;DYNC1I2A;FAM49BA;ITGB3B;ATP6AP1B;ITGB2;ATP6V1A;MRC1;HLA-DRA
Cell adhesion molecules (CAMs)	ITGA8;CLDNK;ICAM1;CD99;CLDN11B;SELP;F11R;NRXN2A;NCAM1A
Antigen processing and presentation	NFYC;HLA-DQA2;HLA-DRB4;TNF;TAP1;HLA-DRA;HLA-DRB3;HLA-DPA1;PSME2
Natural killer cell mediated cytotoxicity	TNFRSF10C;SH2D1B;IFNA10;RAC1;GZMB;TNF;SYK;TNFRSF10A;PRKCG
Type I diabetes mellitus	HLA-DOB;Fasl;HLA-DPA1;IL12B;HLA-F;CD86;HLA-C;GAD1;HLA-DRB3
HTLV-I infection	TNFRSF1A;ITGB2;FOSL1;PIK3CG;Pdgfa&Pdgfb;TRP53INP1;CDC26;SLC25A31;CD3D
Herpes simplex infection	SRSF2A;EEF1DA;FADD;MAPK9;HLA-DMB;HLA-DOA;NFKBIA;IFNPHI3;NXF3
Epstein-Barr virus infection	FGR;DDX58;EIF2AK1;RBPJ;AKT1;TRP53;CD19;HLA-DRB1;CD38
Viral carcinogenesis	HIST1H2BK;RBPJL;CREB3L2;RB1;HLA-F;UBR4;HIST1H4A;HIST1H2BL;PIK3CD
Autoi	IFNA14;HLA-F;Fasl;IL4;IFNA1;HLA-DPB1;CD80;GZMB;HLA-DRB4
ne thyroid disease	HLA-DMB;HLA-DQA2;HLA-DPA1;HLA-DRB3;PRF1;TSHR;IFNA13;HLA-DRA;TSHB
Allograft rejection	GZMB;H2-Q10;HLA-B;IL12A;HLA-DPB1;HLA-DQB1;CD86;PRF1;IL4
Graft-versus-host disease	HLA-DMA;KIR2DL3;HLA-DOA;HLA-F;IFNG;PRF1;FASLG;Fasl;GZMB
Viral myocarditis	ICAM1;EIF4G3;RAC2;HLA-G;ACTB;HLA-DQA1;HLA-DRB4;CD86;PRF1

HLA-G has several biochemical functions, for example, peptide antigen binding, protein homodimerization activity, receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HLA-G itself. We selected most functions HLA-G had, and list some proteins which have the same functions with HLA-G. You can find most of the proteins on our site.

Function	Related Protein
peptide antigen binding	MHC1ZKA;MHC1UIA;AZGP1;TAP1;TRGV3;MHC1UJA;HLA-E;DHCR24;HLA-DRB5
protein homodimerization activity	ACOT7;BCL2;STK25;TERF2;PLD6;ACTN4;GDNF;NOS1;LRP4
receptor binding	GUSB;TNFSF4;PVRL3B;MTSS1;CCL13;APOL2;ARRB2;Itga10&Itgb1;IFNL3

HLA-G has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HLA-G here. Most of them are supplied by our site. Hope this information will be useful for your research of HLA-G.

LILRB1; HLA-A

Research Area

T Cell Antigen Recognition

Brugiere, O; Thabut, G; et al. Role of HLA-G as a Predictive Marker of Low Risk of Chronic Rejection in Lung Transplant Recipients: A Clinical Prospective Study. AMERICAN JOURNAL OF TRANSPLANTATION 15:461-471(2015).

Han, MY; Jiang, YZ; et al. sHLA-G Involved in the Apoptosis of Decidual Natural Killer Cells Following Toxoplasma gondii Infection. INFLAMMATION 37:1718-1727(2014).