HLA-G Protein


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Official Full Name major histocompatibility complex, class I, G
Background HLA-G is a nonclassical MHC class I (MHC-Ib) molecule structurally related to MHC class Ia (HLA-A,B, C). There are seven isoforms of this molecule, including membrane bound HLA-G1, -G2, -G3 and -G4 and soluble HLA-G5, -G6, and -G7. HLA-G is primarily expr
Synonyms HLA-G; major histocompatibility complex, class I, G; HLA G histocompatibility antigen, class I, G; HLA class I histocompatibility antigen, alpha chain G; b2 microglobulin; HLA G antigen; HLA class I molecule; MHC class I antigen G; HLA-G histocompatibility antigen, class I, G; MHC-G
    • Species :
    • Cynomolgus
    • Human
    • Rhesus macaque
    • Source :
    • E. coli
    • E.coli
    • HEK293
    • HEK293T
    • Wheat Germ
    • Tag :
    • GST
    • His
    • SUMO
    • His-Avi
    • His-B2M
    • His-SUMO
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human HLA-G-26H Recombinant Human HLA-G protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human HLA-G-27H Recombinant Human HLA-G protein, GST-tagged Wheat Germ GST
    Human HLA-G-3036H Recombinant Human HLA-G protein, His-SUMO-tagged E.coli His-SUMO
    Human HLA-G-4305H Recombinant Human HLA-G protein, His-B2M-tagged E.coli His-B2M
    Human HLA-G-501H Recombinant Human HLA-G protein, His-Avi-tagged HEK293 His-Avi
    Human HLA-G-502H Recombinant Human HLA-G(C66S) protein, His-Avi-tagged HEK293 His-Avi
    Human HLA-G-503H Recombinant Human HLA-G protein, His-Avi-tagged, Biotinylated HEK293 His-Avi
    Human HLA-G-504H Recombinant Human HLA-G protein, His-Avi-tagged, Biotinylated HEK293 His-Avi
    Cynomolgus HLA-G-505C Recombinant Cynomolgus HLA-G protein, His-Avi-tagged HEK293 His-Avi
    Rhesus macaque HLA-G-506R Recombinant Rhesus macaque HLA-G protein, His-Avi-tagged HEK293 His-Avi
    Human HLA-G-001H Recombinant Human HLA-G Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Human HLA-G-033H Recombinant Human HLA-G Protein, His-tagged E. coli His
    Human HLA-G-1241H Recombinant Human HLA-G Protein, His-tagged HEK293 His
    Human HLA-G-13828H Recombinant Human HLA-G, GST-tagged E.coli GST
    Human HLA-G-312H Recombinant Human HLA-G Protein, His-Avi-tagged HEK293 His-Avi
    Human HLA-G-38H Recombinant Human HLA-G protein, His-tagged E.coli His
    Human HLA-G-39H Recombinant Human HLA-G protein, His/SUMO-tagged E.coli His/SUMO
    Human HLA-G-5493HCL Recombinant Human HLA 293 Cell Lysate HEK293 N/A

    HLA-G involved in several pathways and played different roles in them. We selected most pathways HLA-G participated on our site, such as Endocytosis, Phagosome, Cell adhesion molecules (CAMs), which may be useful for your reference. Also, other proteins which involved in the same pathway with HLA-G were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Endocytosis BIN1; ARRB2; SNX12; PRKCI; NTRK1; EHD1; SNX1; SNX2; PIP5K1C; STAM2
    Phagosome FCGR1A; SEC61G; ATP6V0A1; BLB2; TUBA4L; BMA1; HLA-DRB5; TUBA1L2; HLA-DOA; ITGB1B.2
    Cell adhesion molecules (CAMs) CLDN5; HLA-DRB5; OCLN; MADCAM1; BMA1; ITGAL; VTCN1; ITGAV; NEGR1; CNTNAP2
    Antigen processing and presentation H2-Q10; KLRC4; KIR2DL1; KLRC3; PSME1; HLA-B; KLRC1; KIR3DL2; H2-AA; KLRC2
    Natural killer cell mediated cytotoxicity ZAP70; PLCG2; SH3BP2; IFNA6; FCGR4; MAPK3; PRKCA; HLA-G; PIK3R5; KLRA8
    Type I diabetes mellitus HLA-DRA; HLA-DRB4; LTA; HLA-DQA1; HLA-DMB; HSPD1; HLA-DQA2; IL1B; HLA-DRB5; ICA1
    HTLV-I infection TNF; CD40; CANX; IL15RA; PIK3R5; CD3D; WNT7B; PIK3R3; RB1; ATM
    Herpes simplex infection MHC2DEB; HCFC1B; TAP2; SRSF1A; IL12A; MHC2A; HLA-DRB5; BLB2; RNASEL; HCFC1
    Epstein-Barr virus infection HDAC5; PRKACB; TRAF3; RBPJ; TYK2; PLCG1; YWHAH; PSMC4; PIK3R1; IRF3
    Viral carcinogenesis UBE3A; HIST1H4H; HIST1H2BA; IRF7; HIST1H4D; TBP; TRADD; RBL2; SCRIB; HIST1H4N
    Autoi IFNA14; HLA-DRB5; TPO; TG; IFNA4; Ifna11; Ifna15; HLA-DRB3; Fasl; CD40
    ne thyroid disease IFNA5; GZMB; HLA-DQB1; TSHB; HLA-DRB5; IFNA4; PRF1; FAS; CD86; CD40
    Allograft rejection HLA-DRA; Fasl; IL4; HLA-DQA1; CD28; H2-AB1; HLA-DRB1; H2-AA; HLA-DPB1; MICA
    Graft-versus-host disease FASLG; HLA-DOA; KIR3DL1; KLRD1; KIR2DL3; IFNG; HLA-A; Fasl; KIR2DL1; HLA-F
    Viral myocarditis CD28; H2-AA; Casp3; CD80; EIF4G3; BID; EIF4G2; CASP8; ITGB2; HLA-C

    HLA-G has several biochemical functions, for example, peptide antigen binding, protein homodimerization activity, receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HLA-G itself. We selected most functions HLA-G had, and list some proteins which have the same functions with HLA-G. You can find most of the proteins on our site.

    Function Related Protein
    peptide antigen binding HLA-DQA1; HLA-DPB1; MHC1UEA; TAPBP; HLA-DRB1; HLA-B; TAP1; MR1; HLA-A; AZGP1
    protein homodimerization activity CISD2; ADD1; DARS2; TFRC; CTBP1; HNF1A; FAM109A; FLT3; GIMAP7; GRPEL1
    receptor binding CD72; LRP6; SSTR3; PVRL3B; CD276; RIPK2; HIST2H3C2; PTK6; LGI1; WIPI1

    HLA-G has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HLA-G here. Most of them are supplied by our site. Hope this information will be useful for your research of HLA-G.


    Brugiere, O; Thabut, G; et al. Role of HLA-G as a Predictive Marker of Low Risk of Chronic Rejection in Lung Transplant Recipients: A Clinical Prospective Study. AMERICAN JOURNAL OF TRANSPLANTATION 15:461-471(2015).
    Han, MY; Jiang, YZ; et al. sHLA-G Involved in the Apoptosis of Decidual Natural Killer Cells Following Toxoplasma gondii Infection. INFLAMMATION 37:1718-1727(2014).

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