HLA-G

  • Official Full Name

    major histocompatibility complex, class I, G

  • Overview

    HLA-G is a nonclassical MHC class I (MHC-Ib) molecule structurally related to MHC class Ia (HLA-A,B, C). There are seven isoforms of this molecule, including membrane bound HLA-G1, -G2, -G3 and -G4 and soluble HLA-G5, -G6, and -G7. HLA-G is primarily expr

  • Synonyms

    HLA-G;major histocompatibility complex, class I, G;HLA G histocompatibility antigen, class I, G;HLA class I histocompatibility antigen, alpha chain G;b2 microglobulin;HLA G antigen;HLA class I molecule;MHC class I antigen G;HLA-G histocompatibility antigen, class I, G;MHC-G

Recombinant Proteins

  • Human
  • Cynomolgus
  • Rhesus macaque
  • HEK293
  • E.coli
  • Wheat Germ
  • Mammalian Cells
  • Insect cells
  • Yeast
  • In Vitro Cell Free System
  • Avi
  • His
  • B2M
  • GST
  • DDK
  • Myc
  • SUMO
  • Non
  • Fc
  • Flag
Cat.# Product name Source (Host) Species Tag Protein Length Price
HLA-G-312H Recombinant Human HLA-G Protein, His-Avi-tagged HEK293 Human Avi&His It contains Gly25-Thr305 (HLA-G), Ile21-Met119 (B2M) and RIIPRHLQL peptide.
HLA-G-4305H Recombinant Human HLA-G protein, His-B2M-tagged E.coli Human B2M&His 25-308aa
HLA-G-1241H Recombinant Human HLA-G Protein HEK293 Human His 25-338 a.a.
HLA-G-13828H Recombinant Human HLA-G, GST-tagged E.coli Human GST 26-308a.a.
HLA-G-27H Recombinant Human HLA-G protein, GST-tagged Wheat Germ Human GST 1-338 a.a.
HLA-G-001H Active Recombinant Human HLA-G Protein, Myc/DDK-tagged HEK293 Human DDK&Myc
HLA-G-033H Recombinant Human HLA-G Protein, His-tagged E.coli Human His 26-308 aa
HLA-G-39H Recombinant Human HLA-G protein E.coli Human His&SUMO 25-338 a.a.
HLA-G-501H Active Recombinant Human HLA-G protein, His-Avi-tagged HEK293 Human Avi&His It contains Gly25-Thr305(HLA-G),Ile21-Met119(B2M) and RIIPRHLQL peptide.
HLA-G-505HP Active Recombinant Human HLA-G complex Protein (tetramer), His-Avi-tagged, PE-Labeled HEK293 Human Avi&His Gly25-Thr305(HLA-G),Ile21-Met119(B2M) and RIIPRHLQL peptide
HLA-G-26H Recombinant Human HLA-G protein, MYC/DDK-tagged HEK293 Human DDK&Myc
HLA-G-38H Recombinant Human HLA-G protein E.coli Human His 25-338 a.a.
HLA-G-5493HCL Recombinant Human HLA 293 Cell Lysate HEK293 Human Non
HLA-G-1077H Recombinant Human HLA-G Protein, His (Fc)-Avi-tagged HEK293 Human Avi&Fc&His
HLA-G-1077H-B Recombinant Human HLA-G Protein Pre-coupled Magnetic Beads HEK293 Human
HLA-G-1242H Recombinant Human HLA-G & B2M Protein, His-tagged HEK293 Human His
HLA-G-1718HFL Recombinant Full Length Human HLA-G Protein, C-Flag-tagged Mammalian Cells Human Flag Full L.
HLA-G-2243H Recombinant Human HLA-G Protein, His-tagged E.coli Human His Gly25-Ile308
HLA-G-3036H Recombinant Human HLA-G protein, His-SUMO-tagged E.coli Human His&SUMO 25-308aa
HLA-G-3075H Recombinant Human HLA-G Protein (Met29-His117), N-GST tagged E.coli Human GST Met29-His117
HLA-G-3322H Recombinant Human HLA-G protein, His-tagged Insect cells Human His 25-319aa
HLA-G-502H Recombinant Human HLA-G protein(Gly25-Thr305(C66S)), His-Avi-tagged E.coli Human Avi&His Gly25-Thr305(C66S)
HLA-G-503C Recombinant Cynomolgus HLA-G protein, His-Avi-tagged HEK293 Cynomolgus Avi&His Gly25-Thr305(HLA-G),Ile21-Met119(B2M) and RIIPRHLQL peptide
HLA-G-503CB Recombinant Cynomolgus HLA-G protein, His-Avi-tagged, Biotinylated HEK293 Cynomolgus Avi&His Gly25-Thr305(HLA-G),Ile21-Met119(B2M) and RIIPRHLQL peptide
HLA-G-503H Recombinant Human HLA-G protein, His-Avi-tagged, Biotinylated HEK293 Human Avi&His It contains Gly25-Thr305(HLA-G),Ile21-Met119(B2M) and RIIPRHLQL peptide.
HLA-G-504H Recombinant Human HLA-G protein, His-Avi-tagged, Biotinylated HEK293 Human Avi&His It contains Gly25-Thr305(HLA-G),Ile21-Met119(B2M) and RIIPRHLQL peptide.
HLA-G-505C Recombinant Cynomolgus HLA-G Tetramer protein, His-Avi-tagged HEK293 Cynomolgus Avi&His Gly25-Thr305(HLA-G)&Ile21-Met119(B2M)
HLA-G-506R Recombinant Rhesus macaque HLA-G protein, His-Avi-tagged HEK293 Rhesus macaque Avi&His It contains Gly25-Thr305(HLA-G),Ile21-Met119(B2M) and RIIPRHLQL peptide.
HLA-G-5426H Recombinant Human HLA-G protein Yeast Human His&SUMO 25-338 a.a.
HLA-G-651HF Recombinant Full Length Human HLA-G Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 338 amino acids

    Involved Pathway

    HLA-G involved in several pathways and played different roles in them. We selected most pathways HLA-G participated on our site, such as Endocytosis,Phagosome,Cell adhesion molecules (CAMs), which may be useful for your reference. Also, other proteins which involved in the same pathway with HLA-G were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Endocytosis PSD4,VPS24,ASAP3,RNF41,RAB7,ZFP652,CYTH4B,FOLR1,HSPA6,DAB2
    ne thyroid disease TSHR,IFNA12,HLA-DMA,IFNA1,HLA-DRB4,IFNA8,IFNA16,HLA-DMB,HLA-F,HLA-DOA
    Herpes simplex infection HLA-E,PVRL1,USP7,TRAF6,PTPN11B,UBE2R2,SRSF1A,HMGN1,EIF2AK3,HLA-F
    Viral carcinogenesis HDAC9,PKM2,SKP2,HDAC3,GTF2H2C_2,STAT5B,HIST1H4N,CASP8,HIST1H4D,STAT5A
    Viral myocarditis ACTB,CASP9,RAC3,Casp3,CD80,CCND1,CD28,ABL2,RAC1,CD86
    Phagosome TUBA4A,HLA-DOB,CTSSB.1,ATP6V0E,THBS4,C1R,FAM49BA,DYNC1LI2,STX18,BLB2
    Allograft rejection HLA-A,MICA,HLA-DRB3,HLA-DQB1,Il2,CD86,H2-AA,Fasl,FASLG,HLA-DMA
    Natural killer cell mediated cytotoxicity PAK1,PIK3CA,Ifna15,KIR2DL4,PLCG2,IFNA8,TNFRSF10D,IFNA6,RAET1L,PRKCG
    Cell adhesion molecules (CAMs) CLDN16,CLDN15LA,CLDN5B,MPZL1,ITGA6,CD6,PVRL1,CD276,MHC2A,NRXN1A

    Protein Function

    HLA-G has several biochemical functions, for example, peptide antigen binding,protein homodimerization activity,receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HLA-G itself. We selected most functions HLA-G had, and list some proteins which have the same functions with HLA-G. You can find most of the proteins on our site.

    Function Related Protein
    receptor binding HTT,CAPRIN2,FGF11,ADCYAP1,TNFSF12,FIS1,HLA-F,PTK6B,WNT2BB,WNT2BA
    peptide antigen binding MHC1ZFA,MHC1UKA,HLA-DQB1,HLA-DQA1,MHC1ZHA,MHC1UXA2,TRGV3,HLA-A,H2-AA,HLA-DPB1
    protein homodimerization activity HOMER2,CUL3,PTPRE,GRPEL2,MASP1,FLNA,ADRA2A,DAXX,FIGF,S100A5

    Interacting Protein

    HLA-G has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HLA-G here. Most of them are supplied by our site. Hope this information will be useful for your research of HLA-G.

    LILRB1;HLA-A

    Resources

    Partnership Opportunity for High-Quality Recombinant HLA-G Proteins from Creative BioMart

    Partnership Opportunity for High-Quality Recombinant HLA-G Proteins from Creative BioMart

    Gene Families

    Research Area

    References

    • Han, MY; Jiang, YZ; et al. sHLA-G Involved in the Apoptosis of Decidual Natural Killer Cells Following Toxoplasma gondii Infection. INFLAMMATION 37:1718-1727(2014).
    • Brugiere, O; Thabut, G; et al. Role of HLA-G as a Predictive Marker of Low Risk of Chronic Rejection in Lung Transplant Recipients: A Clinical Prospective Study. AMERICAN JOURNAL OF TRANSPLANTATION 15:461-471(2015).

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