Fc Receptors
Related Symbol Search List
- FCAMR
- CD89
- FCER1A
- FCER1G
- FCER2
- CD64
- CD32A
- Fcgr2b
- CD16
- FCGR3
- CD16a
- FCGR3B
- FCGR4
- FCGRT
- FCGRT
- FCRL1
- FCRL3
- FCRL4
- MS4A2
Immunology Background
Comprehensive Fc Receptor Products for Antibody Research and Immune Function Studies
Creative BioMart provides a broad range of Fc receptor-related recombinant proteins and customized protein solutions to support immunology research, antibody drug discovery, Fc engineering, binding analysis, and functional evaluation. Our Fc receptor portfolio covers key FcR families including Fcγ receptors, Fcε receptors, Fcα receptors, Fcμ receptors, neonatal Fc receptor FcRn, and Fc receptor-like proteins.
Whether you are studying antibody-dependent cellular cytotoxicity, phagocytosis, immune complex clearance, allergic inflammation, IgG recycling, or antibody therapeutic development, Creative BioMart offers flexible product formats and technical support to help accelerate your research.
What Are Fc Receptors?
Fc receptors, also known as FcRs, are cell-surface receptors that recognize and bind the Fc region of antibodies. Through this interaction, immune cells can identify antibody-coated pathogens, tumor cells, allergens, or immune complexes and initiate downstream immune responses.
Fc receptors are widely involved in antibody-mediated effector functions, including antibody-dependent cellular cytotoxicity, antibody-dependent cellular phagocytosis, immune complex clearance, inflammatory mediator release, and regulation of immune activation or inhibition. Different antibody classes, such as IgG, IgE, IgA, and IgM, interact with distinct Fc receptor families, creating diverse immune outcomes in infection, allergy, autoimmunity, inflammation, cancer immunology, and therapeutic antibody development. Creative BioMart's current Fc receptor research page also highlights ADCC, phagocytosis, inflammatory mediator release, immune complex clearance, FcRn-mediated IgG transport, and immune regulation as core FcR functions.
Major Fc Receptor Families Covered
Fcγ Receptors
Fcγ receptors bind the Fc region of IgG antibodies and are among the most widely studied Fc receptor families in antibody drug research. They are expressed on immune cells such as NK cells, macrophages, neutrophils, dendritic cells, and other effector cells.
Key research areas include:
- ADCC mediated by FcγRIII/CD16 or CD16a
- ADCP and immune complex uptake mediated by FcγRI/CD64 and FcγRII/CD32
- Activating versus inhibitory Fcγ receptor signaling
- FcγRIIb-mediated immune suppression
- Fc engineering and antibody effector function optimization
- Fcγ receptor binding comparison across species or variants
Representative targets may include CD64/FCGR1, CD32/FCGR2A, FCGR2B, CD16/FCGR3A, FCGR3B, and mouse or cynomolgus Fcγ receptor homologs.
Fig.1 Schematic 3-dimensional structure of Fc γ RIII. (Takai T, 2005)
Fcε Receptors
Fcε receptors recognize IgE and are closely associated with allergic inflammation, asthma, mast cell activation, basophil biology, and hypersensitivity responses. FcεRI is a high-affinity IgE receptor, while FcεRII/CD23 plays important roles in IgE regulation and B-cell-related immune responses.
Representative targets may include FCER1A, FCER1G, FCER2/CD23, and MS4A2.
Fcα Receptors
Fcα receptors bind IgA antibodies and are important in mucosal immunity, phagocyte activation, immune complex clearance, and host defense. CD89/FCAR is commonly studied in IgA-mediated immune responses and inflammatory disease models.
Representative targets may include CD89/FCAR and FCAMR.
Fcμ Receptors and Fcα/μ Receptors
Fcμ receptors are involved in IgM-related immune recognition and B cell regulation. Fcα/μ receptor family members can contribute to the recognition of IgM or IgA immune complexes and are relevant to humoral immunity and immune regulation studies.
Representative targets may include FCMR and FCAMR.
FcRn
The neonatal Fc receptor, FcRn, is a key regulator of IgG transport, IgG recycling, and serum half-life. FcRn is highly relevant to antibody pharmacokinetics, Fc engineering, therapeutic antibody half-life extension, and maternal-fetal IgG transfer research.
Representative products may include FCGRT alone or FCGRT complexed with B2M.
Fc Receptor-Like Proteins
Fc receptor-like proteins, or FCRLs, share structural similarity with Fc receptors and are studied in B cell biology, immune regulation, hematologic malignancies, autoimmune diseases, and biomarker research.
Representative targets may include FCRL1, FCRL3, FCRL4, and related FCRL family members.
Creative BioMart Fc Receptor Product Categories
Creative BioMart offers Fc receptor-related products in multiple formats to support different experimental workflows. Existing Creative BioMart Fc receptor listings include recombinant proteins expressed in systems such as HEK293, human cells, and E. coli, with tags and formats such as His, GST, Fc, His-Avi, and biotinylated proteins.
Recombinant Fc Receptor Proteins
High-quality recombinant Fc receptor proteins are suitable for binding assays, immunogen preparation, screening workflows, antibody characterization, and functional studies.
Common options include:
- Human Fc receptor proteins
- Mouse Fc receptor proteins
- Rat Fc receptor proteins
- Cynomolgus Fc receptor proteins
- Other species-specific FcR proteins upon request
- Extracellular domains and soluble receptor formats
- Fc receptor proteins with His, Fc, GST, Avi, or other tags
Biotinylated Fc Receptor Proteins
Biotinylated Fc receptor proteins are useful for SPR, BLI, ELISA, flow-based binding assays, receptor-ligand interaction studies, and high-throughput antibody screening.
Potential applications include:
- Fc–FcR binding measurement
- Antibody candidate ranking
- Fc engineering evaluation
- Fc receptor selectivity profiling
- Lot-to-lot comparability studies
Active Fc Receptor Proteins
Activity-verified Fc receptor proteins can support assays where confirmed binding or functional performance is important, such as antibody potency evaluation, ligand-binding studies, and biologics development workflows.
Fluorescent-Labeled Fc Receptor Proteins
Fluorescent-labeled Fc receptor proteins may be used in flow cytometry, receptor binding visualization, cell-based assays, and direct detection workflows.
Custom Fc Receptor Protein Services
For targets, formats, tags, species, domains, or modifications not available as catalog products, Creative BioMart provides customized protein expression and purification services. Options may include custom construct design, expression system selection, tag design, protein purification, biotinylation, labeling, endotoxin control, and analytical characterization.
Fig.2 Major functions of FcRs. (Takai T, 2005)
Antibody Drug Discovery
Fc receptor products are widely used to evaluate Fc-mediated immune functions during monoclonal antibody, bispecific antibody, multispecific antibody, ADC, and Fc-fusion protein development.
Key uses include:
- Fc receptor binding screening
- Antibody Fc region optimization
- Species cross-reactivity assessment
- Candidate ranking during early discovery
- FcγRIIIa/CD16a binding analysis for ADCC-related studies
- FcγRIIb binding studies for inhibitory signaling and immune modulation
ADCC, ADCP, and Immune Effector Function Research
Fcγ receptors mediate critical antibody effector functions such as ADCC and phagocytosis. Creative BioMart Fc receptor proteins can be used to study how antibody Fc regions interact with immune effector cells and how Fc engineering may alter immune activation.
FcRn and Antibody Half-Life Studies
FcRn regulates IgG recycling and contributes to antibody serum persistence. FcRn-related proteins are useful for studying pH-dependent IgG binding, Fc engineering, half-life extension strategies, and pharmacokinetic behavior of antibody therapeutics.
Allergy and IgE-Mediated Immune Research
Fcε receptor products support research on IgE binding, mast cell and basophil activation, allergic inflammation, asthma, and hypersensitivity mechanisms.
Mucosal Immunity and IgA Research
Fcα receptor-related products help researchers investigate IgA-mediated immune defense, immune complex clearance, phagocyte activation, mucosal immunity, and inflammatory responses.
Autoimmunity and Inflammation
Dysregulated Fc receptor signaling is associated with immune imbalance, autoimmune disease, chronic inflammation, immune complex deposition, and tissue damage. Fc receptor proteins can support mechanistic studies and therapeutic strategy development.
CMC, Comparability, and Functional Characterization
Fc receptor binding assays are increasingly used in biologics development to support activity assessment, comparability studies, batch-to-batch consistency evaluation, and biosimilar characterization. Competitor pages also emphasize Fc receptor proteins for antibody screening, CMC activity detection, consistency evaluation, and safety verification.
Featured Fc Receptor Targets
Creative BioMart supports a wide range of Fc receptor-related targets, including but not limited to:
- FCGR1 / CD64
- FCGR2A / CD32A
- FCGR2B / CD32B
- FCGR3A / CD16a
- FCGR3B / CD16b
- FCGR4
- FCGRT / FcRn
- B2M-associated FcRn complex
- FCER1A
- FCER1G
- FCER2 / CD23
- FCAR / CD89
- FCAMR
- FCRL1
- FCRL3
- FCRL4
- MS4A2
Our Featured Products
Why Choose Creative BioMart?
Creative BioMart provides researchers with Fc receptor products and custom protein solutions designed for flexibility, application relevance, and experimental compatibility.
- Broad Fc Receptor Coverage
Our Fc receptor portfolio spans major FcR families, including FcγR, FcεR, FcαR, FcμR, FcRn, and Fc receptor-like proteins.
- Multiple Species and Formats
We offer Fc receptor proteins from commonly used research species, with various tags, expression systems, biotinylated formats, active proteins, and custom configurations.
- Support for Antibody Research Workflows
Our products support Fc–Fc receptor binding analysis, antibody screening, Fc engineering, ADCC/ADCP-related research, FcRn studies, allergy research, inflammation studies, and immune regulation research.
- Custom Protein Capabilities
For specialized projects, Creative BioMart can provide customized Fc receptor protein expression, purification, labeling, biotinylation, and analytical services to match your experimental needs.
- Integrated Research Resources
Beyond products, Creative BioMart provides Fc receptor-related information on pathways, protein functions, interacting proteins, research areas, articles, and other resources to help researchers better understand Fc receptor biology.
Suggested Product Navigation Blocks
By Fc Receptor Family
- Fcγ Receptor Proteins
- Fcε Receptor Proteins
- Fcα Receptor Proteins
- Fcμ Receptor Proteins
- FcRn Proteins
- Fc Receptor-Like Proteins
By Application
- Fc–FcR Binding Assay Proteins
- ADCC Research Proteins
- ADCP Research Proteins
- FcRn Half-Life Research Proteins
- Allergy and IgE Research Proteins
- IgA and Mucosal Immunity Research Proteins
- Antibody Drug Development Proteins
- CMC and Comparability Assay Reagents
By Format
- Recombinant Fc Receptor Proteins
- Biotinylated Fc Receptor Proteins
- Active Fc Receptor Proteins
- Fluorescent-Labeled Fc Receptor Proteins
- Custom Fc Receptor Proteins
FAQ
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What are Fc receptor proteins used for?
Fc receptor proteins are used to study interactions between antibodies and immune receptors. They are commonly applied in antibody drug screening, Fc engineering, ADCC/ADCP research, FcRn-mediated IgG recycling studies, allergy research, immune complex clearance studies, and biologics characterization.
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Which Fc receptor is most relevant to ADCC?
FcγRIIIa, also known as CD16a, is one of the most important Fc receptors for ADCC studies because it is expressed on NK cells and binds IgG Fc regions involved in antibody-mediated cytotoxic activity.
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Which Fc receptor is important for antibody half-life?
FcRn, encoded by FCGRT and associated with B2M, plays a major role in IgG recycling and serum half-life regulation. It is widely studied in therapeutic antibody pharmacokinetics and Fc engineering.
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Can Creative BioMart provide custom Fc receptor proteins?
Yes. Creative BioMart provides customized protein services to meet specific project requirements, including target selection, construct design, expression, purification, tagging, biotinylation, labeling, and analytical support.
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How should I choose an Fc receptor product?
Selection depends on the antibody class, assay format, target species, desired receptor family, tag, expression system, and downstream application. For example, FcγRIIIa/CD16a is commonly selected for ADCC-related studies, FcRn for IgG half-life research, FcεRI or FcεRII for IgE/allergy studies, and CD89/FCAR for IgA-related immune research.
Advance Your Fc Receptor Research with Creative BioMart
Creative BioMart offers Fc receptor recombinant proteins, assay-ready reagents, and custom protein solutions to support immunology, antibody engineering, biologics development, and translational research. Contact us to discuss your target, species, tag, expression system, assay format, or custom Fc receptor protein requirements.
Resource
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What Are Fc Receptors? The Immune System's Antibody Response Switch
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FcRn: The Secret to Long-Lasting Antibodies!
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ADCC vs ADCP: How Fcγ Receptors Drive Cancer Immunity
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CD64: The Tiny Receptor with Big Implications!
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Fc Receptor Polymorphisms: Why Antibody Responses Differ Between Patients